Genetics of anti-cytokine autoantibodies suggest they protect against cancer or drive metabolic disease. Pairing GWAS with seromic profiling captures the environmental triggers driving autoimmunity for critical multi-omic insights. rdcu.be/b4nyEn1C5Cha #Immunology #Genetics #GWAS #Autoantibodies #Reactomics #MultiOmics #Biomarkers #PrecisionMedicine

Can a blood draw differentiate dementias? Bellomo et al. used plasma proteomics to distinguish AD, DLB & FTD. Adding antibody reactomics yields critical multi-omic insights into environmental drivers of neurodegeneration. rdcu.be/fAFt0 #Neurodegeneration #Proteomics #Reactomics #Biomarkers #Alzheimers #Dementia #LewyBody #FrontotemporalDementia #CohortOfTheWeek #MultiOmics

How stable is the proteome? A @NatureComms cohort study reveals disease onset reshapes protein stability—locking in normally variable signals. To track these dynamic shifts & past immune encounters, pair proteomics with antibody reactomics! rdcu.be/fzmKA #Proteomics #AgingResearch #Biomarkers #PrecisionMedicine #CohortOfTheWeek

Serum autoantibodies mirror central disease manifestations in AD, PD & MS, proving neurodegeneration is systemic! Broadly profiling self, viral & environmental reactivities unlocks new biomarkers. doi.org/10.1016/j.isci.2026.… #SystemsImmunology #Neurodegeneration #Proteomics #Reactomics #Biomarkers #Alzheimers #Parkinsons #MultipleSclerosis

A new study analyzed how ancestry & geography shape biology. Integrating multiomics with antibody responses to 37 microbial antigens provided key insights into how exposure history drives biological aging. doi.org/10.1016/j.cell.2026.… #Proteomics #MultiOmics #Microbiome #PrecisionMedicine #Reactomics #CohortOfTheWeek

Plasma proteomics can track cell-specific aging, but what drives it? By adding antibody reactomics to cohorts, we can map lifetime environmental exposures (viral, bacterial). This layers critical context onto proteomics to uncover what triggers cellular aging & chronic disease. [doi.org/10.1038/s41591-026-0…] #Proteomics #MultiOmics #CellularAging #Neurodegeneration #Reactomics #CohortOfTheWeek

A landmark study in Cell uses plasma proteomics to predict lung cancer 5+ years early. While proteomics tracks inflammatory drivers of cancer, adding antibody reactomics links potential infectious and environmental exposure triggers. [doi.org/10.1016/j.cell.2026.…] #Proteomics #MultiOmics #CancerPrevention #LungCancer

Metagenomics shows which gut microbes predict Type 2 Diabetes risk. But how does the host respond? By layering antibody reactomics, we can track exactly how the immune system monitors these diet-microbe shifts, unlocking the next frontier in early risk prediction. [doi.org/10.1016/j.xcrm.2026.…]

A new Nature Aging study of 5 major cohorts (incl. UK Biobank & ADNI) reveals how APOE2 & APOE4 shape Alzheimer’s risk. Massive, diverse human cohorts are essential for capturing these novel disease mechanisms. Read more: rdcu.be/fkVs9

Most systems immunology data lacks diversity, relying heavily on European ancestry. The new HHGP-HK Asian reference cohort (1,025 donors) changes that. Diverse human cohorts are essential to address data gaps, validate biomarkers, & discover novel disease associations globally.

Exploring the gut microbiome’s role in cancer, Usyk et al. analyzed 674 global melanoma patients. Large, diverse cohorts prove that geographic hurdles vanish when matching microbial fingerprints, unlocking more accurate, personalized immunotherapy. [doi.org/10.1016/j.cell.2026.…] #Microbiome #Melanoma #Immunotherapy #Biomarkers #PrecisionMedicine #CancerResearch #Reactomics

Precision medicine fails as a "one-size-fits-all." By leveraging the UCLA ATLAS Biobank, researchers integrated EHRs with genomic data from 90,000+ participants to uncover critical disease-gene links in diverse, underrepresented groups, driving new disease associations. doi.org/10.1016/j.cell.2026.… #PrecisionMedicine #Genomics #HealthEquity #UCLAATLAS

How do factors like age and genetics shape our immune defense? New study used antibody reactome profiling to map the human virome at unprecedented resolution. Reactivity data revealed how our "molecular diary" drives vaccine recall and autoimmune risk. [rdcu.be/ffcYk] #Immunology #PrecisionMedicine #AntibodyReactomics #NatureImmunology

A new Human Immune Health Atlas published in Nature reveals that immune aging is a non-linear process starting earlier than we thought. By mapping these molecular transitions, we can better tailor vaccines and therapies to biological age, not just the clock. [rdcu.be/fcrJT] #ImmuneAgeing #MultiOmics #HumanHealth #Immunology #SystemsBiology #Aging

New study in Nature shows immune ageing starts early with T cell reprogramming and GATA3 activity. Adding antibody reactome profiling to these cohorts can reveal the extrinsic viral and environmental triggers of ageing—a vital layer for the multi-omic stack. [rdcu.be/fcrJT] #ImmuneAgeing #MultiOmics #HumanHealth #Immunology #SystemsBiology #ImmuneHealthAtlas

A massive study of 2,279 brain samples reveals that neurodegenerative diseases share molecular drivers but have distinct subtypes. Integrating antibody reactome profiling could further bridge these gaps by uncovering the immune "history" and auto-reactivity linked to disease. [cell.com/cell/fulltext/S0092…] #Proteomics #MultiOmics #Neurodegeneration #PrecisionMedicine #CohortOfTheWeek

A new study in Nature Medicine reveals that IgG1 producing B-cells and plasma cells are central to anti-tumor immunity. Key findings: clonal IgG1 enrichment in tumors, trafficking between lymph nodes, and targeting of tumor antigens. A T-cell + humoral strategy could transform cancer outcomes. rdcu.be/e90xd #Immunotherapy #CancerResearch #Bcells #MultiOmics #BCRseq #AntibodyReactome #PrecisionMedicine #Oncology

A new @LifelinesNL study of 700+ mother-infant pairs maps dynamics and establishment of the gut virome. Key finding: maternal sharing & early viral diversity are linked to infant immune health and food allergies. Reactomics can now help us unlock how the host response in health and disease. doi.org/10.64898/2026.03.05.…

Thrilled to welcome Brian McKelligon as the new CEO of Infinity Bio! Brian is an accomplished life sciences leader and we could not be more excited to have him at the helm. His leadership will accelerate the reach of our MIPSA technology and the inSIGHTs it delivers to researchers worldwide. #InfinityBio #MIPSA businesswire.com/news/home/2…

New study offers a 25-year molecular map of MS progression. Key findings: EBV is an ongoing driver and sex-specific pathways impact phenotypic outcomes. Large-scale proteomics is vital to uncovering these hidden biomarkers and mechanisms for early intervention. Read here: rdcu.be/e7ZWe #MultipleSclerosis #MSResearch #EBV #Biomarkers #PrecisionMedicine #Proteomics #MultiOmics #Reactomics