The Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, neurobiology. Est. 1896 - @RockUPress
New York, NY
Joined September 2009
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Journal of Experimental Medicine retweeted
My first-author paper is now live @JExpMed! We found that the Alzheimer's disease risk factor CASS4 is a critical regulator of amyloid beta plaque compaction, microglial mobilization to damage, and focal adhesion signaling.
rupress.org/jem/article/223/…
Journal of Experimental Medicine retweeted
New study from our group @Addie_E_Walsh 👇
Alzheimer’s genetic risk factor CASS4 controls microglial focal adhesion biology and amyloidosis @JExpMed rupress.org/jem/article/223/… #Alzheimer
Journal of Experimental Medicine retweeted
Thrilled to share our new Review on how to make a cold tumor hot, published in the Journal of Experimental Medicine @RockUPress
rupress.org/jem/article/223/…
Journal of Experimental Medicine retweeted
Online today in @JExpMed,
doi.org/10.1084/jem.20251898
TLDR: a genetically-defined group of osteosarcoma is sensitive to the EP300 PROTAC JQAD1, due to a balance between degradation and resynthesis by the ribosome. Read on for deets...
Journal of Experimental Medicine retweeted
New research published in @JExpMed from @DanaFarber’s @JunQiLab and collaborators reveals that AKT inhibitors synergize with EP300 degraders to suppress osteosarcoma growth in vitro and in vivo. These agents positively combine across cancer cells in a manner dependent on control of protein synthesis.
➡️bit.ly/4z13y9G
Journal of Experimental Medicine retweeted
1/ We are excited to share our new paper in @JExpMed!
doi.org/10.1084/jem.20251245
Here we show that α-synuclein, a protein involved in Parkinson’s disease, triggers inflammation at CNS borders and impairs CNS clearance.
Journal of Experimental Medicine retweeted
Excited to share our work in @JExpMed led by @t_stevenson95. We show that aggregated α-synuclein at CNS borders drives inflammation and impairs lymphatic function, positioning meningeal immunity as a driver of clearance deficits in Parkinsons disease.
tinyurl.com/5yvpsxhm
Journal of Experimental Medicine retweeted
So exciting to have this paper online @JExpMed . thanks for the wonderful collaboration with @ADurbinLab @TheAbraLab, Ory lab. Congratulations on all the team members.
The first authors are: Ian M. Delahunty, Stephanie Nance, Yang Zhang, François Lamoureux, and Qi Liu.
From Ory lab @NantesUniv, @JunQiLab @DanaFarber, @TheAbraLab, and @ADurbinLab @MolOnc_StJude @StJudeResearch @StJudegraduate
Journal of Experimental Medicine retweeted
It was a lot of fun working on this perspective with @SimonRoyMD & the other Irving Symposium trainees. We are excited to share what we have learned with others who are preparing to transition or who have started their groups!
Roy et al. posit that scientific independence alone is insufficient to build a sustainable lab under uncertain funding & offer practical guidance for defining a research vision, allocating resources, navigating funding opportunities & supporting trainees hubs.la/Q04zV5DW0
Journal of Experimental Medicine retweeted
Retweets appreciated! Natural microbiota-based mouse models - particularly Wildlings - improve reproducibility & translation across a remarkable range of biomedical fields. Our new @JExpMed Found in Translation! Thanks Isabel, Mario & @jonatcoquet! doi.org/10.1084/jem.20261517
Journal of Experimental Medicine retweeted
🔬NEW RESEARCH -How do our #cells maintain rapid bursts of #inflammation to fight #pathogens? 🔥 In this new #collaborative #paper with Prof Xiaopeng Qi @JExpMed, we show that the inflammatory signalling control centre within the cell, called the inflammasome, must be fueled. 1/3
ALT Vps4B controls caspase-1 dynamics at the ASC speck to drive inflammasome activation
Journal of Experimental Medicine retweeted
4/ After leaving the lab, @ryangrui completed his pediatric residency at @WCMpeds and his Allergy and Immunology fellowship at @bcmhouston and @TexasChildrens. Our ongoing collaboration has yielded a study in @JExpMed on RORγT deficiency rupress.org/jem/article/223/…
Journal of Experimental Medicine retweeted
1/ Delighted to share our paper in @JExpMed today, led by @IrisFagniez and @ryangrui, two trainees who have both recently started exciting new chapters in their careers: MD-PhD training at @harvardmed @MIT and Assistant Professorship at @bcmhouston!
rupress.org/jem/article/223/…
Journal of Experimental Medicine retweeted
New in @JExpMed: By tracking LAG3-expressing T cells for the first time, @Vignali_Lab showed that exhausted cells can lose LAG3, leave the tumor, and prevent cancer recurrence. Read more: immunology.pitt.edu/news/t-c…
ALT Screenshot of paper, "Tumor-reactive LAG3+CD8+ T cells diverge into terminally exhausted cells and long-lived memory T cells" published in the Journal of Experimental Medicine by Dr. Dario Vignali and colleagues.
Journal of Experimental Medicine retweeted
🎉 Very excited to share that my first first-author paper is now out in the Journal of Experimental Medicine! (@JExpMed) doi.org/10.1084/jem.20252357
📹 Short video summary: youtube.com/watch?v=O0v87xz-…
@WWIEM_QUB
@QUBelfast
Journal of Experimental Medicine retweeted
ADCs are transforming solid tumor care, and many exciting innovations are coming! 🎯
In this review, mentored by Dr. Meric-Bernstam, we discuss key design principles, resistance mechanisms, and 7 promising ADC combination partners. 👇 #Oncology #ADC @JExpMed @UTMDAnderson
.@Nakul2234 and Meric-Bernstam @UTMDAnderson review the rapidly evolving landscape of antibody–drug conjugates for #SolidTumors. The authors evaluate major design components, clinical efficacy of approved agents, & determinants of response and resistance. hubs.la/Q04qFtTq0
Journal of Experimental Medicine retweeted
Out today in @JExpMed: sensory nerves activate peritoneal mast cells, which extend 100 µm cytonemes to hand extracellular condensates to macrophages — driving aggregation and repair at abdominal injuries. With @MonicaAidaLopez, @Kubes_Lab & a wonderful team 🧵
Salm, Lopez, Kubes et al. @UCalgary @queensu reveal that peritoneal #mastcells, activated by sensory neurons, extend #cytonemes that hand off extracellular condensate to neighboring #macrophages, driving rapid aggregation & a repair phenotype. hubs.la/Q04qkmg20
Journal of Experimental Medicine retweeted
Latest from us. :)
Conor Gruber, @BogunovicLab @KidsAtColumbia et al. identify #STAT2 mutations in a family with severe early-onset pulmonary alveolar proteinosis (PAP), a rare lung disease marked by alveolar surfactant accumulation. hubs.la/Q04pM_cP0
Journal of Experimental Medicine retweeted
1/ We are delighted to share our work published in @JExpMed identifying homozygous rare and common IL23Rhypomorphic variants underlying tuberculosis
(doi.org/10.1084/jem.20252236).
Journal of Experimental Medicine retweeted
Excited to share new research from PICI Center Director @wolchokj, PICI researchers Taha Merghoub, Mohamad Hamieh, and other researchers from @WeillCornell Medicine, where they highlight a promising new approach to treating bladder cancer.
Published in the @JExpMed, the study identifies MUC16 as a promising target for CAR T cell therapy and demonstrates that delivering CAR T cells directly into the bladder effectively controls tumors in preclinical models while minimizing systemic toxicity.
These findings could help pave the way for new bladder-sparing treatment options for patients with therapy-resistant disease.
Learn more here: rupress.org/jem/article/223/…
