@AvHStiftung postdoctoral fellow @DLawsonlab & @Kessenbrocklab. PhD @DKFZ/@hi_stem_lab. Breast Cancer | Metastasis | Therapy resistance | Single cell genomics
Irvine, CA
Joined January 2017
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Why is multi-organ #metastasis so hard to treat? Is it organ ("soil")-specific or is there a #systemic program we’ve missed? 🚨 Our new preprint on @biorxiv_cancer reveals a universal, targetable niche conserved across the body. biorxiv.org/content/10.64898… 🧵👇
💊The encouraging news: We can break the circuit. Interference of the MIF-CD74 axis attenuates T cell exhaustion and impairs metastasis systemically. It’s a single target for a multi-organ problem.🎯
Immensely grateful of this team effort! Thanks to @DLawsonlab & @KessenbrockLab fellows, collaborators at @UCIrvineHealth @UCIMedSchool @UCIrvine @CCBS_UCI, @masrilab, @cholsoon_jang, support from @AvHStiftung; @MetastasisRS, @ASEICAnews; and metastatic breast cancer #patients.
Jacob Insua-Rodríguez retweeted
Single-cell profiling of synchronous multi-organ metastasis reveals a systemic CD74+ lipid-associated macrophage niche driving ... biorxiv.org/content/10.64898… #biorxiv_cancer
Jacob Insua-Rodríguez retweeted
🚨 Exciting Opportunity Alert! 🚨
Are you passionate about understanding why cancer patients relapse and uncovering the secrets of tumor dormancy and metastasis?
Join our dynamic lab @templemedschool and @FoxChaseCancer
✨ Please RT to spread the word! ✨
Check out our latest preprint, where we uncover the pro-metastatic function of PHLDA2, with interesting links to embryonic development. #metastasis @UCIrvine
Check out our new paper identifying the developmental gene PHLDA2 as a robust driver of breast cancer metastasis! Thanks to @PHalasPhD @hannysavage @_DennisMa @KessenbrockLab for all their hard work, and support from @AmericanCancer, @theNCI, & Team Michelle. @UCIMedSchool
Jacob Insua-Rodríguez retweeted
Check out our new paper identifying the developmental gene PHLDA2 as a robust driver of breast cancer metastasis! Thanks to @PHalasPhD @hannysavage @_DennisMa @KessenbrockLab for all their hard work, and support from @AmericanCancer, @theNCI, & Team Michelle. @UCIMedSchool
PHLDA2 promotes breast cancer metastasis by co-opting a developmental program for placental vascular remodeling biorxiv.org/content/10.1101/… #biorxiv_cancer
Jacob Insua-Rodríguez retweeted
Excited to share the preprint of my doctoral work investigating the role of placental development gene PHLDA2 in breast cancer metastasis @DLawsonlab
PHLDA2 promotes breast cancer metastasis by co-opting a developmental program for placental vascular remodeling biorxiv.org/content/10.1101/… #biorxiv_cancer
Jacob Insua-Rodríguez retweeted
If you work in cancer… this is the congress to go, enjoy top notch science and have fun (at a football stadium 😉)
#ASEICACongress
@ASEICAnews
🛑20th #ASEICACongress
📅8-10 OCT
Bilbao(Spain)
KEYNOTE🗣️
✅J. Joyce(@unil)
✅Y.Samuels(@WeizmannScience)
✅A.Bardelli(@fpoirccs)(@BardelliLab)and➕
New markers🔬
✅Tumor progression mechanisms
✅Cutting-edge treatments and technologies
✅Diet and🏃
📘aseica.es/20th-aseica-intern…
Jacob Insua-Rodríguez retweeted
I’m not biased: our first #ASEICAInternational Networking seminar was a success: for the engagement of our speakers (María Alieva, Jacob Insua and @asalboix) and for the many partipants in Spain and abroad.
If you work in cancer and not a member yet, join right away!@ASEICAnews
📍It's time for the I ASEICA-International Networking Seminar:Tumor Microenvironment
1⃣0⃣0⃣participants‼️
✅Cross-disciplinary exchange–From TME to IO, let’s bridge gaps
📢Outstanding speakers:@asalboix (U. of Basel); Jacob Insua(UC Irvine);Maria Alieva (@IIBmCSICUAM)
Thanks!
It was a pleasure to participate - thanks a lot for the invitation! Looking forward to more events like this. ASEICA-International is a great initiative!
📍It's time for the I ASEICA-International Networking Seminar:Tumor Microenvironment
1⃣0⃣0⃣participants‼️
✅Cross-disciplinary exchange–From TME to IO, let’s bridge gaps
📢Outstanding speakers:@asalboix (U. of Basel); Jacob Insua(UC Irvine);Maria Alieva (@IIBmCSICUAM)
Thanks!
Jacob Insua-Rodríguez retweeted
📍It's time for the I ASEICA-International Networking Seminar:Tumor Microenvironment
1⃣0⃣0⃣participants‼️
✅Cross-disciplinary exchange–From TME to IO, let’s bridge gaps
📢Outstanding speakers:@asalboix (U. of Basel); Jacob Insua(UC Irvine);Maria Alieva (@IIBmCSICUAM)
Thanks!
Jacob Insua-Rodríguez retweeted
Do you want to find future collaborators, a host laboratory to obtain the international PhD mention or strengthen your scientific network? Join #aseicainternational #aseicacomunicacion
Are you a cancer researcher in Spain willing to move abroad? Or are you working abroad and want to strengthen tights and create new research opportunities in Spain? Then take a look at #ASEICAInternacional and sign up with QR code👇
bit.ly/4geGD0e
@ASEICAnews
Jacob Insua-Rodríguez retweeted
Ofertamos plaza de Técnico de Laboratorio PEJ-2024-TL/SAL-GL-33015: sitios.csic.es/web/sede/conv…
Los interesados tienen del 14 al 27 de enero para presentar lassolicitudes. Los aspirantes deberán acceder a la aplicación CONVOCA y seguir los pasos indicados: convocatorias.csic.es/convoc…
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Jacob Insua-Rodríguez retweeted
🔔We're hiring a Research Technician to join our team!
The ideal candidate will be down to work w/mice and human tissues, be available to join us for at least 2years, and enjoy being a part of an ambitious team.
Apply: correialab.com/join-the-team…
Funded by @CaixaResearch
@Neuro_CF
Jacob Insua-Rodríguez retweeted
🚨 Exciting Opportunity Alert! 🚨
Are you passionate about understanding why cancer patients relapse and uncovering the secrets of tumor dormancy and metastasis?
Join our dynamic lab @FoxChaseCancer @templemedschool!
We're looking for a postdoc to join our mission of tackling cancer relapse and metastasis.
📩 Email or DM me to apply! Let’s push the boundaries of cancer biology together.
✨ Please RT to spread the word! ✨
