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Justin Kim

@JKimLab

Asst. Professor of Biological Chemistry and Molecular Pharmacology at Dana-Farber Cancer Institute/Harvard Medical School

 Boston, MA
kimlab.dana-farber.org
Joined October 2018
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  • Followers386
Check out our latest paper by @JSiriwongsup and co-workers in Chem: doi.org/10.1016/j.chempr.202…. It describes bioorthogonally activated reactive species (BARS) that are highly effective for target ID. We exploit haloiminium ions derived from enamine N-oxides. #bioorthogonal #targetID
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Also, I completely forgot to tweet out Dr. Elaine Fowler’s recent Chem paper on chemically revertible molecular clasps for peptide macrocyclization and linearization doi.org/10.1016/j.chempr.202…. She did an awesome job, and I want to make sure she gets a proper shoutout. #macrocycles
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Congratulations to @DanaFarber @JKimLab on being awarded a prestigious @NSF Career Faculty Early Career Development Award to explore the Synthesis and Application of Bioorthogonally Degradable Polymers Read more here ⤵️ nsf.gov/awardsearch/showAwar….
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Check out our latest paper in Chem describing a paired set of associative and dissociative bioorthogonal transformations enabling not only protein bioconjugation but also its rapid, traceless reversion! @Chem_CP doi.org/10.1016/j.chempr.202…
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Check out our new paper describing a rapid and regioselective bioorthogonal reaction between cyclooctynes and hydroxylamines via the retro-Cope elimination reaction in @J_A_C_S @CarolynBertozzi pubs.acs.org/doi/10.1021/jac…
Bioorthogonal Retro-Cope Elimination Reaction of N,N‑Dialkylhydroxylamines and Strained Alkynes

Bioorthogonal Retro-Cope Elimination Reaction of N,N‑Dialkylhydroxylamines and Strained Alkynes

Abstract. A bioorthogonal reaction between N,N-dialkylhydroxylamines and cyclooctynes is described. This reaction features a highly regioselective transfor

pubs.acs.org
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Our report describing the use of enamine N-oxides in hypoxia-responsive prodrug and imaging applications also just came out in @ACSCentSci pubs.acs.org/doi/abs/10.1021…
Enamine N‑Oxides: Synthesis and Application to Hypoxia-Responsive Prodrugs and Imaging Agents

Enamine N‑Oxides: Synthesis and Application to Hypoxia-Responsive Prodrugs and Imaging Agents

Abstract. Tumor hypoxia induces the large-scale adaptive reprogramming of cancer cells, promoting their transformation into highly invasive and metastatic

pubs.acs.org
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We're hiring postdocs in multiple project areas in chemistry and chemical biology. If you are interested in protein-protein interactions, tumor hypoxia, reaction development, or med chem, email me your CV and research summary. kimlab.dana-farber.org/caree….
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