Jake Boles (@JS_Boles) profile picture

Jake Boles

@JS_Boles
Joined March 2022
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  • Following150
  • Followers70
Thank you @IUMedSchool for show casing our work in my wonderful mentors lab @MaluTansey This is just the tip of the ICEberg! medicine.iu.edu/blogs/resear… – at Indianapolis, IN
Parkinson's researchers discover 'tip of the ICE-berg' on quest for a cure

Parkinson's researchers discover 'tip of the ICE-berg' on quest for a cure

Parkinson's researcher Malú Tansey brings cell-level science to IU’s already strong clinical research program. Her lab engages in "paradigm-shifting work" studying inflammation and immune response in...

medicine.iu.edu
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Please join us in congratulating the fall semester graduates of our PhD program: Jake Boles, Ben Kidd, Dylan Guenther, Alejandro Albizu, Anthea Bu, and Zak Krumm! #Neuroscience #UFNeuro #GoGators
Image from University of Florida Department of Neuroscience (@UFNeuroscience)
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🚨NEW PRE-PRINT ALERT🚨 We show, for the first time, that the R1441C LRRK2 mutation induces myeloid cell immune-exhaustion in an age- & sex- dependent manner in KI mice, with these phenotypes also observed in patient cells. 🧵 biorxiv.org/content/10.1101/…
The R1441C-LRRK2 mutation induces myeloid immune cell exhaustion in an age- and sex-dependent manner

The R1441C-LRRK2 mutation induces myeloid immune cell exhaustion in an age- and sex-dependent manner

Considering age is the greatest risk factor for many neurodegenerative diseases, aging, in particular aging of the immune system, is the most underappreciated and understudied contributing factor in...

biorxiv.org
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My first first-author manuscript is online at #biorxiv_neursci! See below as we appraise the kinetics of inflammation and injury in a popular mouse model of colitis, from gut to blood to brain. Thanks to @UriarteOihane @MaluTansey & all other authors! biorxiv.org/content/10.1101/…
A leaky gut dysregulates gene networks in the brain associated with immune activation, oxidative...

A leaky gut dysregulates gene networks in the brain associated with immune activation, oxidative...

The gut and brain are increasingly linked in human disease, with neuropsychiatric conditions classically attributed to the brain showing an involvement of the intestine and inflammatory bowel...

biorxiv.org
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✨excellent✨ talk on the role of progranulin on BMP metabolism by our very own @GillettDrew 🧑‍🔬 at the #KSNeuroImmune22 #KSNeurodegen22 joint meeting - so proud 🌈 – at Keystone, CO
Image from Dr. Rebecca Wallings (@RebeccaWallings)
Image from Dr. Rebecca Wallings (@RebeccaWallings)
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First full day of #ADPD2022 and the posters are up 📌✨ come by 288, 424 (@UriarteOihane) and 386 (@JS_Boles) to hear about research from the @MaluTansey lab 🥼🧫🔬 – at Barcelona, Spain
Image from Dr. Rebecca Wallings (@RebeccaWallings)
Image from Dr. Rebecca Wallings (@RebeccaWallings)
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