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1/ Today in @NatureBiotech, we published the first DNA-guided CRISPR that we originally reported in our 2024 preprint for detecting and targeting RNA in cells
medrxiv.org/content/10.1101/…
Piyush Jain retweeted
Just a typical day....when you see the first DNA computer
nature.com/articles/s41586-0…
Piyush Jain retweeted
The @FDA approves @moderna_tx's mFlusiva, the first seasonal flu vaccine to use mRNA-based production, which allows vaccines to be quickly updated to match circulating influenza strains and could result in improved protection nature.com/articles/s41587-0…
rdcu.be/h6wBbwogSsya
Piyush Jain retweeted
5/5 🚀 Why This Matters: Synthetic DNA guides are significantly cheaper and far more durable than RNA guides. Unlocking DNA-guided RNA targeting opens up practical possibilities for fast, low-cost diagnostic tests.
Bonus @JainLaboratory work at tinyurl.com/3xvbt2f5
Piyush Jain retweeted
1/5 🇮🇹 Excited to share this amazing work published in @NatureSMB with @JainLaboratory, led by talented grad students Rodrigo Fregoso Ocampo and @oroscocarlos15.
nature.com/articles/s41594-0…
1/5: Thrilled to share this exciting work on the high-resolution structure of DNA-guided CRISPR with David Taylor @davidwtaylorjr released today in @NatureSMB
led by talented grad students Rodrigo Fregoso Ocampo and Carlos Orosco @oroscocarlos15
🧵👇
nature.com/articles/s41594-0…
4/5 ⚡ The Built-In Speed Control: Not all DNA loops are created equal! The 3D structure revealed that matching specific sequence patterns in the hairpin (acting like a PAM key) turns the system on. Using an optimized "TTTA" motif acts like an accelerator, speeding up target cutting drastically.
Such a wonderful collaboration with @davidwtaylorjr Photo taken today in Naples, Italy 🇮🇹
Piyush Jain retweeted
Natureに論文が出ました。
nature.com/articles/s41586-0…
「ブリッジRNAは環状化後に作られるのに、その環状化にもブリッジRNAが必要」という“鶏が先か、卵が先か”問題を解き、IS621転移因子がゲノムから切り出される仕組みを明らかにしました。
一緒に研究してくださった皆様に感謝です。
Piyush Jain retweeted
Today in @NatureBiotech we report OptiPrime, a mechanism-based machine learning model for predicting prime editing (PE) efficiencies and suggesting pegRNAs to achieve a user-specified edit. OptiPrime incorporates biochemical knowledge about PE into its mathematical structure, enabling training on ~300,000 PE efficiencies collected using 40 experimental conditions in multiple labs, and outcome predictions of PE variants such as twin prime editing not used in its training. OptiPrime enabled the rapid identification of efficient PE strategies across a variety of applications in vitro and in vivo, and could outperform months or years of manual experimental optimization.
Try out OptiPrime here: optipri.me
PDF: drive.google.com/file/d/13JZ…
1/15
Another wonderful collaboration with David Taylor's group led by Kaoling Guan @KGuan7 and Nathan Appleby. Check out this exciting preprint detailing the #cryo-EM structure and mechanism of of TasA and TasH involved in #TIGR-Tas systems.
biorxiv.org/content/10.64898…
Check out our exciting new work on TasA and TasH structures! Great work by @KGuan7 and Nathan Appleby. Another fun collaboration with @PiyushGoyal!
biorxiv.org/content/10.64898…
Piyush Jain retweeted
Check out our exciting new work on TasA and TasH structures! Great work by @KGuan7 and Nathan Appleby. Another fun collaboration with @PiyushGoyal!
biorxiv.org/content/10.64898…
Piyush Jain retweeted
New-found immune cells called ‘ruptoblasts’ explode when triggered, ejecting toxic chemicals capable of delivering death to surrounding cells in just minutes. The cells’ discoverers say that this process, which they call ruptosis, seems to be a new form of cell death.
go.nature.com/4x3SZBT
Piyush Jain retweeted
One of the most amazing things I’ve ever seen: a standing ovation for the full Daraxonrasib results
I feel inspired and energised, to put it mildly — we have a targeted therapy for pancreatic cancer now, and nothing is undruggable anymore
Piyush Jain retweeted
DNA-guided CRISPR breakthrough could reshape RNA editing and diagnostics #NBTintheNews via @pulse2news pulse2.com/university-of-flo…
