
Starting PI at @CharlesUniPRG🇨🇿, former @karolinskainst🇸🇪 postdoc, @czexpats🌍. Notch & Wnt in development and disease 🔬🧫🐁. *All views my own; 🇪🇺🇺🇦
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ALT Figure 4 The consequence of a loss in lumen anisotropy on hepatoblast differentiation. Hepatoblasts differentiate via default and directed pathways into hepatocytes and cholangiocytes, respectively. Here, we demonstrate that the loss of lumen anisotropy, and the acquisition of vectorial polarity, impairs the ongoing default differentiation programme. This results in the formation of vectorially polarized cells with a mixed hepatocyte-cholangiocyte gene expression profile, which we termed vectorial hepatocytes. Green represents subapical actomyosin cortex. Pink represents nuclei containing Sox9.
































