A computational biology lab at UCLA
Los Angeles, CA
Joined June 2019
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Jason Ernst Lab retweeted
What distinguishes successful from failed reprogramming to iPSC? In this new preprint, part of our @IGVFConsortium efforts, we used single cell methylation, Hi-C, RNA and ATAC, and spatial RNA to answer this question biorxiv.org/content/10.64898…
Jason Ernst Lab retweeted
🔔 We are hiring! 🔔 We are looking for great colleagues doing curiosity driven research at the molecular level across broad areas of science. Please consider applying and spread the word!
recruit.apo.ucla.edu/JPF1130…
Jason Ernst Lab retweeted
The peer-reviewed version of map3C, a tool developed by Joseph Galasso (co-advised by @jernst98) to more accurately map snm3C-seq data and enable robust 3D conformation modeling, has been published in OUP Bioinformatics. doi.org/10.1093/bioinformati…
Jason Ernst Lab retweeted
I am a guest editor with Martha Bulyk and Katie Pollard of a Genome Biology special collection on "Prioritizing non-coding variants"
Link for more information: link.springer.com/collection…
Submission deadline: November 25, 2026.
Jason Ernst Lab retweeted
MissenseHMM: state-based annotations for missense variants through joint modeling of pathogenicity scores biorxiv.org/content/10.64898… #biorxiv_genomic
Jason Ernst Lab retweeted
We are excited to release a single-cell and spatial 3D epigenomic atlas of developing human basal ganglia and inhibitory neurons, part of our BICAN effort in collaboration with @lab_paredes @jernst98 @emukamel @CEpigenomics @bpasaniuc
biorxiv.org/content/10.64898…
Jason Ernst Lab retweeted
Thanks to @ferhatay and Aly Khan, we’re excited to announce a new chapter for RECOMB-RSG 2026. After years with ISCB/DREAM, we are transitioning to an official RECOMB satellite meeting (May 25 in Thessaloniki). recomb-rsg.github.io
Jason Ernst Lab retweeted
We like to introduce map3C, developed by Joseph Galasso, that drastically improves the mapping and contact calling performance of snm3C-seq and now enables accurate 3D genome modeling. map3C was developed in collaboration with @jernst98 and Frank Alber biorxiv.org/content/10.1101/…
Jason Ernst Lab retweeted
📣New from Li et al!
📄Whole genome sequence-based association analysis of African American individuals with bipolar disorder and schizophrenia
👉bit.ly/4lWks1M
Jason Ernst Lab retweeted
GECSI: Large-scale chromatin state imputation from gene expression biorxiv.org/content/10.1101/… #biorxiv_bioinfo
Jason Ernst Lab retweeted
Genome-wide identification and analysis of recurring patterns of epigenetic variation across individuals: Communications Biology, Published online: 07 June 2025; doi:10.1038/s42003-025-08179-5Recurring genome-wide patterns of epigenetic mark variation… nature.com/articles/s42003-0…
Jason Ernst Lab retweeted
Will comparative biology crack the epigenetic code to longevity? New imputed DNA methylation dataset covers 59 tissues from 348 mammals including long living species such as bowhead whale (211 years), bats, and the naked mole rat. Which tissue holds the key to longevity? Which genes, CpGs, and genomic regions? Cutting-edge imputation applied to data from the Mammalian Methylation Consortium.
Emily Maciejewski, Jason Ernst (2025) CMImpute: cross-species and tissue imputation of species-level DNA methylation samples across mammalian species. Genome Biology. pmc.ncbi.nlm.nih.gov/article…
@JasonErnstLab
@eamaciejewski
#epigenetics #compbio #longevity
Jason Ernst Lab retweeted
Perspective on recent developments and challenges in regulatory and systems genomics academic.oup.com/bioinformat… is out, amazing to think about this with @JuliaZeitlinger, @ferhatay, @mahonylab, @AMathelier, @AleMedinaRivera, @jernst98!
Jason Ernst Lab retweeted
Here is a press release by @UCLAHealth that nicely summarizes the key findings from our paper published today @CellCellPress. uclahealth.org/news/release/…
Jason Ernst Lab retweeted
Happy to share our new paper published today @CellCellPress. Thanks to all our coauthors from @dgsomucla, @UCLASemel, and CHDI.
Distinct mismatch-repair complex genes set neuronal CAG-repeat expansion rate to drive selective pathogenesis in HD mice: Cell cell.com/cell/fulltext/S0092…
Jason Ernst Lab retweeted
Learning a Pairwise Epigenomic and Transcription Factor Binding Association Score Across the Human Genome biorxiv.org/cgi/content/shor… #biorxiv_bioinfo
Jason Ernst Lab retweeted
Faculty Position in UCLA’s School of Medicine: Broad search in Biomathematics, Biochemistry, Genetics, Pharmacology, Neurobiology, Physiology, Microbiology, Immunology. We seek exceptional scientists committed to research and mentorship. Apply by Jan 19 recruit.apo.ucla.edu/JPF1006…
Jason Ernst Lab retweeted
After many zoom meetings, discussions & learning from one another about different ways to look at the same data/problem, our perspective article on regulatory genomics is out. We have a “hallmarks of gene regulation” figure which i am planning to use in my talks. Enjoy reading!
Delighted to have worked on this perspective on the cis-regulatory code with @JuliaZeitlinger, @JasonErnstLab, @ferhatay, @AMathelier, @AleMedinaRivera, @mahonylab, @sinhasaur arxiv.org/abs/2411.04363. We provide an overview of current progress and some challenges to think about.
Jason Ernst Lab retweeted
It was great taking part in writing this perspective on the cis-regulatory code with such excellent scientists.
@iscb @ISCB_RegSys has provided us an outstanding platform to share and discuss these topics over the years. Let's keep up the great work in this fantastic community.
Delighted to have worked on this perspective on the cis-regulatory code with @JuliaZeitlinger, @JasonErnstLab, @ferhatay, @AMathelier, @AleMedinaRivera, @mahonylab, @sinhasaur arxiv.org/abs/2411.04363. We provide an overview of current progress and some challenges to think about.
Jason Ernst Lab retweeted
Delighted to have worked on this perspective on the cis-regulatory code with @JuliaZeitlinger, @JasonErnstLab, @ferhatay, @AMathelier, @AleMedinaRivera, @mahonylab, @sinhasaur arxiv.org/abs/2411.04363. We provide an overview of current progress and some challenges to think about.