We are a group of scientists & physicians passionate about #epigenetics #metabolism #genomics #leukemia #hematopoiesis #erythropoiesis #cancer #stemcells
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Joined February 2018
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Jian Xu retweeted
That’s a wrap on our @ForbeckForums on Nuclear Condensates in Cancer! Amazing group, fantastic science, and thought-provoking discussions in beautiful Pacific Grove! A great pleasure co-organizing this with @bsabari. Many thanks to @ForbeckForums for making this possible!
Jian Xu retweeted
St. Jude has named Charles W.M. Roberts, MD, PhD, internationally recognized physician-scientist and director of the St. Jude Comprehensive Cancer Center, as its seventh president and CEO. The announcement is part of a planned leadership transition.
Under his leadership, the Cancer Center has grown in scope and impact, earning the National Cancer Institute’s top “Exceptional” rating in both reviews and the best score in institutional history each time.
Dr. Roberts’ background in cancer epigenetics, clinical care and collaborative leadership has helped shape major efforts that connect researchers, clinicians and partner institutions to move discovery forward.
Jian Xu retweeted
Now online: Transposable Element Activation: A Hallmark of Cancer doi.org/10.1158/2159-8290.CD…
We are recruiting a postdoctoral fellow to study how metabolic pathways regulate normal and malignant hematopoiesis. Come join us!👉
stjude.wd1.myworkdayjobs.com…
Jian Xu retweeted
Erasmus Hematology Lecture, April 20th at 16.00 CET!
Speaker: Jian Xu, from St. Jude Children’s with
"Enhancer therapy in the era of genome editing"
Link: us06web.zoom.us/j/8427366092…
ID: 842 7366 0925
Spread the news!
Jian Xu retweeted
We are excited to announce the full Mini Symposium program featuring the short talks selected from submitted abstracts! Don't miss the chance to view groundbreaking research and choose the top short talk. View the full program and register ➡️ iseh.org/Webinars-Events/Min…
Jian Xu retweeted
ICYMI in @CD_AACR: LINE-1 Locus Transcription Nucleates Oncogenic Chromatin Architecture - by @thechuan3, @YuannyuZhang, @JianXuLab, and colleagues @StJudeResearch
Now online: LINE-1 Locus Transcription Nucleates Oncogenic Chromatin Architecture doi.org/10.1158/2159-8290.CD…
Jian Xu retweeted
Grateful to @JianXuLab for this perspective highlighting how oncogenes, developmental ontogeny, and cellular plasticity intersect in pediatric leukemia, alongside the JMML study by @mp_hartmann and @dblipka1. @BCD_AACR @CD_AACR aacrjournals.org/bloodcancer…
Jian Xu retweeted
Now online: LINE-1 Locus Transcription Nucleates Oncogenic Chromatin Architecture doi.org/10.1158/2159-8290.CD…
Jian Xu retweeted
Scientists discovered cancer cells use interactive LINE-1 retrotransposon regions to reshape 3D genome architecture, enhancing oncogenic gene expression. This mechanism links LINE-1 activity to cancer development & highlights potential therapeutic targets. ow.ly/qVN650XS0MN
Excited to share our new study published online today @CD_AACR. Beyond mutagenesis, we show that LINE-1 locus-specific transcription reshapes 3D genome architecture to control cancer gene expression @JianXuLab @StJudeResearch
aacrjournals.org/cancerdisco…
Take-home message: Cancer cells exploit LINE-1 not only for mutagenesis but also to rewire 3D genome architecture through locus-specific transcription, supporting a non-genetic mechanism of oncogenesis and a rationale for the frequent retrotransposon reactivation in cancer.
Kudos to @thechuan3 @CRI_UTSW @UTSWmstp and @YuannyuZhang @JianXuLab for their perseverance and confidence. We thank Ralph DeBerardinis and support from @theNCI @NIDDKgov @StJudeResearch, as well as the constructive feedback from reviewers and editors at @CD_AACR.
A proud moment for our own Jason Xu presenting his work from #POE summer research with Jun J. Yang @StJudeResearch one the big stage #ASH25! I was 31 when giving my first ASH talk. He did it 11 years earlier 😎😆
Huge congratulations to @farhanetal and @KailiWang_1 on fantastic presentations at their first ASH meeting #ASH25, representing @JianXuLab @StJudeResearch brilliantly. The engaging discussions sparked many great insights-well done!
