@JonWCunningham

Heart Failure Cardiologist & Investigator, @BrighamWomens @harvardmed @broadinstitute AI to Improve Cardiovascular Clinical Trials & Care

 Boston, MA
connects.catalyst.harvard.edu/Profiles/display/Person/89848
Joined February 2018
  • Tweets433
  • Following523
  • Followers1.1K
37Media
Can AI automate HF adjudication in global clinical trials? Our latest #AHA2024 SimPub @CircHF In the DELIVER trial, our AI model for HF hosp was -Accurate -Generated identical treatment estimate for dapa as human CEC -Extracts evidence of HF Paper: twtr.to/7qxb_
2
15
50
5,501
Jon Cunningham retweeted
Ron Blankstein
@RonBlanksteinMay 4
The brilliant ⭐️David Morrow delivering @MassGenBrigham HVI Grand Rounds on history and evolving role of CICU, training pathways, research challenges, and opportunities for improving care. High intensity staffing model --> better outcomes!
2
15
65
5,351
Jon Cunningham retweeted
Eric Topol
@EricTopolApr 26
An editorial by @HashemZikry @latimes @counselheatlh calling for more regulation of AI for patient use. Yes, there is "the staggering weight of unmet medical need," 1/3 Americans are using it to "diagnose symptoms and direct care," and states are moving in different directions. But the core problem now is lack of compelling proof of efficacy and safety, not the FDA. latimes.com/opinion/story/20…
17
76
3
175
22,629
Congratulations to Dr. Jennifer Ho on her promotion to Professor of Medicine @harvardmed! As Director of Research in our Division of Cardiovascular Medicine, she has been instrumental in empowering collaborative research to advance cardiovascular health 🌟 bit.ly/4sZJGjj
11
23
2
216
17,602
🚨New in @JACCJournals Can #CCTA stratify heart failure risk through radiomic phenotyping of epicardial adiposity? We derived & externally validated a deep radiomic signature of epicardial fat in >70,000 adults. w/ @Charis_Oxford on behalf of the #ORFAN consortium 🧵👇
1
13
2
69
6,128
Jon Cunningham retweeted
Henry Han
@HanCardiomd17 Dec 2025
Not All Hospitalized Heart Failure Patients Are the Same: A New Worldview jacc.org/doi/10.1016/j.jchf.… @JACCJournals
1
31
1
104
9,253
Replying to @CVCTForum
@CVCTForum is the best scientific meeting I have attended 🙌🏻 thanks @ZannadFaiez for the invitation! Great to catch up with @scottdsolomon & entourage Team #STRONG@HOME was well represented 😁- and the trial was highly relevant as digital care/ AI in CRM was the main topic
5
15
1,101
Thanks to hosts @DrMerkely & @KosztinMd for inviting me to speak at the Semmelweis University Symposium in Budapest on AI in cardiovascular care Enjoyed speaking with members of the Hungarian cardiology community and global colleagues like @NirUrielMD Photo @LuHenri8
2
3
10
586
Out today in @JACCJournals & #AHA25, led by @PabloMikiMarti Auto-MACE: automated AI adjudication model for MACE (CV death, MI, & stroke) Strong agreement with CEC in PARADISE-MI trial. Recognizes uncertain events. tinyurl.com/3w33dyec
1
6
15
3,019
Grateful our extended team @scottdsolomon @akshaydesaimd @SBadrouchi @patrick_ellinor @JenHoCardiology @broad_ml4h @MGBResearchNews @hfcollaboratory @coconnormd @lamcardio @hmkyale
3
179
Celebrating Women in Cardiology at AHA 2025 ❤️ An inspiring afternoon at @AHAScience #WIC Luncheon, where leaders, mentors, and future changemakers came together to celebrate excellence and equity in our field.
1
12
2
67
4,592
Doubleheader week for all-star nephrologist and mentee @SBadrouchi Spreading the word about improving CKM clinical trials with AI #KidneyWk: Generative AI for Event Adjudication #AHA25: Extracting individual symptoms, signs, and treatment from unstructured medical records
3
6
809
📢 Time for one of our most anticipated meetings of the year! Novel Statistical Concepts for HF Drug and Device Development Join us on November 14, 2025 | 8:45 a.m - 12:30 p.m. ET via Zoom Open to all — no HFC membership required Register here: hfcollaboratory.com/meetings…
7
13
1,708
🚨 New in @CircAHA : Maternal CVD and pregnancy-related CV complications are rising sharply over 2 decades across >56K pregnancies across @MassGenBrigham. Pregnancy is a critical window for lifelong heart health! 🔗doi.org/10.1161/CIRCULATIONA… @MGBResearchNews #CardioObstetrics
3
37
2
131
17,892
📢Personal update! ✨Thrilled to share that I’ll be moving my clinical practice to @BrighamWomens as Director of Women’s Heart Health. So grateful to my many mentors, colleagues & friends 🙏. Excited for this next chapter working to advance women’s 🫀 health! @MGBWomenHeart
38
15
3
421
38,339
Jon Cunningham retweeted
NEJM Evidence@NEJMEvidence30 Sep 2025
Flu causes major illness and death, but vaccination rates are falling. A large trial found that cardiovascular-focused nudges did not increase vaccination rates. In an accompanying editorial, the authors contextualize the findings. eviden.cc/3JFgTiW
“[KP-VACCINATE] is an excellent example of a pragmatic, population-wide nudge trial delivered through existing and widely available EHR technologies.” EDITORIAL Kaustav P. Shah, MD, and Srinath Adusumalli, MD, MSHP, MBMI

ALT “[KP-VACCINATE] is an excellent example of a pragmatic, population-wide nudge trial delivered through existing and widely available EHR technologies.” EDITORIAL Kaustav P. Shah, MD, and Srinath Adusumalli, MD, MSHP, MBMI

6
9
1,297
Jon Cunningham retweeted
CTCPR Trials & CIRL@CTCPR_5 Sep 2025
🚨 An extraordinary achievement from all the @CTCPR_ researchers at ESC! Our researchers simultaneously published 13 papers across leading journals, showcasing some of the latest breakthroughs in cardiology. These publications include: · 3 in The New England Journal of Medicine · 1 in The Lancet · 1 in JAMA · 2 in European Heart Journal · 3 in Journal of the American College of Cardiology · 1 in JAMA Cardiology · 1 in JAMA Open · 1 in Circulation: Heart Failure This remarkable achievement reflects the dedication and collaboration of the @CTCPR_ team. Each study contributes valuable insights that hopefully will help improve patient care and inform clinical practice worldwide. 👏 Huge congratulations to all @CTCPR_ researchers and collaborators for their hard work, perseverance, and commitment to advancing science. @NEJM @thelancet @JAMANetwork @ESC_Journals @JACCJournals @JAMACardio @JAMANetworkOpen @CircHF
6
2
22
3,918
How can AI enhance Clinical Trials? In latest @hfcollaboratory Heart of the Matter Podcast @coconnormd & panel share ideas on how to use AI to increase value/quality, design, patient selection, other aspects @mpsotka @dranulala @ankeetbhatt youtube.com/watch?v=r_urcTR_…
1
7
16
1,659
Jon Cunningham retweeted
Maja Cikes@MajaCikes31 Aug 2025
Delighted to have shared the results of ENVAD-HF as late-breaking science at #ESCCongress: 1st prospective RCT of #HeartFailure #GDMT #sacval in #LVADs: -numerically less primary outcome (death, ⬇️ renal fn, hypotn and hyperK) -safe, feasible, well tolerated -improved PROs
JACC Journals@JACCJournals31 Aug 2025
ENVAD-HF, a prospective RCT in stable HM3 #LVAD recipients, shows angiotensin–neprilysin inhibition is safe and well-tolerated, paving the way for trials of #HF therapies in this population. jacc.org/doi/10.1016/j.jchf.… #JACCHF #ESCCongress #WCCardio @MajaCikes @scottdsolomon
3
12
45
5,620
Jon Cunningham retweeted
NEJM Evidence@NEJMEvidence30 Aug 2025
In a large individually randomized trial embedded in routine care across a national U.S. health system, a cardiovascular-focused nudge intervention did not increase influenza vaccination rates on a background of low-uptake. Full trial results: eviden.cc/4mo2PZP #ESCCongress
Figure 2. Primary Outcomes of KP-VACCINATE.

ALT Figure 2. Primary Outcomes of KP-VACCINATE.

3
16
3
39
16,652
Load more