@JonathanClayden

Professor of Chemistry (molecular synthesis, shape, function). Amateur of growing, cooking, & eating things; of music, cycle-commuting, botany, & Oxford commas.

 Bristol, England
claydenchemistry.net
Joined June 2016
  • Tweets39
  • Following56
  • Followers3.2K
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Jonathan Clayden retweeted
WoolfsonLab@WoolfsonLab23 Jun 2022
Super excited that our work on the rational design of 310-helical bundles is now out in @Nature! Congrats Prasun @dgr8ashoka for this impressive piece you have led in collaboration with @ClaydenGroup and @DiamondLightSou! You can read it here: nature.com/articles/s41586-0…
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Marina Hyde's always good value but she's brilliantly on fire today. theguardian.com/commentisfre…

Farewell, Cressida Dick, the Met chief only interested in one thing: ignoring bad coppers | Marina...

Dick seemed more angered by poor policing on TV than in real life. She’ll be missed by her friends in government, if no one else, says Guardian columnist Marina Hyde

theguardian.com
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Well done to Matthew Wootten for working out how to use a simple idea to create complex conformational behaviour in mixtures of chiral acids, bases, and a metal.
Chemical Science@ChemicalScience9 Feb 2022
Our latest Pick of the Week is on molecular communication💬, by @JonathanClayden from @BristolChem! The @ClaydenGroup demonstrate communication of a conformational response to a spatially remote site 🔥. Read this #ChemSciPicks article for free: 🔗 doi.org/10.1039/D1SC06812A
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Jonathan Clayden retweeted
Angewandte Chemie@angew_chem10 Apr 2021
Triarylmethanes and their Medium-Ring Analogues by Unactivated Truce-Smiles Rearrangement of Benzanilides @ClaydenGroup #openaccess onlinelibrary.wiley.com/doi/…
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Some good news from the ERC arrived in my in-box last week :-) bristol.ac.uk/news/2020/marc…
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With sadness, we are remembering our colleague Dr Stuart Warren who died yesterday. See our story about him here: ow.ly/qPsG50ySSI9
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Alkylation of amino acids has resulted in active pharmaceuticals and building blocks for unnatual peptides. Now a general route for the equivalent arylation is reported in Nature. go.nature.com/2E8yldu
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Jonathan Clayden retweeted
Claire Hansell@HansellThe9 Oct 2018
From @JonathanClayden ‘s group and we totally should have done tagging in the ‘official’ tweet. *shakes fist at Official Nature’s much bigger reach than mine*
Nature Portfolio
@NaturePortfolio9 Oct 2018
Alkylation of amino acids has resulted in active pharmaceuticals and building blocks for unnatual peptides. Now a general route for the equivalent arylation is reported in Nature. go.nature.com/2E8yldu
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A new way to modify amino acids, useful for synthesizing new medicine molecules. “This work allowed us to turn what was a scientific curiosity into (something) really practical" Jonathan Clayden, ERC grantee @BristolUni describes his discovery: bristol.ac.uk/chemistry/news… #EUfunded
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Jonathan Clayden retweeted
Bristol Chemistry@BristolChem4 Oct 2018
Modification of amino acids provides new starting point for development of medical treatments - latest research from @JonathanClayden group published in @NatureNews nature.com/articles/s41586-0…
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Jonathan Clayden retweeted
John Ward@John_W_Ward3 Oct 2018
Extremely proud of our work from @JonathanClayden group on the asymmetric α-arylation of amino acids published in @nature disq.us/t/36wfp4s
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Just out! At last a way to introduce (almost) any aromatic ring to the central C atom of (nearly almost) any amino acid, making either mirror image product at will: Asymmetric α-arylation of amino acids disq.us/t/36wfp4s
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‘Natural substances’ and a natural woman | Brief letters theguardian.com/music/2018/a…

‘Natural substances’ and a natural woman | Brief letters

Brief letters: Chemicals | John Brennan | Aretha Franklin | Pet names

theguardian.com
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The latest method from the Clayden Group: move over Pictet and Spengler...! Consecutive Ring Expansion and Contraction for the Synthesis of 1‐Aryl Tetrahydroisoquinolines and Tetrahydrobenzazepines - Angew Chem Int Ed onlinelibrary.wiley.com/doi/…
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Jonathan Clayden retweeted
John Ward@John_W_Ward2 Mar 2018
Spring has sprung in the @JonathanClayden group! pubs.acs.org/doi/10.1021/jac…

Competing Hydrogen-Bond Polarities in a Dynamic Oligourea Foldamer: A Molecular Spring Torsion...

Abstract. Symmetrical oligourea foldamers were made from meso cyclohexane-1,2-diamine and desymmetrised by incorporating terminal functional groups (carbam

pubs.acs.org
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Collaborations with GSK can inspire all sorts of publications: theguardian.com/music/2017/d…

The romance of the British road, from Putney Bridge to Nempnett Thrubwell | Letters

Letters: Readers respond to Maureen Tilford’s letter asking why American road and place names sound so much more romantic than those in the UK

theguardian.com
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Jonathan Clayden retweeted
Angewandte Chemie@angew_chem16 Oct 2017
Medium-Sized-Ring Analogues of Dibenzodiazepines by a Conformationally Induced Smiles #RingExpansion (Clayden) doi.wiley.com/10.1002/anie.2…
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Our membrane-bound synthetic receptor - just out in @NatureChemistry rdcu.be/pQ7T
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A tendril perversion (that kink in the telephone cable on your desk) trapped inside a helical molecule. dx.doi.org/10.1039/C6SC05474…
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Our new way of making medium (8-12 membered) benzo-fused N heterocycles by a ring-expanding aryl shift. xitter.cf/angew_chem/status/7560…
Angewandte Chemie@angew_chem21 Jul 2016
Medium-ring nitrogen #heterocycles through migratory ring expansion #OrganicSynthesis @jonathanclayden doi.org/f3qqhq

Medium‐Ring Nitrogen Heterocycles through Migratory Ring Expansion of Metalated Ureas

Ringing in ureas: Simple benzo-fused nitrogen heterocycles (indolines, tetrahydroquinolines, and their homologues) undergo migratory ring expansion under basic conditions to generate a range of...

onlinelibrary.wiley.com
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