@JudithSimcox

Associate Professor @UWBiochem studying lipid signaling and regulation | HHMI FHS | opinions are my own and do not reflect those of my employer

 Madison, WI
biochem.wisc.edu/faculty/simcox
Joined November 2018
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Thrilled to have our story on the regulation of lysosomal lipids out in @Cell_Metabolism! The work was led by two outstanding grad students @_JessDavidson and Raghav Jain probing mechanistic control of energy expenditure @HHMINEWS @UWBiochem
Cell Metabolism@Cell_Metabolism14 May 2025
New! Online now: Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV dlvr.it/TKmVgH
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Kivanc Birsoy@KivancBirsoyOct 22
Our new work by @YuyangLiu1996! Short-lived proteins are key regulators of metabolic homeostasis. By investigating their degradation, we identified TXNDC15 as a regulator of ER protein degradation and lipid homeostasis via a catalysis-independent mech. cell.com/cell-chemical-biolo…

Genetic dissection of rapid proteolysis identifies TXNDC15 as a key factor of ERAD and lipid...

ER-associated protein degradation is central to organelle homeostasis, yet many regulatory components remain unknown. Liu et al. exploit the rapid turnover of short-lived proteins to identify TXNDC15...

cell.com
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Long Lab@longlabstanfordOct 22
Our work deorphanizing MCT6 as the missing gut Lac-Phe transporter is out today @CellCellPress: local gut lactate metabolism influences gut-brain crosstalk, and also explains metformin’s effects on body weight. Congratulations to @Shuke_Xiao @alanshtung! cell.com/cell/fulltext/S0092…

MCT6 is an intestinal Lac-Phe exporter required for metformin-associated weight loss

The orphan transporter MCT6 is the route by which the meal- and exercise-associated metabolite Lac-Phe exits intestinal cells and enters the blood. Mice lacking gut MCT6 cannot maintain normal...

cell.com
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Luis Cedeño-Rosario, PhD@luisci22Oct 21
Huge thanks to my co-authors and to the @RutterLab, @gsducker, @JLS_Lab and @dr_ohsopretty labs for making this project possible. 🙏🏾 Read the preprint here: biorxiv.org/content/10.64898… 💪🏾🔥🎉 @UofUBiochem @hhmi_science

Hyperactivation of β-catenin rewires mitochondrial fuel selection in liver cancer cells

Metabolic state is tightly linked to cell fate, and expression of the mitochondrial pyruvate carrier (MPC), which imports pyruvate into mitochondria, is a robust marker of it. The transcriptional...

biorxiv.org
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Rutter Lab
@RutterLabOct 21
We are excited to share this new preprint from our amazing postdoc, @luisci22! Luis discovered that liver cancer cells with overactive beta-catenin switch their mitochondrial fuel usage from glucose to fatty acid oxidation—an unexpected rewiring that challenges conventional Warburg metabolism.
Luis Cedeño-Rosario, PhD@luisci22Oct 21
Excited to share my new preprint from the @RutterLab! What sets a cell’s metabolic state? Using MPC1 as a readout in a CRISPR screen, we found that β-catenin regulates metabolic state in liver cancer cells, driving a switch from carbohydrate to fat oxidation. 🧵
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Guo-Cheng Yuan@gc_yuanOct 12
We are recruiting a postdoc to build ML/AI tools to integrate spatial multiomics to study cancer and neurodegenerative diseases. nature.com/naturecareers/job…

Postdoctoral Fellow in Spatial Biology - New York City, New York (US)

Postdoc in Yuan lab at Mount Sinai, NYC: build ML/AI tools integrating spatial multi-omics to study cancer and neurodegeneration. PhD required.

nature.com
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UW–Madison Biochem@UWBiochemOct 8
Deadline Oct. 15: We are hiring for a professor at any level to join our creative and dynamic community. Candidates in all areas of #biochemistry will be considered, and we are particularly interested in candidates in systems and synthetic biology. jobs.wisc.edu/jobs/assistant…
Poster for job ad. Read further details at jobs.wisc.edu. Job number JR10012489.

ALT Poster for job ad. Read further details at jobs.wisc.edu. Job number JR10012489.

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Please spread the word on hiring in our department. We are searching broadly but particularly interested in Systems and Synthetic Biology. I am chairing this faculty search, please feel free to reach out if you have any questions.
UW–Madison Biochem@UWBiochemOct 8
Deadline Oct. 15: We are hiring for a professor at any level to join our creative and dynamic community. Candidates in all areas of #biochemistry will be considered, and we are particularly interested in candidates in systems and synthetic biology. jobs.wisc.edu/jobs/assistant…
Poster for job ad. Read further details at jobs.wisc.edu. Job number JR10012489.

ALT Poster for job ad. Read further details at jobs.wisc.edu. Job number JR10012489.

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And… I am SO excited to share our first research preprint! In this paper we determined several cryoEM structures to visualize the entire cell-to-cell bridging complex formed by TAM receptor and ligand, bringing into 3D a common graphical depiction. biorxiv.org/content/10.64898…
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ShorterLab@ShorterLabOct 2
A phosphoproteome atlas of human cell lines reveals the landscape of kinase activity: nature.com/articles/s41594-0…

A phosphoproteome atlas of human cell lines reveals the landscape of kinase activity

Nature Structural & Molecular Biology - Koenig et al. present a phosphoproteome atlas of 33 human cell lines covering >200,000 phosphosites, advancing cellular kinase activity scoring...

nature.com
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Long Lab@longlabstanfordSep 30
Lac-Phe is an exercise💪 and metformin💊 inducible blood-borne metabolite that suppresses appetite. How does Lac-Phe get into circulation? New from @Shuke_Xiao: a transporter deorphanization story that links local cellular metabolism to systemic activity: biorxiv.org/content/10.64898…

MCT6 is an intestinal Lac-Phe exporter required for metformin-associated weight loss

Metabolites are increasingly recognized as circulating molecules that regulate physiology, yet the mechanisms that couple intracellular production to organism-wide action remain poorly defined. Using...

biorxiv.org
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Pagliarini Lab@Pagliarini_LabSep 29
Is phosphorylation broadly relevant to mitochondrial protein function? In work led by @AJsmith231, we silenced 10 mito phosphatases, mapped dynamic sites, and revealed functional implications for import, catalysis, and morphology. biorxiv.org/content/10.64898… # Mitochondria #HHMINews

Dynamic protein phosphorylation shapes mitochondrial catalysis, import, and architecture

Phosphorylation is a pervasive mitochondrial protein post-translational modification, yet the extent of its influence over mitochondrial functions remains unclear. To identify dynamic mitochondrial...

biorxiv.org
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Katalin Susztak
@KSusztakSep 24
Our 🆕 paper alert ‼️ Cardiovascular-kidney-metabolic syndrome as a mitochondrial systems disorder our review published in @NatRevNeph @AranyLab @IntMedAbel @pei_liming @JosephABaur nature.com/articles/s41581-0…

Cardiovascular–kidney–metabolic syndrome as a mitochondrial systems disorder

Nature Reviews Nephrology - In this Review, the authors propose a mitochondria-centred, systems-level interpretation of cardiovascular–kidney–metabolic (CKM) syndrome. They highlight...

nature.com
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Leslie Vosshall PhD
@leslievosshallSep 24
Awesome paper on bitter taste in the #mosquito Congrats @BenMatthewsUBC @trevor_sorrells and co-authors! biorxiv.org/content/10.64898…

A Molecular and Cellular Mechanism for Bitter Taste in the mosquito Aedes aegypti

The yellow fever mosquito, Aedes aegypti , is a vector of Zika, Dengue, Chikungunya and yellow fever, disease-causing viruses impacting millions of people annually across the globe. Female mosquitoes...

biorxiv.org
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Lingjun Li Research Group@LiResearchSep 22
Our latest study is out in Nature Protocols 🥳 We present tissue expansion mass spectrometry imaging (TEMI) for high-resolution multiomics mapping of lipids, metabolites, N-glycans, peptides, and proteins 👏 Congrats to all co-authors! 🎉 nature.com/articles/s41596-0…

Tissue expansion mass spectrometry imaging (TEMI) for high-spatial-resolution multiomics molecular...

Nature Protocols - Tissue expansion mass spectrometry imaging enables the mapping of lipids, metabolites, proteins, peptides and N-glycans at high spatial resolution.

nature.com
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I was so lucky to be trained by the late Bob Cooksey as a grad student the McClain lab. Bob was the senior scientist who taught me to respect the HPLC, mentored me through troubleshooting, and led by example. Such an impressive legacy of more than 200 scientific publications.
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Rest easy Bob starksfuneral.com/obituary/r…

Robert ‘Bob' Cooksey

starksfuneral.com
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Cell Biology J-Club@cell_clubSep 17
Version of record. Lipids regulate export of lysosomal enzymes from the endoplasmic reticulum | PNAS pnas.org/doi/10.1073/pnas.26…

Lipids regulate export of lysosomal enzymes from the endoplasmic reticulum | PNAS

Lysosomal enzymes are synthesized in the Endoplasmic Reticulum (ER) and transported to lysosomes to execute their functions. Deficiencies in lysoso...

pnas.org
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Vamsi Mootha@VamsiMoothaSep 16
Our MGH Dept of Molecular Biology is hiring. It’s an exceptional *basic* science dept with a longstanding track record for curiosity driven science, great colleagues / infrastructure and generous support. Assistant Professor nature.com/naturecareers/job…

Assistant Professor - Boston, Massachusetts

Assistant Professor, Depts. of Molecular Biology (Massachusetts General Hospital) and Genetics (Harvard Medical School). Tenure track.

nature.com
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Vamsi Mootha@VamsiMoothaSep 10
Our preprint is now published: In collab. w/ Ruma Banerjee we show how the B12 chaperone MMADHC spends its life in two cellular 'zip codes' dictated by the mitochondrial PMF (similar to PINK1). Co-led by @Sneha_Rath_, Zhu Li. doi.org/10.1073/pnas.2537797…

Mitochondrial depolarization stabilizes the vitamin B12 chaperone MMADHC in the cytosol to increase...

Of the ~1,100 mitochondrial proteins, only a handful like PINK1 and ATFS-1 are known to stabilize and relocalize upon collapse of the proton motive...

pnas.org
Vamsi Mootha@VamsiMoothaJan 2
Excited to share new work in collaboration w/ Ruma Banerjee’s group. Following mitochondrial depolarization, the vitamin B12 chaperone MMADHC is stabilized and boosts B12-dependent MTR activity in the cytosol. Regulation is reminiscent of PINK1, ATFS1. biorxiv.org/content/10.64898…

Mitochondrial depolarization stabilizes the vitamin B12 chaperone MMADHC in the cytosol to increase...

Of the ∼1100 mitochondrial proteins, only a handful like PINK1 and ATFS-1 are known to stabilize and relocalize upon collapse of the proton motive force (PMF) to execute signaling roles. To systema...

biorxiv.org
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Nate Krah
@N8KrahSep 5
🧵 the Krah Lab opens this month and our first preprint is live on bioRxiv! This was a highly collaborative project with the Chaix Lab, @Dorrance_Lab and @RutterLab asking: does the modality of weight loss change how blood and inflammatory cells are made? biorxiv.org/content/10.64898…
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