@JudsonLab

🔬 Studying the effects and distribution of microplastics in the environment and a bit of cycling. #microscopy

 Boston College
bc.edu/content/bc-web/schools/mcas/departments/biology/people/staff/bret-judson.html
Joined February 2020
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263Media
Bret Judson retweeted
Henne_Lab@HenneLabMar 12
I am so excited to co-organize the scientific program for ASBMB 2027 together with Amy Palmer! Please join us in beautiful Boston April 3-6, 2027. Interested in organizing a mini-symposia or workshop for ASBMB? Please submit your proposals here!: asbmb.org/annual-meeting/pro…

Proposals

asbmb.org
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How can you make a zebrafish fin grow into a triangle instead of a fork?? Congratulations to Eric and @nicocump and the whole team! biorxiv.org/content/10.1101/…
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Image: Pak1 removal from the plasma membrane is associated w/ endocytic patch internalization. From @MarcusHarrell12, Liu, @DasLab_Pombe et al. showing that Arp2/3-dependent endocytosis ensures Cdc42 oscillations by removing Pak1-mediated negative feedback hubs.la/Q02GQdZj0
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Happy to share the latest, unexpected story, coming out of my lab: HAM1, a novel mating regulator specific for Cryptococcus neoformans. You can find it at @ASMicrobiology's Microbiology Spectrum here: journals.asm.org/doi/10.1128… For a quick summary, see the 🧵
Proposed model of HAM1 involvement in C. neoformans's biology. Based on our results, we believe that HAM1 acts as a negative regulator of the mating cycle of C. neoformans. Upon activation of the pheromone-response pathway, HAM1 is repressed in a Cpk1-dependent manner. However, under non-mating conditions, HAM1 is induced by unknown signals. When induced, HAM1 works by inhibiting pheromone and pheromone-response genes, or somehow inhibiting hyphal formation directly. During pathogenic conditions, we believe that HAM1 is highly expressed to prevent mating from occurring due to the low-nutrient environment of a mammalian host. The changes we see in the capsule of the ham1 mutant could be a direct function of HAM1 or an indirect result of altered mating signaling (hence, dashed lines).

ALT Proposed model of HAM1 involvement in C. neoformans's biology. Based on our results, we believe that HAM1 acts as a negative regulator of the mating cycle of C. neoformans. Upon activation of the pheromone-response pathway, HAM1 is repressed in a Cpk1-dependent manner. However, under non-mating conditions, HAM1 is induced by unknown signals. When induced, HAM1 works by inhibiting pheromone and pheromone-response genes, or somehow inhibiting hyphal formation directly. During pathogenic conditions, we believe that HAM1 is highly expressed to prevent mating from occurring due to the low-nutrient environment of a mammalian host. The changes we see in the capsule of the ham1 mutant could be a direct function of HAM1 or an indirect result of altered mating signaling (hence, dashed lines).

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giving away free art posters of this project THIS SATURDAY, 10-5 in my lab @NaturalSciences come get one!
NC State Sciences@NCStateSciences25 Apr 2024
.@NCStateBioSci Entomologist @DrAdrianSmith worked with photographer and artist @xavibou_ to turn images of insects in motion into photographic works of art. See more of the photos in the latest edition of @NatGeo magazine. ➡️: ncst.at/ouQu50RnuGH
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Bret Judson retweeted
Henne_Lab@HenneLab22 Feb 2024
Please re-tweet! We're searching for a Drosophila lab technician! Interested in Drosophila as a model to study metabolism & lipid biology? Please DM for details. Ideal position for recently graduated undergraduates interested in research experience prior to grad school.
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My postdoc work is out!🎉 We used snRNAseq in human and NHP striatum to look at the effects of OUD and found elevation of DNA damage markers and sex-specific effects! A huge shoutout to @BadoiPhan, @apfenning, & my incredible PD mentor @wickedneuro! nature.com/articles/s41467-0… – at Cambridge, MA

Single nuclei transcriptomics in human and non-human primate striatum in opioid use disorder

Nature Communications - Dysfunction in dorsal striatum, a brain region important for reward and habits, is linked to opioid use disorder (OUD). Here, authors delineate diverse cell populations in...

nature.com
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I am super excited to share that I’ll be starting my lab at the School of Biological Sciences, Nanyang Technological University (@ntusbs) in February! 🧪 We’ll be delving into the role of organelle contact sites in the endolysosome system. sites.google.com/view/shosuz…

Home

Eukaryotic cells compartmentalize biochemical reactions and cell signaling events in membrane-bound organelles. These organelles actively communicate with each other at the membrane-contact sites...

sites.google.com
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📢 Make space for space biology! GeneLab for High Schools (GL4HS) application for students and teachers will be open from Jan 8-Feb 4! Transform what you know about biology in this four-week program. #STEMeducation #gl4hs #biology #apbiology More info: tinyurl.com/gl4hs2024
GeneLab 4 High Schools (GL4HS) Flyer 2024

ALT GeneLab 4 High Schools (GL4HS) Flyer 2024

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This #FluorescenceFriday we’re highlighting Brainbow in Drosophila, which Ari Dehn, Vicki Losick @BostonCollege and colleagues use to detect cell fusion in flies aged for 40 days. 📖@J_Cell_Sci: journals.biologists.com/jcs/…
Representative immunofluorescence images of 5-day- and 40-day-old dBrainbow flies showing that cell fusion occurs in older flies (bottom panels).

ALT Representative immunofluorescence images of 5-day- and 40-day-old dBrainbow flies showing that cell fusion occurs in older flies (bottom panels).

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Great to see our work mentioned at the @nytimes nytimes.com/2023/09/19/scien…

You May Have This Blobby Animal to Thank for Your Nervous System (Published 2023)

Researchers propose that placozoans, one of the simplest kinds of animals, may contain the blueprint for the neurons of more complex creatures.

nytimes.com
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Bret Judson retweeted
Fromme Lab@Fromme_Lab25 Jul 2023
Very excited to share our latest manuscript! @KaitlynManzer characterized the temporal dynamics of Arf1 inactivation during Golgi maturation by Arf-GAPs, and also showed that the late-Golgi GAP Age2 localizes through a membrane-binding amphipathic helix. tinyurl.com/2yj758v3
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JOB OPENING at DUKE LMCF - new link: academicjobsonline.org/ajo/j… come join us - info & questions: microscopy.duke.edu
Dr. Lisa Cameron@MicroscopyLAC9 Dec 2022
Hey all #microscopists - I have a new position at Duke Univ LMCF for Research Scientist in our core to help with trainings, maintenance and researcher projects esp. those w experience/ interest in optical trap (new equip added to LMCF). Apply here: academicjobsonline.org/ajo/j…
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Some last minute reminders for #midnightmarathonride2023 !
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Katherine Esau was a pioneering #botanist who received the National Medal of Science in 1989 for her contributions to plant biology, and "for providing a special role model for #WomenInScience." Read her memoir: ow.ly/gN0n50NrCVQ #WomensHistoryMonth #NASmember
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👩🏻‍🔬☘️ The #MarchMadness Final Four matchups are set—now send @alfmireles to the #STATMadness Final Four! ✨ ✅ Vote for her @NotreDame research before midnight tonight: statnews.com/feature/stat-ma… – at Notre Dame, IN
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Attn scientists! Could you help spread the word? We are looking for a vacuum circuitboard for our JEOL 100-CX TEM . She ran great for 45 years! But we need a new vacuum board. Maybe there’s one around collecting dust? #electronmicroscopy #labhelp #microscopy #sciencetwitter
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Bret Judson retweeted
Rylie Walsh@RylieWalsh16 Mar 2023
This fellowship has been one of the best decisions I ever made. @JenCWaters, @TalleyJLambert, @annaphoton and @FedeGasparoli are brilliant microscopists and inspiring humans and I’ve learned so much from each of them. If you are an aspiring imaging scientist, you need to apply!
Jennifer Waters@JenCWaters16 Mar 2023
I have a position opening in the Advanced Microscopy Fellowship Program at Harvard Medical School! Applications are due April 6. More information available on the program website below. Please RT. microfellows.hms.harvard.edu
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Senior PhD students in life sciences, please consider applying! Inaugural Weill Institute Emerging Scholars Symposium Career Fair Details | Nature Careers nature.com/naturecareers/eve… #jobs
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Finally, the 2nd most productive collaboration I have had with @alfmireles is out in @Scienceadvances. It started 7 years ago (even longer than our 1st most productive collaboration which is 6-years old!) when she collected patient's fungi-infected catheters. A little 🧵(1/7)
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