@JuhaszLab

We study intracellular degradation systems using Drosophila at HUN-REN BRC Szeged. #EMBOautophagyDiv

 Szeged, Hungary
t.ly/KHQMT
Joined September 2019
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  • Following44
  • Followers96
4Media
Our latest paper explores the Sorting Nexin protein Snx21 to show that it interacts with flotilins to promote endocytosis in Drosophila. @FEBSJournal Congratulations to Tomi, Enikő and the whole team! febs.onlinelibrary.wiley.com…

FEBS Press

In this study, we describe a novel function of the previously uncharacterized Snx21 protein as a specific positive regulator of flotillin-mediated endocytic trafficking. Snx21 is recruited to...

febs.onlinelibrary.wiley.com
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Selective autophagy and its receptors remain an actively evolving field. Our latest review by Jipa et al. discusses receptor-mediated selective autophagy pathways conserved across organisms. 👇 tandfonline.com/doi/full/10.…

Evolutionarily conserved selective autophagy pathways

Selective autophagy is a regulated process that ensures the specific recognition and lysosomal degradation of defined intracellular substrates, including damaged organelles, protein aggregates, and...

tandfonline.com
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Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila. @FEBSnews febs.onlinelibrary.wiley.com…

FEBS Press

Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low-quality granules. The E3...

febs.onlinelibrary.wiley.com
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In this paper, we show how selective autophagy regulates glial immunity after brain injury in Drosophila through Stat92E dependent transcription. Congratulations to the whole team for the first publication of this year! @LSAjournal life-science-alliance.org/co…

Selective autophagy fine-tunes Stat92E activity by degrading Su(var)2-10/PIAS in Drosophila glia

Glial immunity plays a pivotal role in the maintenance of nervous system homeostasis and in responses to stress conditions, including neural injuries. The transcription factor Stat92E is activated...

life-science-alliance.org
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Gábor becomes an EMBO member. 🎉 embo.org/press-releases/outs… brc.hu/en/blog/2025/7/1/gabo…

Outstanding life scientists elected to the EMBO Membership – Press releases – EMBO

Sixty-nine new members join the community of leading life scientists in Europe and beyond

embo.org
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See this link for details of the program: momentummsca.mta.hu Examples of recent papers: 🔹nature.com/articles/s41467-0… 🔹tandfonline.com/doi/full/10.… 🔹sciencedirect.com/science/ar…
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In our latest preprint, we show how autophagy regulates Stat92E dependent transcriptional activity after glial injury in Drosophila. Aron and Virag team up once again! 🙌biorxiv.org/content/10.1101/…

Selective autophagy fine-tunes Stat92E activity by degrading Su(var)2-10/PIAS during glial injury...

Glial immunity plays a pivotal role in the maintenance of nervous system homeostasis and responses to stress conditions, including neural injuries. In Drosophila melanogaster , the transcription...

biorxiv.org
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In @elife: The Rab7-Epg5 and Rab39-ema modules cooperately position autophagosomes for efficient lysosomal fusions doi.org/10.7554/eLife.102663…
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Here we show how lysosomal calcium release via TRPML1 activates its degradative function by facilitating the enrichment and recycling of lysosomal SNARE proteins: jbc.org/article/S0021-9258(2… @jbiolchem Congratulations to Arindam and Hussein!

Lysosomal activity depends on TRPML1-mediated Ca2+ release coupled to incoming vesicle fusions

The lysosomal cation channel TRPML1/MCOLN1 facilitates autophagic degradation during amino acid starvation based on studies involving long-term TRMPL1 modulation. Here we show that lysosomal activa...

jbc.org
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🇮🇸Registration is now open for the 7th Annual NAS conference. This year, it will be held in the beautiful city of Hveragerði, Iceland 🇮🇸 👉Abstracts: June 30th 👉Registration: August 1st To register and more info; nas2024.hi.is 🎉We look forward to seeing you there!
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CORVET-specific subunit levels determine the balance between HOPS/CORVET endosomal tethering complexes. nature.com/articles/s41598-0…
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Gábor Juhász retweeted
Fèlix Campelo@felixmendu3 Apr 2024
This is tomorrow (Thursday)! Looking forward to hearing from @SimonsenAnne and @JuhaszLab on autophagy and membrane trafficking!
Francesca Bottanelli@Fran_Bottanelli3 Apr 2024
#membrane seminars are happening tomorrow with a special session on #autophagy! 5 pm Berlin/Barcelona time zoom link here tomorrow felixcampelo.wixsite.com/mem…
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Collaborative paper by @JuhaszLab in Autophagy: International consensus guidelines for the definition, detection, and interpretation of #autophagy-dependent ferroptosis #celldeath #ferritinophagy #lysosome tandfonline.com/doi/full/10.…

International consensus guidelines for the definition, detection, and interpretation of autophagy...

Macroautophagy/autophagy is a complex degradation process with a dual role in cell death that is influenced by the cell types that are involved and the stressors they are exposed to. Ferroptosis is...

tandfonline.com
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Here we show that the phospholipid PtdIns4P is a critical regulator for autophagosomal recruitment of the SNARE protein Syntaxin 17 towards lysosomal fusion: tandfonline.com/doi/full/10.… Congrats Hajni, Arindam, Asha and team.

PtdIns4P is required for the autophagosomal recruitment of STX17 (syntaxin 17) to promote lysosomal...

The autophagosomal SNARE STX17 (syntaxin 17) promotes lysosomal fusion and degradation, but its autophagosomal recruitment is incompletely understood. Notably, PtdIns4P is generated on autophagosom...

tandfonline.com
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Our Drosophila Snz paper makes it to the latest @MBoCjournal cover🎉🎉molbiolcell.org/doi/suppl/10… Congrats to Tomi, Dalma, Eniko et al. Paper link👇 molbiolcell.org/doi/full/10.…
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Here we show that Drosophila Snx25 homolog Snazarus maintains nephrocyte diaphragm by counteracting Rab11 function. Congrats to Tomi, Dalma and team. @MBoCjournal molbiolcell.org/doi/10.1091/…

Interaction of the sorting nexin 25 homologue Snazarus with Rab11 balances endocytic and secretory...

We report a novel function of the sorting nexin 25 homolog Snazarus in larval garland nephrocytes, the highly endocytic, podocyte-like cells of Drosophila. We propose a model in which Snz negatively...

molbiolcell.org
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Our LC3-associated phagocytosis (LAP) paper in clearance of axon debris is out on @NatureComms Terrific work by Aron and team. Read here: nature.com/articles/s41467-0…

LC3-associated phagocytosis promotes glial degradation of axon debris after injury in Drosophila...

Nature Communications - Glia are housekeepers of the nervous system that eliminate neuronal debris after injury. Here, the authors show that LC3-associated phagocytosis in Drosophila glia promotes...

nature.com
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Our review about crinophagy, a mechanism for secretory granule degradation is out. ——— The role of crinophagy in quality control of the regulated secretory pathway | Journal of Cell Science | The Company of Biologists journals.biologists.com/jcs/…

The role of crinophagy in quality control of the regulated secretory pathway

Summary: Key recent advances in our understanding of crinophagy – the direct fusion of secretory granules with lysosomes – and related degradation pathways are discussed, including potential links to...

journals.biologists.com
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Gábor Juhász retweeted
Fly-EDS@Fly_EDS24 Apr 2023
Calling all European fly researchers! The 2023 European Drosophila Board elections are open! Closing date is May 19th. The candidate statements and voting link are on the EDS web site: europeandrosophilasociety.or… Make your vote count! Results announced @EDRC2023
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Jipa & Juhász @BiologicalRese1 preview work by Wang lab (bit.ly/413O0k6) which shows a surprising antagonism btwn. 2 branches of the unfolded protein response that dictates disease progression in a model of autosomal dominant #RetinitisPigmentosa bit.ly/3KTLuHQ
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