@Kearney_Lab

Head, Molecular Immunology Laboratory, ONJCRI, Melbourne, Australia.

 Melbourne, Australia
Joined July 2016
  • Tweets97
  • Following298
  • Followers400
A/Prof Conor J Kearney retweeted
Cell Reports@CellReports29 Dec 2025
CRISPR screens define unified hallmarks of cancer cell-autonomous immune evasion dlvr.it/TQ3nvC

CRISPR screens define unified hallmarks of cancer cell-autonomous immune evasion

Cancer cell-autonomous immune-evasion programs limit the effectiveness of cancer immunotherapy. Huber et al. highlight recent CRISPR-driven discoveries showing how cancer cells resist cytokines,...

cell.com
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A/Prof Conor J Kearney retweeted
A/Prof Conor J Kearney@Kearney_Lab28 Dec 2025
Excited to share our latest review which identifies unified hallmarks of cancer cell immune evasion @Kearney_Lab @Vervoort_Lab @ONJCRI @WEHI_research sciencedirect.com/science/ar…
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A/Prof Conor J Kearney retweeted
CRISP_SCIENCE
@ScienceCrisp25 Dec 2025
Review "CRISPR screens define unified hallmarks of cancer cell-autonomous immune evasion" Huber A, Djajawi TM, Rivera IS, Vervoort SJ, Kearney CJ. Cell Rep. 2026-01-27. sciencedirect.com/science/ar…
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A TAK1 cytokine toxicity checkpoint controls anti-cancer immunity: Cell Reports cell.com/cell-reports/fullte…

A TAK1 cytokine toxicity checkpoint controls anti-cancer immunity

Djajawi et al. reveal TAK1 as a cancer-intrinsic cytokine toxicity checkpoint that protects tumor cells from TNF and IFNγ. Loss or inhibition of TAK1 promotes cFLIP degradation, RIPK1-caspase-8-med...

cell.com
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A/Prof Conor J Kearney retweeted
Ian Parish@IanParish_AU21 May 2024
We’ve known about tolerant CD8+ T cells for >25 yrs – but what are these cells?! Prematurely exhausted, stalled effectors, or something else? Our latest @ImmunityCP paper takes a deep dive into this question with some unexpected results, including a link to cancer… (1/)
Immunity@ImmunityCP21 May 2024
Online now: The CD8+ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects dlvr.it/T7BsSt

The CD8+ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein...

Steady-state antigen recognition triggers tolerant CD8+ T cell states that restrain autoimmunity and limit anti-cancer immunity. The relationship between tolerant states and other differentiation...

cell.com
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A/Prof Conor J Kearney retweeted
ONJ Cancer Research Institute@ONJCRI3 May 2024
🎉 Let’s celebrate #anticancer champions, Conor @Kearney_Lab and Matthias @lab_ernst for securing a collective $4.3 million in @nhmrc funding! Get ready for a new era in cancer treatment options as the team at ONJCRI unite against cancer. Are you with us?
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A/Prof Conor J Kearney retweeted
ONJ Cancer Research Institute@ONJCRI18 Mar 2024
We celebrated St Patrick's day with a pot of research gold! Dr Conor Kearney and collaborators unveiled ground-breaking findings that significantly contribute to our #Anticancer fight - a finding as thrilling as a jig on a Temple Bar! 🍀 Read more onjcri.org.au/latest-news/ma…
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A/Prof Conor J Kearney retweeted
Ajith Vasanthakumar@ajithvasanthan15 Feb 2024
Replying to @KalliesLab
@KalliesLab and I are excited to share our latest study in @NatImmunol dissecting the heterogeneity and function of VAT Tregs. Huge effort from @Santiago_VaTo and Kevin Man @TheDohertyInst @UniMelbMDHS @ONJCRI @LIMSLTU Thanks to all our collaborators!! nature.com/articles/s41590-0…
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A/Prof Conor J Kearney retweeted
Cell Reports@CellReports26 Feb 2024
PRMT1 acts as a suppressor of MHC-I and anti-tumor immunity dlvr.it/T3HkHw

PRMT1 acts as a suppressor of MHC-I and anti-tumor immunity

PRMT1 negatively regulates STAT1-driven MHC-I expression and can be targeted to enhance the efficacy of cancer immunotherapy.

cell.com
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A/Prof Conor J Kearney retweeted
Ricky Johnstone@JohnstoneRicky26 Feb 2024
Congrats to Coner Kearney, Mario Djajawi, and @PijpersLizzy for this beautiful study. Awesome collaboration between @PeterMacRes and @ONJCRI. cell.com/cell-reports/fullte…

PRMT1 acts as a suppressor of MHC-I and anti-tumor immunity

PRMT1 negatively regulates STAT1-driven MHC-I expression and can be targeted to enhance the efficacy of cancer immunotherapy.

cell.com
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A/Prof Conor J Kearney retweeted
ONJ Cancer Research Institute@ONJCRI15 Dec 2023
🥳 Great news! $1.2M @nhmrc Ideas Grant awarded to CI’s Conor Kearney #ONJCRI, Stephin Vervoort @WEHI_research & associate investigators to identify new immune checkpoint targets in #cancer to improve #immunotherapies Congrats @Kearney_Lab @Vervoort_Lab @latrobe [1/2]
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Two weeks left to apply to join the @Vervoort_Lab at @WEHI_research supported by @SnowMedical Do you want to explore the unknown in the field of gene regulation? Do you love #Genomics #CRISPR #Transcription? Then we are looking for you 🫵 Plz share 📥 wehi.wd3.myworkdayjobs.com/e…
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A/Prof Conor J Kearney retweeted
ONJ Cancer Research Institute@ONJCRI5 Jan 2023
Thanks Austin Medical Research Foundation @AustinMRF1 for #grants to further research into breast cancer and predicting colorectal cancer patient outcomes! bit.ly/3VJZ8zy Well done Camilla Reehorst, @conorkearney88 @drbhupinderpal, Jimmy Chan, Amr Allam, Zhipeng Cao
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A/Prof Conor J Kearney retweeted
FrezzaLab@FrezzaLab16 Dec 2022
ATG9A prevents TNF cytotoxicity by an unconventional lysosomal targeting pathway science.org/doi/10.1126/scie…

ATG9A prevents TNF cytotoxicity by an unconventional lysosomal targeting pathway

ATG9A promotes the LC3-independent lysosomal detoxification of the cytotoxic complex IIa to prevent TNF-induced apoptosis.

science.org
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Over at the tumour immunology session- a fabulous presentation by PhD student, @LizzyPijpers from the @PeterMacCC 🙌 #ASI2022MEL @WEHI_research @ONJCRI @conorkearney88 @Stephintje @rickyjohnstone
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A/Prof Conor J Kearney retweeted
ONJ Cancer Research Institute@ONJCRI28 Sep 2022
A/Prof Erinna Lee @ONJCRI Cell Death and Survival Lab (headed by A/Prof Doug Fairlie) presents on her work to understand the molecular mechanisms underlying cell survival decisions dictated by apoptosis and autophagy #NBS2022 @RMIT @UniMelb @latrobe
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A/Prof Conor J Kearney retweeted
ONJ Cancer Research Institute@ONJCRI28 Sep 2022
More thought provoking presentations from A/Prof Michael Hildebrand, A/Prof Rachel Davey, Dr Kylie Quinn @ONJCRI #NBS2022 today 👏. Top analogy of the day from A/Prof Peter Mount - “Acute Kidney Injury is like a car breaking down” @Unimelb @latrobe @RMIT @TheFlorey @TheFlorey
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A/Prof Conor J Kearney retweeted
ONJ Cancer Research Institute@ONJCRI28 Sep 2022
Head, Molecular Immunology Lab @ONJCRI Dr @conorkearney88 presents at our Inaugural Northern’s Brightest Stars - Student Symposium on drug screening technology. His top tip – don’t be biased in experiments by pre-empting results #NBS2022
@UoM @latrobe @RMIT
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Congrats to my stellar lab member Izzie, + Edwin & @Stephintje, on their latest pub in @cddpress identifying new epigenetic regulators of B cell fate! @WEHI_research @WEHI_Postdocs nature.com/articles/s41418-0…

Epigenetic modulators of B cell fate identified through coupled phenotype-transcriptome analysis

Cell Death & Differentiation - Epigenetic modulators of B cell fate identified through coupled phenotype-transcriptome analysis

nature.com
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Toby Williams @DrTobiasW, a #postdoc in the Wickramasinghe lab @PeterMacRes studies the roles of mRNA export machinery in the protection of genomic integrity and how #mRNA export can protect #Cancer cells against mRNA transcriptional therapies. #CancerResearch
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