Biosynthetic Design of Natural Products et KriesLab et mstdn dot science
Jena, Germany
Joined March 2019
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Who decides product specificity in nonribosomal assembly line synthesis? The answer is important for making new antibiotics through #NRPS engineering. Now out @ACSCatalysis. bit.ly/3yeXuKH Thanks to our collaborators @david_niquille & J. Reinstein @mpi_mr_hd. @LeibnizHKI
Yes, I think you should. The twitter crisis is a unique chance to build a better community for scientists on #Mastodon without ads and attention-hogging algorithms. #twexit
nature.com/articles/d41586-0…
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KriesLab retweeted
Today we celebrate #WorldScienceDay for Peace and Development 🌍🦠💊🔬🧫🧪🧬
So we asked some of our researchers what motivated them to become scientists:
@microverse_exc @LeibnizWGL @TRR_FungiNet @chembiosys_jena
@Buettner_H @mgblango @KriesLab @zcseresn
On bioRxiv: Adenylation multispecificity guided us to find broad evolvability of #nonribosomal surfactin synthetase SrfAC. Provides guidelines which enzyme residues have potential for bioengineering #antibiotics. Congrats Aleksa! @LeibnizHKI @SvenssonCarl bit.ly/3LqOJoD
KriesLab retweeted
Just my yearly reminder: there is a standard format behind (probably) most published papers. I highly recommend all students look at that format: journals.plos.org/ploscompbi… makes writing easier for my students (and myself)
Did you know that an artwork of Beuys once got mopped up by accident? Indiscriminate cleaning up of biosynthetic intermediates can be a loss or a benefit for engineered #NRPS as shown by Farzaneh&Sayan in ACS Chem Bio. @LeibnizHKI @KriesLab @Hertweck_Lab bit.ly/3B779qX
KriesLab retweeted
In our institute, we pursue many different approaches to find new therapeutic agents. One cool way is Biosynthetic Design in @KriesLab and it's probably best we let Hajo Kries explain what that is himself:
KriesLab retweeted
Happy to share the latest synthesis project: Total Synthesis and Functional Evaluation of IORs, Sulfonolipid‐based Inhibitors of Cell Differentiation in Salpingoeca rosetta onlinelibrary.wiley.com/doi/… @ERC_Research @TRR_FungiNet in collaboration @KriesLab @LeibnizHKI @Choano_Lab
KriesLab retweeted
Great collaboration between @Hertweck_Lab, Michael Groll @TU_Muenchen and @KriesLab funded by @chembiosys_jena, @tmwwdg und other sources
Leibniz-HKI researchers from @Hertweck_Lab - in cooperation with @TU_Muenchen - have identified an enzyme that is a promising new therapeutic target to combat dangerous bacterial diseases caused by Burkholderia
@felix_trottmann
leibniz-hki.de/en/press-rele…
KriesLab retweeted
Excellent opportunity for a PhD project between @andrecobb and my lab at King's College London: Using photoredox catalysis to manipulate posttranslational modifications! findaphd.com/phds/project/di…
Congrats Jacob Wurlitzer & Markus Gressler! We recorded substrate profiles in this exciting project on fungal #NRPS. Knowing side-activities helped to develop a biosynthetic strategy for fluorophore-labeled peptides. @LeibnizHKI @ChemicalScience @UniJena doi.org/10.1039/D2SC00860B
KriesLab retweeted
Biosynthesis of strychnine | Nature. Congratulations Benke. And thanks everyone for your help on this one. nature.com/articles/s41586-0…
