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Krusemark Lab

@KrusemarkLab

Lab of Casey Krusemark @ Purdue University

 West Lafayette, IN
krusemarklab.org
Joined April 2016
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  • Followers245
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Don't miss the DEL symposium in Boston August 14-15! Registration opens May 1! #DELsymposium #DELs delsymposium.org

14th International Symposium on DNA-Encoded Chemical Libraries | September 10-11, 2026 | Boston,

Official website of the 2026 DEL symposium

delsymposium.org
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Big thanks to all contributing authors and to co-editors Guansai and Jin! #RSC #delbook #drugdiscovery books.rsc.org/books/edited-v…
DNA-encoded Library Technology for Drug Discovery

DNA-encoded Library Technology for Drug Discovery

DNA-encoded libraries have numerous advantages over traditional screening methods, including easy identification of compounds and the large quantity of com

books.rsc.org
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Here's lab member LW schooling folks on the wonders of cyclic imines! #mannich #targetedcovalentinhibitors #TIDEtalks
Image from Krusemark Lab (@KrusemarkLab)
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I'm attending! #medchem #springACS #DELs
Image from Krusemark Lab (@KrusemarkLab)
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We are hiring! Know anyone who might be interested? Excellent postdoc opportunity to apply DNA-encoded chemical libraries (#DELs) to new areas. krusemarklab.org/wp-content/…
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Happy Lunar New Year from the Krusemark Lab! #labphoto
Image from Krusemark Lab (@KrusemarkLab)
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Nice highlight of BC and AM recent ChemSci paper! Thanks @XChemInc x-chemrx.com/proximity-label…
Proximity Labeling: DEL Selection Without Capturing the Target - X-Chem

Proximity Labeling: DEL Selection Without Capturing the Target - X-Chem

DNA-encoded library (DEL) selections typically use affinity pulldown to enrich compounds that bind targets of interest. While it is highly effective at identifying hits for numerous targets, affinity...

x-chemrx.com
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Celebrating ZA joining the lab! #labouting #irishpub #labphotos
Image from Krusemark Lab (@KrusemarkLab)
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AM paper pre. Improving photodeprotection efficiency through cation stabilization. Nice increases in photolysis quantum yields! #cationstabilization #coumarinPGs #groupmeeting pubs.acs.org/doi/full/10.102…

Strategy for Engineering High Photolysis Efficiency of Photocleavable Protecting Groups through...

Abstract. Photolabile protecting groups (PPGs) enable the precise activation of molecular function with light in many research areas, such as photopharmaco

pubs.acs.org
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Paper pre from YB. Provocative work to increase the diversity DNA-encoding molecules via a mating mechanism! I guess molecular mating is safe for work. #MatingDELs #peptidenucleicacids #groupmeeting nature.com/articles/s41557-0…
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SW paper pre. Covalent reversible ligands from phage that target lysine. Nice to see boron getting some work! #stabilizedimines #phagedisplay #groupmeeting pubs.acs.org/doi/abs/10.1021…
Lysine-Targeted Reversible Covalent Ligand Discovery for Proteins via Phage Display

Lysine-Targeted Reversible Covalent Ligand Discovery for Proteins via Phage Display

Abstract. Binding via reversible covalent bond formation presents a novel and powerful mechanism to enhance the potency of synthetic inhibitors for therape

pubs.acs.org
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YS paper pre. Trio-pharmocophore DELS. Count em, 3! Vital inclusion of linker optimization! Linkerology is so frequently the sticky wicket and deserves more attention! #triopharmocophore #DELlinkers #groupmeeting nature.com/articles/s41467-0…
Trio-pharmacophore DNA-encoded chemical library for simultaneous selection of fragments and linkers

Trio-pharmacophore DNA-encoded chemical library for simultaneous selection of fragments and linkers

Nature Communications - Dual-pharmacophore DNA-Encoded Libraries (DELs) can generate large libraries, but linker optimisation is challenging. Here, the authors report a trio-pharmacophore DEL...

nature.com
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GM paper from AM. Using near IR light to switch on a fluorophore. I generally use switches to turn on the lights. Finally, light gets to do some switching! #diazocoumarin #groupmeeting #turnon pubs.acs.org/doi/abs/10.1021…
A Visible and Near-Infrared Light Activatable Diazocoumarin Probe for Fluorogenic Protein Labeling...

A Visible and Near-Infrared Light Activatable Diazocoumarin Probe for Fluorogenic Protein Labeling...

Abstract. Chemical modification of proteins in living cells permits valuable glimpses into the molecular interactions that underpin dynamic cellular events

pubs.acs.org
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Paper pre from YS shows how to convert headpiece DELs to ssDNA. Oh the versatility! #dsDNAtossDNA #lambdaexo #groupmeeting pubs.acs.org/doi/full/10.102…
Converting Double-Stranded DNA-Encoded Libraries (DELs) to Single-Stranded Libraries for More...

Converting Double-Stranded DNA-Encoded Libraries (DELs) to Single-Stranded Libraries for More...

Abstract. DNA-encoded library (DEL) is an efficient high-throughput screening technology platform in drug discovery and is also gaining momentum in academi

pubs.acs.org
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Congrats to BC and YB on their recent paper on DEL selection of biased GPCR agonists! Big thanks to terrific collaborators Amal and Tao! #DELagonists #CIDselection #JACSau pubs.acs.org/doi/10.1021/jac…
Direct Selection of DNA-Encoded Libraries for Biased Agonists of GPCRs on Live Cells

Direct Selection of DNA-Encoded Libraries for Biased Agonists of GPCRs on Live Cells

Abstract. G protein-coupled receptors (GPCRs) are the largest superfamily of human membrane target proteins for approved drugs. GPCR ligands can have a com

pubs.acs.org
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Front cover for BC's Chem Sci Paper! Artwork by BC himself. pubs.rsc.org/en/content/arti…
Front cover

Front cover

Front cover, Chemical Science, Volume 14, Issue 2, 4 January 2023, Pages 217, https://doi.org/10.1039/D3SC90006A

pubs.rsc.org
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He's on cloud nine presenting his poster to the college! Congrats to all the Jenkins/Knevel and Kienly Award winners! #cloudy #JenkinsKnevel #purduepharm
Image from Krusemark Lab (@KrusemarkLab)
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Thanks Purdue Pharmacy for the monthly publication highlight!
Purdue Pharmacy (@purduepharmacy) profile picturePurdue Pharmacy@purduepharmacy5 Dec 2022
Check out our monthly publication highlights! This month we recogonize Drs. Bo Cai and Casey Krusemark. ow.ly/ha7w50LVgcR
Image from Purdue Pharmacy (@purduepharmacy)
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BC's paper is up on ChemSci! #MyFirstChemSci #LittleEngine #ProximityLabeling pubs.rsc.org/en/content/arti…
Selection methods for proximity-dependent enrichment of ligands from DNA-encoded libraries using...

Selection methods for proximity-dependent enrichment of ligands from DNA-encoded libraries using...

Herein, we report a selection approach to enrich ligands from DNA-encoded libraries (DELs) based on proximity to an enzymatic tag on the target protein. Th

pubs.rsc.org
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He did it! Congrats to Dr. Sun! #phd #biggrin
Image from Krusemark Lab (@KrusemarkLab)
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