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The final version of our work is now online in JACS!
Scalable total synthesis of nonthmicin and ecteinamycin revealed a dual antibacterial and antitoxin profile against Clostridioides difficile.
Many thanks to all our collaborators! pubs.acs.org/jacsat/article/…
Our latest work shows how modern total synthesis can enable therapeutically meaningful discovery, uncovering selective anti-C. difficile activity and toxin-protective effects of structurally complex polyether ionophores. Now available on ChemRxiv: chemrxiv.org/doi/full/10.264…
Chao Li Lab retweeted
Final version of this work has appeared today in @ScienceMagazine : science.org/doi/epdf/10.1126…
Our latest work shows how modern total synthesis can enable therapeutically meaningful discovery, uncovering selective anti-C. difficile activity and toxin-protective effects of structurally complex polyether ionophores. Now available on ChemRxiv: chemrxiv.org/doi/full/10.264…
One step. Two C–C bonds. Three natural product syntheses. Our auto-tandem catalytic cascade for natural product synthesis is out today in JACS!pubs.acs.org/doi/10.1021/jac…
First total synthesis of paulomycin A — now in JACS. Rare sugar. Real synthetic challenge. Now accessible.pubs.acs.org/doi/10.1021/jac…
Chao Li Lab retweeted
Cobalt-Catalyzed Photoelectrochemical Dehydration of Primary Alcohols | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…
Chao Li Lab retweeted
Radical Retrosynthesis of Natural Products Enabled by Iron-based Reductive Olefin Coupling. Published today in @ChemRxiv : chemrxiv.org/engage/chemrxiv…
Our Chem. Soc. Rev. Article!
Radical Retrosynthesis: A Powerful Strategy for Modern Assembly of Terpenoid Natural Products.
Modern radical chemistry—MHAT, RAE, XEC, photoredox, HAT—reshapes retrosynthetic logic for complex terpenoids.
pubs.rsc.org/en/content/arti…
Thrilled to share our progress on the synthesis of highly oxidized DMOA-derived meroterpenoids—now out in JACS:pubs.acs.org/doi/10.1021/jac…! The unexpected reaction we stumbled upon in the final step turned out to be especially fascinating.
#TotalSynthesis of DMOA-Derived Meroterpenoids: Achieving Selectivity in the Synthesis of (+)-Berkeleyacetal D and (+)-Peniciacetal I by Jianpeng Zhang, Xiaotong Luo, Jingfu Zhang, and Chao Li @LabChao in @J_A_C_S pubs.acs.org/doi/10.1021/jac…
Chao Li Lab retweeted
Establishing the Comprehensive Structure-Activity Relationship of the Natural Antibiotic Kibdelomycin/Amycolamicin (Chao Li and co-workers) @LabChao onlinelibrary.wiley.com/doi/…
We're excited to have achieved a structure-activity relationship analysis of the complex natural antibiotics Kibdelomycin/Amycolamicin through total synthesis. We hope this work will contribute to the development of new antibiotic therapies. onlinelibrary.wiley.com/doi/…
Chao Li Lab retweeted
The final version of this study was published today in @Nature : nature.com/articles/s41586-0…
Today we report in @ChemRxiv a scalable solution to the total synthesis (and structural reassignment) of the Portimines (bit.ly/3iJ61DT). In collaboration with @_chrisgparker_ and Luke Lairson the remarkable biological activity of this natural product family was revealed
Chao Li Lab retweeted
Excited to share our latest paper on the total synthesis of Illicium sesquiterpenes. Not only access more targets but synthetically connect distinct molecular architectures of different subfamilies through late-stage skeletal reorganization triggered by Lewis acids or oxidants.
Divergent Total Syntheses of Illicium Sesquiterpenes through Late-Stage Skeletal Reorganization | Journal of the American Chemical Society @CHNSci @TotalSynthesis @TotalSyntheses #Divergent #TotalSynthesis #sesquiterpenes #Rearrangement #LateStage pubs.acs.org/doi/10.1021/jac…
