I am here hope to catch up with everyone

Congratulations @FalachRotem for Michaelson's Excellence Award in Alzheimer's Disease Research! very proud of you & your achievements in developing novel methods for detecting abnormal sleep activities in Alzheimer's. Publication soon stay tuned 🤩 @of_sagol @TAUMedFaculty

The Mind's Eye: A quest from vision to consciousness - symposium honoring Rafi Malach Incredible lineup celebrating the career of an amazing scientist. Join us on December 14-15 at the Weizmann Institute ! @ShaGilDot @GaliaAvidan @kalatwt @ShanyGrossman @HassonLab @MichalRamot

Proud and delighted to deliver the keynote presentation at “Sleep Down Under 2025” Adelaide, organized by the Australasian Sleep Association @asa_nest @SleepOrgANZ #SDU2025 #SleepDownUnder

(6/6) ✨ Take-home: LC neurons are not a single unitary arousal system. LC→PRN brainstem pathway is critical for sound-evoked awakening Thanks to team and colleagues 🙌 led by amazing @NMatosevich , Noa Regev, U. Kimchi, N. Zelinger, @SinaKabaha, @MarmelAm & @NoamGabay

(5/6) What happens if you silence LC synapses? Using an optoGPCR (PdCO), we found that shutting down LC→PRN boosts sigma power and deepens NREM sleep. Silencing both PRN + BF was even more effective.

(4/6) Timing is everything ⏱️ Optogenetic activation showed that sound-evoked awakening depends on which LC neurons are active AND when they fire - synchrony with the sound is key.

(3/6) Here’s the twist: only the LC→PRN pathway shows a fast NE surge when sounds are played during sleep. That rapid signal predicts whether the sound will wake the mouse.

(2/6) Not all LC pathways are the same 👀 We compared LC projections to the basal forebrain (BF) and to the brainstem pontine reticular nucleus (PRN). They turned out to be partially distinct populations.

Had a brilliant time at #SXSWLondon organized by @CNSfund discussing the future of sleep - issues ranging from monitoring health, through unique interventions, recording EEG via earbuds, to disengaging from ruminations falling asleep & lucid dreaming @lustenca @simon_joe50