Researcher broadly examining how DNA and RNA epigenetics dynamically regulate gene expression. All views are my own
Bethesda, MD
Joined January 2019
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Shalini Oberdoerffer retweeted
"The world’s first tRNA platform company"? A debatable claim, with so many startups actively aiming to turn transfer RNAs into drugs: nature.com/articles/s41587-0…
@TevardB @ShapeTx @alltrna @ReCodeTx
@LeslieJWilliams @chrisahern @ArcturusRx @jmcoller @afzelius_lovisa @NatureBiotech
Shalini Oberdoerffer retweeted
From Feb issue cover
#Review from Passmore&Coller detailing Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression
@lapassmore @MRC_LMB @jmcoller
#GeneExpression #mRNAdecay #translation #PolyA
Check it out here: go.nature.com/3iBYqD
Shalini Oberdoerffer retweeted
I wrote this article for my own catharsis. I never expected it to be peer reviewed. When @NEJM accepted it, I experienced my first panic attack. 1/
@WomenInMedicine @WomeninOnc @AMWADoctors @womeninmedchat @WomeninAcademi1
Shalini Oberdoerffer retweeted
After much hard work from @RamamurthiLab our latest exploration of the evolution&biochemistry of P-loop NTPases is out. Here we attempt reconstructing changes that might 've transformed an Era-like translation GTPase into an ATPase structural protein elifesciences.org/articles/6…
Shalini Oberdoerffer retweeted
In the week-long Mendez symposium @fredhutch, fantastic talks today in @HutchBasicSci by @Dany_bioArango (@LabShalini) and @yadirasotof (David Allis lab). Very important science. Clearly presented.
Shalini Oberdoerffer retweeted
We are very sad that @AngelikaAmon, first generation PhD student at the IMP, former IMP board member, and lifelong friend of the house, has lost her battle against cancer. Her contributions to science form a lasting legacy we are grateful for. Our thoughts are with her family.
Shalini Oberdoerffer retweeted
First study on RNA transcriptome and epitranscriptome in SARS-CoV-2. Finds a mysterious signal, potentially an RNA modification, in a purine rich motif: biorxiv.org/content/10.1101/…
Shalini Oberdoerffer retweeted
News: NIH clinical trial of investigational vaccine for COVID-19 begins dlvr.it/RS0PPw
Shalini Oberdoerffer retweeted
Two great groups!
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Shalini Oberdoerffer retweeted
Very interesting: Study from the Leidel lab showing no effect of CHX on ribosome profiling in S. pombe. Our RiboSeq looking at the effect of queuosine tRNA modification on translation was rejected at a "major" journal based on the fact that we used CHX ... now in NAR ...
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Shalini Oberdoerffer retweeted
Fresh bioRxiv preprint: #CRISPR Adenine & Cytosine Base Editors with reduced RNA editing off-targets. #genomeediting #baseediting #offtargets #RNA. Mad props to @RonghaoZhou @becauseBiology @CalebLareau @sarapintogarcia @martinaryee & J. Keith Joung. biorxiv.org/content/10.1101/…
Shalini Oberdoerffer retweeted
A chemical inhibitor of the CRISPR–Cas9 gene-editing tool could allow researchers to switch editing on and off in living cells. #ResearchHighlight nature.com/articles/d41586-0…
Shalini Oberdoerffer retweeted
Whiteley et al. @Nature paper on enzymes making new cyclic dinucleotides (tinyurl.com/yyvxnhre) forces an update to the possible #RNAWorld language list. Image from (tinyurl.com/y38k24cw) shows all possible standard c-di-NMPs; red means strong evidence of bio-relevance.
Shalini Oberdoerffer retweeted
Great summary of single-cell analysis methods: A Systematic Evaluation of Single Cell RNA-Seq Analysis Pipelines on @biorxivpreprint biorxiv.org/content/10.1101/…
Shalini Oberdoerffer retweeted
Cell Press is proud to support #WomenInScience, including the ones in our own office! From all of our colleagues, we wish you a happy International Women and Girls in Science Day!
#WomenInSTEM #STEM @WomenScienceDay
Shalini Oberdoerffer retweeted
Nice work from Lori Passmore's lab provides new insights into endonuclease activation in RNA 3' processing!
Activation of the Endonuclease that Defines mRNA 3′ Ends Requires Incorporation into an 8-Subunit Core Cleavage and Polyadenylation Factor Complex cell.com/molecular-cell/full…
Shalini Oberdoerffer retweeted
Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells
nature.com/articles/s41586-0…
Shalini Oberdoerffer retweeted
Our new @NatureComms paper is out! "Single-molecule sequencing detection of N6-methyladenine (& 5mC) in microbial reference materials" @nanopore base modification detection w/ neural networks on microbial references materials nature.com/articles/s41467-0… w/ @Daniela_Bezdan & @cychiu98
