We are interested in all things cell biology but focused on studying cellular mechanotransduction.
Lund, Sverige
Joined November 2018
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We have migrated to @swaminathanlab.bsky.social
and hope you will join/follow us there for more science related discussions.
Swaminathan Lab retweeted
β1 Integrin-FAK-Piezo1 signalling axis drives in-situ stiffening mediated ECM remodelling and invasion of 3D breast epithelium biorxiv.org/cgi/content/shor… #biorxiv_cellbio
🚨🚨REMINDER: Tenure-track and generously funded faculty position in "BASIC research into regenerative medicine and disease mechanisms" at our Wallenberg Center for Molecular Medicine (@LuWcmm ) at Lund University (@lunduniversity ).
🚨📷Be our colleague @lunduniversity!! @LuWcmm
is recruiting 2 PIs (see ads below (and in thread)-link corrected) in Regenerative medicine. SO happy to see basic research being prioritised . These are Tenure Track positions with generous start-up packages.
lu.varbi.com/en/what:job/job…
🚨📷Be our colleague @lunduniversity!! @LuWcmm
is recruiting 2 PIs (see ads below (and in thread)-link corrected) in Regenerative medicine. SO happy to see basic research being prioritised . These are Tenure Track positions with generous start-up packages.
lu.varbi.com/en/what:job/job…
2nd position in translational research in advanced therapy
lu.varbi.com/en/what:job/job…
Can't wait for Fibronectin, Integrin and Related Molecules (FIRM?) GRC! What a great lineup of speakers - fantastic from @WickstromLab @TanentzapfLab
@WickstromLab & myself are happy to announce the program for the upcoming Fibronectin, Integrin & Related Molecules Gordon Research Conference. This is one of the oldest GRC conferences around (since 1982) & we put together an OUTSTANDING program for y'all. Registration is open.
A beautiful tribute to the memory of Zijie Yan from @aps_unc , Rich Superfine and @UNC community.
unc.edu/discover/carolina-re…
Fantastic thread on multi-cellular rotations by @onenimesa and @EpiMechFC
Collective cell motion has many forms, but rotation is the coolest of them all.
I'm @onenimesa, and in this short🧵, I'll highlight some instances of global tissue rotation like this one from @BauschLab
" Integrins are molecular machines w/ parts that undergo large, ∼100 Å movements; however, we believed that we could not understand this machine and truly appreciate its soul—its animating principle—until we saw it move. "- Li et al. -What a tour de force
cell.com/cell/fulltext/S0092…
so many key points in this study:
1. High affinity extended open binds it ligands slower than its low affinity closed state
2. Force transmitted or tension built across the molecule activates it- making it agnostic to identity of molecules
Exciting preprint from the awesome folks (Mavrakis & Brasselet group) at @InstitutFresnel on new fluorescent reporters that will allow for polarisation measurements (in addition to regular microscopy) of actin dynamics in live cells!This is a big deal!
biorxiv.org/content/10.1101/…
Coupling this incredible toolkit with the amazing microscope built by @TalonChandler Min Guo, Patrick La Rivière, and Hari Shroff et al. can push the limits of what we know about actin organisation in cells, tissues and model organisms.@mattersOfLight
biorxiv.org/content/10.1101/…
I'm on my way!
Aleksi Isomursu @aisomursu from @IvaskaLab will defend his doctoral thesis "Biomechanics of cancer cell motility" on Friday 12th of April at 12:00 in the Tauno Nurmela auditorium @UniTurku . Aleksi's opponent will be Vinay Swaminathan from Lund University.
...Alea iacta est....
Just kidding..All the tools involved in these conversations are really amazing..
Great work! Also- Someone please set up a **taxis tournament- Single cell type , opposing gradients of same relative magnitudes (how and what?-not sure).. Hapto vs Chemo; Duro vs Curvo; Rheo vs Visco etc. -- Any guesses on winners?
🚨 How do cells migrate when exposed to curvature cues? We addressed this question using a minimal model developed by Raj Kumar Sadhu & Nir Gov and various curved systems by @LucianoMarine1, @BLadoux and others @PNASNews 👇🏼
pnas.org/doi/10.1073/pnas.23…
So happy to see this in preprint! Molecular orientation can be a critical property of protein organisation in cells that encodes a wide range of biophysical information that localisation alone can't. To get 3D orientation of molecules in cells in complex environment is exciting!
I’m thrilled to share our preprint: “Three-dimensional spatio-angular fluorescence microscopy with a polarized dual-view inverted selective-plane illumination microscope (pol-diSPIM)”, a new 3D take on fluorescence anisotropy. 🧵1/15
Preprint: ⬇️
biorxiv.org/content/10.1101/…
So happy to see @wesley85979105's toil coming to fruition!
Extracellular matrix dependent regulation of Septin 7 in focal adhesions promotes mechanosensing and response in fibroblasts. biorxiv.org/content/10.1101/…
From @vin_swaminathan @wesley85979105 and colleagues
Swaminathan Lab retweeted
New year, New call for cancer biology papers at nature.com/collections/daadb… . DM us if any questions. @TorilHol @mythreyelab @CommsBio @NaturePortfolio
#TME
Our latest #CallforPapers is on the tumour microenvironment (#TME), and is guest-edited by @TorilHol & @mythreyelab! We're excited about cell/mol mechanisms and signalling components underlying the TME, and how these interactions impact cancer therapy.
nature.com/collections/daadb…
Interested in #mechanobiology? How 'bout adhesions, nucleus & cytoskeleton across cells & tissues?MayB new molecular tools & biosensors or LLPS and PTMs are u'r thing? Catch it all @ Mechanobiology across length scales Minisymposia on Sunday 3:30PM @ASCBiology @EMBO #cellbio2023