Research lab of Dr. Stephen Waggoner. Opinions expressed are Dr. Waggoner's alone and not on behalf of lab staff or employer. @labwaggoner.bsky.social
Cincinnati, OH
Joined August 2018
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Lung neuroendocrine cancer induces immunosuppressive macrophages via serotonin to drive resistance to the T cell engager tarlatamab @Cancer_Cell
cell.com/cancer-cell/fulltex… 🇯🇵
Lifestyle-induced regulatory T cell fragility primes adverse events after immune checkpoint blockade @CellCellPress @OveracreLab @UPMCHillmanCC @ItzDipyama
cell.com/cell/fulltext/S0092…
Very excited to share our latest paper, out today in Cell, led by @ItzDipyaman! This project started out with a curiosity as to how and why irAEs happen. Even more peculiar is that WT mice never develop irAEs…and why was that?
cell.com/cell/fulltext/S0092…
Lifestyle-induced regulatory T cell fragility primes adverse events after immune checkpoint blockade @CellCellPress @OveracreLab @UPMCHillmanCC @ItzDipyama
cell.com/cell/fulltext/S0092…
Intron retention regulates STAT2 function and associates with immunotherapy response in lung cancer @ScienceMagazine @jacksonlab
science.org/doi/10.1126/scie…
Two proteins that permeabilize mitochondria promote cell death through distinct mechanisms @ScienceMagazine @MSKCancerCenter
science.org/doi/10.1126/scie…
science.org/doi/10.1126/scie…
The TCF-1-E-protein axis preserves stem-like Th17 identity and prevents autoimmune pathology @CellReports 🇨🇳
cell.com/cell-reports/fullte…
Review @CellRepMed
CNS targeted AAV gene therapies: Recent advances and clinical insights
cell.com/cell-reports-medici…
Deletion of Ctps1 in T cells prevents GVHD and reduces skin rejection @CellRepMed @Inserm 🇫🇷
cell.com/cell-reports-medici…
Adaptamers, compact RNA switches that use FDA-approved drugs to control gene expression by co-opting endogenous RNA-editing machinery rather than relying on foreign proteins @MolecularCell
cell.com/molecular-cell/full… @prashantgmali @UCSD
Waggoner Lab retweeted
Regulatable in vivo gene expression via adaptamers sciencedirect.com/science/ar…
A multi-omic atlas of human T cell exhaustion reveals broad remodeling of protein turnover & ubiquitin regulation not captured by transcriptomic analysis, w/ RNF166 regulating T cell persistence & function @CellCellPress @sydnyeleighruns @UAMS
cell.com/cell/fulltext/S0092…
Computational reconstruction, screening, and engineering of non-LTR retrotransposons uncovers elements, termed Gene Writers, that enable stable transgene integration in human cells using all-RNA delivery @CellCellPress @TesseraTx
cell.com/cell/fulltext/S0092…
isoUDCA, a female-enriched bile acid produced by a gut bacterial consortium favored by estrogen, promotes hepatic cholesterol handling and bile acid metabolism through SREBP2-STARD4-CYP7B1 signaling, thereby alleviating chronic liver injury @CellCellPress
cell.com/cell/fulltext/S0092…
The pyrin inflammasome senses extracellular ʟ-carnitine through the high-affinity carnitine transporter OCTN2 (SLC22A5) to drive IL-1β-mediated inflammation @CellCellPress @Yale
cell.com/cell/fulltext/S0092…
Accessing invasion-competent Plasmodium vivax merozoites reveals antibody-dependent NK cell activation
science.org/doi/10.1126/scia…
@ScienceAdvances 🇰🇭
BCG vaccination mitigates tau pathology and restores cognitive function in PS19 Alzheimer's mice
science.org/doi/10.1126/scia…
@ScienceAdvances @HopkinsMedicine
Large-scale longitudinal analysis of posttransplant immune reconstitution reveals how T cell–directed immunosuppression shapes transplant outcomes
science.org/doi/10.1126/scit… @ScienceTM @dewolf_susan @MSKCancerCenter @KeanMD @BostonChildrens
Excess IL-18 drives fatal mousepox cytokine storm via NK cell immunodeficiency and nonspecific T-cell hyperactivation @JCI_insight @canna_lab @varghese_jemy @ChildrensPhila
insight.jci.org/articles/vie…
Vaccines targeting the inflammasome protein ASC reduce inflammation and downstream pathology in multiple disease models @JCI_insight @UNM
insight.jci.org/articles/vie…
