Professor of Pharmacology and Cancer Biology at Duke University

Durham, NC
Joined December 2020
Online Now: Unprocessed genomic uracil as a source of DNA replication stress in cancer cells dlvr.it/T69bhR
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Registration deadline is approaching for the conference on "Transcription and Genome maintenance" ! There are slots for selected talks! Register before May6th insb.cnrs.fr/fr/transcriptio…
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Online Now: TERRA and RAD51AP1 promote alternative lengthening of telomeres through an R- to D-loop switch dlvr.it/SbMsLc
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Condensates induced by transcription inhibition localize active chromatin to nucleoli dlvr.it/SW3mNS
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Followed by GRC on Genomic Instability, DNA repair and Human diseases; lined up with exciting speakers!! Organized by @LeeZou8 @MSYHuen @MaintainGenome and Kyungjae Myung!! Pls RT.
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Started the @GordonConf GRS on Mammalian DNA Repair with a beautiful talk from @AgnelSfeir ! Excited for all the science to come!
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We are deeply saddened by the loss of David Livingston, MD. He was a towering figure in cancer research who changed the way research is done and was an inspiring mentor to many. Our hearts go out to his family, friends, and colleagues. dana-farber.org/newsroom/new…
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BREAKING NEWS: The 2021 #NobelPrize in Physiology or Medicine has been awarded jointly to David Julius and Ardem Patapoutian “for their discoveries of receptors for temperature and touch.”
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The final program for the DNA Repair GRC 2021 is posted. Lee Zou and GRC prepared an awesome program and new COVID-19 protocols to stay safe. Thank you to all the participants for their support. Can’t wait to meet in-person again. Register by Oct 3! grc.org/mammalian-dna-repair…
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Online Now: A basal-level activity of ATR links replication fork surveillance and stress response dlvr.it/S6l6sc
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Why are #PARPInhibitors so effective on #BRCA-mutant cancer cells? Dr. Lee Zou (@LeeZou8) and his colleagues found that PARP inhibitors work by creating gaps in tumor cell DNA that persist through multiple cell cycles, ultimately leading to cell death. 🔎 bit.ly/3ACPGUr
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A very nice review by Yasuhara and @LeeZou8 on: Impacts of chromatin dynamics and compartmentalization on DNA repair sciencedirect.com/science/ar…
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Our lab is expanding and we're recruiting postdoctoral fellows to study ubiquitin-dependent control mechanisms of gene regulation at MGH/Harvard Medical Please RT! ohlabs.org/apply
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Glad to share our latest paper on a new role of RNA in homologous recombination. Thanks to members of my team and our collaborators! RNA transcripts stimulate homologous recombination by forming DR-loops | Nature nature.com/articles/s41586-0…
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Please RT: DNA repair peeps! The Gordon Research Conference on Mammalian DNA repair with the associated GRS has been moved to start on October 30th and it will be an in person meeting in Ventura,CA. We promise to have a great line up and already have a star keynote in @LabLegube
Cohesin-mediated loop extrusion at DSB contributes to establish gammaH2AX domain. Our last work is out. Congratulation to our super-extra talented PhD student Coline Arnould!!!👏 nature.com/articles/s41586-0…
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