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Our research focuses on revealing the cellular and molecular mechanisms of neurological diseases. @UniEastFinland @AIV_Institute

Kuopio, Finland
Joined April 2021
Photo by Human Brain Disease Modelling (@LehtonenLab)Photo by Human Brain Disease Modelling (@LehtonenLab)Photo by Human Brain Disease Modelling (@LehtonenLab)Photo by Human Brain Disease Modelling (@LehtonenLab)Photo by Human Brain Disease Modelling (@LehtonenLab)Photo by Human Brain Disease Modelling (@LehtonenLab)Photo by Human Brain Disease Modelling (@LehtonenLab)Photo by Human Brain Disease Modelling (@LehtonenLab)Photo by Human Brain Disease Modelling (@LehtonenLab)Photo by Human Brain Disease Modelling (@LehtonenLab)
To celebrate the holiday season and all we've accomplished this year we had our annual lab outing! 🎄 We played escape games (once again, some of us escaped, and some of us didn't...), then had ourselves a delicious 🍔 dinner! So much fun and great times with lovely colleagues🥂
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Happy holidays to everyone! Soon we'll take a break from the hard work to rest and recharge, ready to tackle new challenges in 2025 💪
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Congratulations to our doctoral researcher Tuuli Sonninen on receiving a grant for using a human cell-based model of the blood-brain barrier to study vascular dysfunction in Parkinson’s disease. #Parkinsons #bloodbrainbarrier
Kuopio University Foundation, Antti and Tyyne Soininen Foundation and Helena Vuorenmies Foundation have awarded the 2024 grants. The awards ceremony was held on 16 December 2024 at Kuopio Campus. Congrats! uef.fi/en/article/kuopio-uni…
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Human Brain Disease Modelling retweeted
Warm congratulations to Sanni! The second paper of her PhD studies is now out, shedding light on pericytes’ role in #Parkinsons disease and providing new insights into inflammation and vascular changes. @AIV_Institute @UEF_DPMM @UEFneuroscience
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It may be dark outside but inside Lehtonen lab is BRIGHT 💡 Valtteri Syvänen received 3-year funding for doctoral research @UEF_DPMM congrats! 🥂🥳 Thank you for funding this interesting project and motivated researcher 🤩💪🏻 @AIV_Institute
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Valtteri already has vast experience in our lab using cutting-edge methods with human cells to make dopaminergic neurons and midbrain organoids. Now he is expanding this by making a gut-brain axis model that also utilizes alpha-synuclein and PD patient microbiota.
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Pericytes are necessary in formation and maintenance of the blood-brain barrier. Our findings support the notion that pericytes play a role in the inflammatory and vascular changes observed in PD - these understudied cells are worth continued research!
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Human Brain Disease Modelling retweeted
Congratulations, @NiskanenJonna! Thank you, @UniEastFinland, @UEF_DPMM, and @AIV_Institute, for all the support! Also, thank you, @LehtonenLab, @LabMalm, @KoistinahoLab, and Kelvin C Luk for your contribution.
My first paper is finally out! Uptake of alpha-synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia. Grateful to the whole team! onlinelibrary.wiley.com/doi/… #microglia #stemcells @LehtonenLab @LehtonenSarka
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This study gives us some interesting hints about what is happening to human microglia in a situation that aims to mimic Parkinson's disease pathophysiology by combining alpha-synuclein and inflammation.
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Celebrating many great milestones of our hard work this week! 🥂 1 published paper (Sanni Peltonen & @NiskanenJonna), 1 accepted paper (@NiskanenJonna), & 1 submitted manuscript (Tuuli Sonninen)! Let's go 🥳💪
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Collaborative paper in nanotoday: sciencedirect.com/science/ar… ; preprint Niskanen et al. (accepted to GLIA): researchsquare.com/article/r…
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