@LiGanLab

Please follow us in Bluesky too! https://xitter.cf/t.co/pbbp33G3QU

 New York
ganlab.org/
Joined July 2019
  • Tweets1.1K
  • Following525
  • Followers4.2K
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Check out this @NatureNeuro piece written by @Yale_INP graduate @suzhou_yang and @YaleNeuro @KavliAtYale Postdoc Fellow @zhenlei_ , highlighting recent works by Gitler, @FrattaLab, and La Spada labs on the impact of TDP-43 pathology on mRNA 3' ends in ALS nature.com/articles/s41593-0…
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🏆🏆🏆 CONGRATULATIONS to the winner of the PBL Assay Science Best Speaker Award Sarah Naguib @naguib_sarah! Title: Elucidating the neuroprotective mechanisms of human microglial replacement therapy in FTD and PD Thank you PBL Assay Science for sponsoring the award
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Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer’s disease: @NeuroCellPress cell.com/neuron/fulltext/S08…
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Elated to share my PhD work, new in @ScienceMagazine science.org/doi/10.1126/scie…👩🏻‍🔬 I was struck by how little we knew about the role of biological sex in the brain, especially in response to sex-biased diseases. In #Alzheimers (AD), 60% of patients are women 🧵

Tlr7 drives sex differences in age- and Alzheimer’s disease–related demyelination

Alzheimer’s disease (AD) and other age-related disorders associated with demyelination exhibit sex differences. In this work, we used single-nuclei transcriptomics to dissect the contributions of sex...

science.org
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Inhibiting an immune signaling protein called TLR7 may help preserve the protective layer surrounding nerve fibers in the brain during both Alzheimer’s disease and ordinary aging, according to preclinical study led by Dr. Li Gan (@LiGanLab). Full story: bit.ly/49bdjFS
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Tlr7 drives sex differences in age- and Alzheimer’s disease–related demyelination | @ScienceMagazine science.org/doi/10.1126/scie…
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Thrilled to share new work from our lab led by ⁦@mitchkim_mw⁩! The results provide new insight to immune privilege and hopefully diagnostic/therapeutic tools || Endogenous self-peptides guard immune privilege of the central nervous system | Nature nature.com/articles/s41586-0…

Endogenous self-peptides guard immune privilege of the central nervous system

Nature - Central nervous system (CNS)-derived regulatory self-peptides are essential for maintaining a continuous dialogue between the CNS and the immune system while balancing overt autoreactivity.

nature.com
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Mitochondrial fatty acid oxidation drives senescence; science.org/doi/10.1126/scia…
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Where to start? Activity-dependent alternative translation initiation generates multifunctional proteoforms in the brain dlvr.it/TFZJqZ
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Gan Lab retweeted
htw@heniek_htw18 Oct 2024
Molecular mechanisms of mitochondrial dynamics we aim to present a valuable framework reflecting current perspectives on how mitochondrial membrane remodelling is regulated. nature.com/articles/s41580-0…
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Our goal for the #TauConsortium is to foster collaboration between scientists to help research primary tauopathies. An example of this collaboration in action is the Consortium members’ contribution to a PET radiotracer trial in healthy adult patients: nature.com/articles/s41467-0…
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Could harnessing the brain’s intrinsic cognitive #Resilience mechanisms lead to treatments before onset of #AlzheimersDisease / #Dementia? Learn More on Oct 25 as you JOIN #MSNseminars & hosts @fkchiang89 & @nicole_bussola when they welcome @WeillCornell’s @SadafAmin24.
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Modeling Parkinson’s disease pathology in human dopaminergic neurons by sequential exposure to α-synuclein fibrils and proinflammatory cytokines @NatureNeuro nature.com/articles/s41593-0…

Modeling Parkinson’s disease pathology in human dopaminergic neurons by sequential exposure to...

Nature Neuroscience - Bayati et al. discovered that sequential treatment of iPSC-derived dopaminergic neurons with α-synuclein fibrils and proinflammatory cytokines leads to the formation of...

nature.com
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Mapping multimodal phenotypes to perturbations in cells and tissue with CRISPRmap go.nature.com/481iCHt
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Members of our #TauConsortium recently contributed to a Nature Portfolio publication which set the foundation for a PET radiotracer trial in healthy adult patients. Learn more about how we support PET imaging through our medical research program: nature.com/articles/s41467-0…
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nature.com/articles/s41590-0… I hope this is a helpful review! Appreciate the opportunity to co-write this review in @NatImmunol with my mentor @FitzgeraldKate. Thanks to all the reviewers' comments which significantly elevated our work and thanks to the unsung artists for their art!
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Our focus issue on RNA biology features reviews that explore the many faces of #RNA, diving into the processes mediating the lifecycle of RNA, the regulatory roles of RNA, the importance of RNA in disease, and the technologies used to study RNA. cell.com/molecular-cell/issu…
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Can we use CRISPR screens to identify genes that drive neural stem cell aging? Super excited to see this work published @Nature! Huge congrats to Tyson @ruetz_tyson, Angie Pogson, @kashiwagi_chloe, and all authors! Great collaboration with @MCBassik! nature.com/articles/s41586-0…

CRISPR–Cas9 screens reveal regulators of ageing in neural stem cells

Nature - CRISPR–Cas9 screens in cultures of young and old neural stem cells (NSCs) and in vivo in old mice identify gene knockouts that can boost old NSC activation and neurogenesis, with...

nature.com
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Gan Lab retweeted
nature
@Nature3 Oct 2024
CRISPR helps brain stem cells regain youth in mice go.nature.com/47V2o2Q
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We identified Widespread transposable element dysregulation in human aging brains with Alzheimer’s disease and validated it by CRISPR from @YinShenLab Thanks @NIHAging @CCLRI @YinShenLab alz-journals.onlinelibrary.w…
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