Recent articles about androgen deprivation therapy (ADT) for prostate cancer patients. See https://teapawt.net/t.co/CEv47XzlDB for info on the ADT Educational Program
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📢 Spots are still available for our upcoming live online class on November 18th at 3PM Pacific Time!
Join us to learn more about Androgen Deprivation Therapy and strategies to manage its side effects.
We hope to see you there!
lifeonadt.com/how-to-registe…
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To learn more about Androgen Deprivation Therapy and how to manage side effects, join an upcoming live online class. Next online classes on: July 15th, August 11th, & September 16th, all at 3 PM Pacific time. We hope to see you there! LifeOnADT.com
As of March 12, 2025, our "updates on the recent literature" will be posted on our website LifeOnAdt.com and not on X.
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New study suggests that ADT use is not associated with kidney disease despite older studies suggesting ADT increases risk of renal dysfunction.
ascopubs.org/doi/abs/10.1200…
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A big UK trial failed to find evidence that “adding metformin to standard [ADT}…increases overall survival” in PCa patients with hormone sensitive metastatic cancer. urotoday.com/conference-high…
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Prophylactic tamoxifen or radiotherapy reduce significantly the incidence of gynecomastia and breast pain caused by the older anti-androgens bicalutimide. They may also help prevent breast symptoms from newer anti-androgens. (2/2) sciencedirect.com/science/ar…
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The problem—According to a review of 18 studies comprised of >5000 PCa patients overall, ARPI monotherapy increases gynecomastia and breast pain compared with ADT alone. However, ARPI & ADT doesn’t lead to yet greater breast symptoms. (1/2)
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But selection bias is likely at play here; i.e., patients with a previous history of MACE may be directed to Firmagon or Orgovyx because of that risk. But the risk still remains. (Part 6/6) pubmed.ncbi.nlm.nih.gov/3937…
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MACE risk that the LHRH agonist (like Eligard and Zoladex). But selection bias is likely at play here; i.e., patients with a previous history of MACE may be directed to Firmagon or Orgovyx because of that risk. But the risk still remains. (Part 5/6)
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3) having mets when starting ADT, 4) a previous history of MACE, and 4) treatment with an LHRH antagonist vs. an LHRH agonist. The last one is a surprise since LHRH antagonists (like Firmagon and Orgovyx) are supposed to have less ... (Part 4/6)
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Findings: The risk of a major adverse cardiovascular event (MACE) after starting ADT increased consistently over the following four years (by ∼5% per year). The most significant risk factors for MACE included: 1) older age, 2) being treat in an oncology vs. urology setting(3/6)
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The data were collected between 1991 and 2020, and are stored in the Clarvate Real World Evidence repository (clarivate.com/). (Part 2/6)
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What is the risk of a serious cardiovascular event, like a heart attack or stroke, after starting ADT? An analysis of real world data from >40K PCa patients in the USA takes a deep dive into this topic. (Part 1/6)
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Written by and for the MDs, but a very readable and comprehensive review on how to stay healthy on ADT. Its recommendations match to a “T” the recommendations in the ADT class and book (see: LifeOnAdt.com). pubmed.ncbi.nlm.nih.gov/3970…
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A very rigorous review of the biochemical processes that account for how ADT can increase the risk of a variety of cardiovascular diseases. pmc.ncbi.nlm.nih.gov/article…
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A small study (48 PCa patients from Asia, mean age 69) found no evidence of cognitive decline from a year of ADT, but acknowledged that “the debate is still open” regarding the impact of ADT on cognition. pubmed.ncbi.nlm.nih.gov/3361…
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Just an abstract, but it suggests that ADT can lead to ~11% increase in autoimmune diseases, such as rheumatoid arthritis, which may present as joint pain and stiffness (especially in the early morning and if you have not been exercising). pmc.ncbi.nlm.nih.gov/article…
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Big review on managing ADT side effects. Endorses exercise and also Cognitive Behavioral Therapy for psychological distress. Discusses alternative and additional therapies for advanced PCa, but discussion on transdermal estradiol is not up to date. ascopubs.org/doi/10.1200/EDB…
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Based on data from > 11K high-risk PCa patients undergoing ADT in Hong Kong, statins but not metformin reduced cardiovascular risks and improved overall. hub.hku.hk/handle/10722/3520…
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Darolutamide + ADT in patients with metastatic, but hormone sensitive PCa, statistically improved radiographic progress free survival compared to ADT + placebo. Less fatigue (!) for the men on the treatment versus placebo arm. ascopubs.org/doi/10.1200/JCO…
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