Principal Investigator, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. , RNA structure, riboswitch, ribozyme, aptamer.
SYSU, Guangzhou , China
Joined May 2012
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Excited to share our new preprint: Structural assemblies for an RNA world.
We show that short RNAs can self-assemble into protein-like architectures, including closed cages, finite oligomers, and filaments.
biorxiv.org/content/10.64898…
The Dual-Ribozyme
RNA Ladder and RNA-Calibrated ssDNA
Marker System for Inexpensive RNA Size Standards pubs.acs.org/acsodf/article/…
HDV-like ribozymes use a directly coordinated metal ion as a Lewis acid to activate nucleophilic attack, together with cytosine-mediated general acid catalysis—bridging small ribozymes and metalloribozymes. @lilley_mj rdcu.be/Fte8Y16m4nUa
Introns encode a vast class of Kink-loop RNAs that autoregulate pre-mRNA splicing
biorxiv.org/content/10.64898…
Lin Huang 黄林 retweeted
Cryo-EM structure and assembly mechanism of the Hm kt7-57 RNA filament. A 57-nt RNA motif assembles into an RNA-only filament, as determined by cryo-EM to ~2.7 Å resolution.
Lin Huang 黄林 retweeted
Excited to share our new preprint: Structural assemblies for an RNA world.
We show that short RNAs can self-assemble into protein-like architectures, including closed cages, finite oligomers, and filaments.
biorxiv.org/content/10.64898…
RNA can build cages — and now we also see how RNA can form filaments.
In our study, a 57-nt RNA motif assembles into an RNA-only filament, resolved by cryo-EM at ~2.7 Å resolution.
For decades, the RNA world field has focused on showing that RNA can replicate, catalyze reactions, and act as an enzyme.
But to build something cell-like, chemistry is not enough.
You also need organization, packaging, scaffolding, and compartmentalization.
A viral capsid in symmetry, a clathrin-like cage in appearance — but made entirely of RNA.
Our work reveals the first natural RNA-only T=1 icosahedral 60-mer.
The manA family (RF01745, identified by @RonBreaker lab) forms discrete closed oligomers, including an unexpected 60-
subunit icosahedral-like cage.
Site-specific ribozyme-mediated alkylation of DNA substrates academic.oup.com/nar/article…
PROTEINS: Structure, Function, and Bioinformatics | Protein Science Journal | Wiley Online Journal onlinelibrary.wiley.com/doi/…
Ribocentre-aptamer: an integrative, structure-focused database for RNA aptamers academic.oup.com/nar/article…
Structural Basis of DNA Aptamer A58 Targeting the N-terminal Domain of Sarbecoviruses Nucleocapsid Protein - Journal of Biological Chemistry jbc.org/article/S0021-9258%2…
Unlocking the potential of diarylmethane dyes for living systems: Chem cell.com/chem/fulltext/S2451…
Lin Huang 黄林 retweeted
We are delighted to announce our next RNA Society Member Spotlight!
rnasociety.org/dr--lin-huang
Dr. Lin Huang leads a research group at Sun Yat-Sen Memorial Hospital and Sun Yat-Sen University in China.
Ribocentre-aptamer: an integrative, structure-focused database for RNA aptamers academic.oup.com/nar/article…