Assistant Professor at @bengurionu, structural immunologist & cell biologist | Instructor at Harvard Medical School/Boston Children's Hospital |

Joined January 2020
Thrilled to share our exciting paper on #NINJ1 published in @CellCellPress. NINJ1 acts as "🍪cutter" by cutting and releasing membrane disks leading to lytic cell death. doi.org/10.1016/j.cell.2024.… Congrats to the amazing team-@WuLabHarvard @BobbyHollings @JazlynBorges @LabSteinberg
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Liron David retweeted
It is importent to remember that science will not stop.
"our department is standing by our colleagues in Soroka hospital. we carry on doing science for the benefit of hunan kind in Israel and abroad" - Raz Zarivach, Department Chair (until August)
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Inflammasomopathies: mechanisms and disease signatures dlvr.it/TKHhvq #immunology
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President @Isaac_Herzog tonight addressed a special event honoring the work of the Zuckerman @Stem_Program Leadership Program: “Investing in and advancing academic excellence is not just about knowledge—it is about securing our future, driving economic growth, and ensuring that Israel remains a global leader in discovery and progress. I salute the remarkable Israeli academia. I know how difficult this time has been for faculty, students and academia at large. I know how much you have had to lean on your core qualities of integrity, and commitment to your professional and moral truths in an often unsupportive and even hostile climate. I salute all of you for your commitment to defending the principles at the root of our Israeli society. At these very moments our brothers remain buried alive in the terror tunnels of Gaza, in a shameful crime against humanity. Let us all continue to cry out for them, for their immediate return home.”
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Amazing mentor&lab. Doing exciting science!
We are recruiting! Help us spread the word
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I am truly honored to be awarded with this prestigious award in honor of Dr. Neufeld, together with Dr. Andrew Snow. Many thanks to @usisraelbsf
Congrats to BSF's 2024 Neufeld awardees for their exceptional contributions to #healthscience research: 🏆Dr. @LironDavid2 @bengurionu & Dr. Andrew Snow @USUhealthsci 🏆Prof. Tamar Harel @Hadassah & Dr. @WanheeYoon @OMRF 🔗See all awardees & abstracts: bit.ly/BSF-NeufeldAward
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BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
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Amazing structure and beautiful work! Congrats to all the team 🎉
First tweet in 9 month: proud of our preprint on structure / function of Loki ESCRTs. Team effort of our lab, @SachseGroup, and Bernheim lab.
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Liron David retweeted
Published in Cell: #NINJ1 mediates plasma membrane rupture by cutting and releasing membrane disks. #MINFLUX imaging was used to confirm ring formation of endogenous NINJ1. cell.com/cell/abstract/S0092… Great collaborative project from @WuLabHarvard @LironDavid2 @BobbyHollings @LabSteinberg @JazlynBorges! #pyroptosis
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Super excited to share our story published on GSDMD palmitoylation in Nature @Nature. Congrats to all the GSDMD team!
Exited to share our new paper by Gang Du @ , Liam @L_Heals, Liron David @LironDavid2 and others on GSDMD palmitoylation. “ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D” in Nature nature.com/articles/s41586-0…. Even full-length GSDMD can form pores!
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Happy to share our story on NINJ1, NINJ2 and plasma membrane rupture. The NINJ1 part has a similar structure but different perspective on the mechanism compared to what was published two weeks ago by the @HillerLab @Nature Stay tuned for a similar story from the @WuLabHarvard .
How NINJ1 mediates plasma membrane rupture and why NINJ2 cannot biorxiv.org/cgi/content/shor… #bioRxiv
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So happy to share our #NINJ1 pre-print on Biorxiv reveling NINJ1 rings acting as cookie cutters to mediate plasma membrane rupture. Congrats to all authors @BobbyHollings @LabSteinberg @JazlynBorges
We are excited to share NINJ1 structure and mechanism on BioRxiv that suggest NINJ1 dissolves membranes as a "Ninja" cookie cutter to complete lytic cell death. biorxiv.org/content/10.1101/… by Liron David and Bobby Hollingdworth @LironDavid2 @BobbyHollings
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Another fun collaboration with @YOpatowsky team! #CryoEM Structure of a duplex of SARM1 octamers, an additional auto-inhibition mechanism that prevents pre-mature axon degeneration. @bengurionu @BarIlanU link.springer.com/article/10…
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Super excited to see our cool story on Piezo channels just published @PNASNews Congrats to @WuLabHarvard, @Loreo12 and all the team. A wonderful start for 2023! Happy Holidays!
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An exciting story and a wonderful collaboration! So happy to see it online @CD_AACR! Many thanks and congrats to @WuLabHarvard @LabMelnick @min_xia4 and all the team!
Now online in @CD_AACR: BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for #DLBCL by Min Xia, @LironDavid2 @WuLabHarvard @LabMelnick and colleagues @WeillCornell @BostonChildrens @harvardmed #lymphoma aacrjournals.org/cancerdisco…
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I am very excited to share our preprint titled “Piezo mechanosensory channels regulate centrosome integrity” reveling a new intracellular role for Piezo channels. biorxiv.org/content/10.1101/… 🧵👇
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Also, I would like to thank @LlopisMontero and her team at MicRoN imaging core for training & microscope usage and @iaincheeseman and @ardemp for discussing our manuscript and offering valuable suggestions.
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And let me end this 🧵with a positive note, it’s challenging to publish a novel story in a new field, but if the science is exciting, you should keep going and don’t give up!
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