@LogesK

Molecular cell biologist, studying how proteins are maintained in cells. Now @mrcppu, previously @unimelb @NTU_LKCmedicine @UniofOxford. 🇲🇾🌈👨🏾‍🔬🌏

 Dundee, Scotland
Joined December 2011
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  • Following1.3K
  • Followers390
7Media
Our preprint has now been peer-reviewed and published! We described a role for kinase CK2 and phosphatase CTDNEP1 in regulating protein turnover of SUN2, an inner nuclear membrane protein. Exciting new research avenues for nuclear envelopathies. doi.org/10.7554/eLife.81573

Regulated degradation of the inner nuclear membrane protein SUN2 maintains nuclear envelope...

Biochemical and genetic approaches revealed a posttranslational mechanism controlling the abundance of SUN2, a critical nuclear envelope protein.

elifesciences.org
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Really exciting study! We also didn’t find any membrane protein components for extraction of the nuclear envelope protein SUN2 (ubiquitylated by SCF E3). We discussed that this could be due to redundancy or that pulling force by p97 alone is sufficient. elifesciences.org/articles/8…

Regulated degradation of the inner nuclear membrane protein SUN2 maintains nuclear envelope...

Biochemical and genetic approaches revealed a posttranslational mechanism controlling the abundance of SUN2, a critical nuclear envelope protein.

elifesciences.org
James Olzmann@OlzmannLab1 Dec 2025
1/ New preprint out! We show that PROTAC-induced ubiquitination can bypass canonical ERAD to degrade ER membrane proteins. Wonderful collaboration w/ @DanNomura and huge credit to grad student superstar Sydney Tomlinson! biorxiv.org/content/10.1101/…

Induced ubiquitination bypasses canonical ERAD to drive ER protein degradation

Heterobifunctional proteolysis-targeting chimeras (PROTACs) have emerged as a powerful strategy to degrade disease-relevant proteins, enabling targeting of previously “undruggable” proteins. Current...

biorxiv.org
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The EF-hand domain of MINDY3 is a Ubiquitin and RAD23 UBL-binding domain biorxiv.org/content/10.1101/… #biorxiv_biochem

The EF-hand domain of MINDY3 is a Ubiquitin and RAD23 UBL-binding domain

The MINDY family of deubiquitinases (DUBs) are exemplified by their preference for cleaving K48-linked polyubiquitin. MINDY3 is architecturally distinct from other MINDY DUBs as its catalytic domain...

biorxiv.org
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Branched ubiquitin chains significantly expand the ubiquitin system's signalling capacity. In this #BiochemSocTrans review, McFarland et al. discuss the emerging tools and methods for studying the roles of branched chains in diverse cellular processes.doi.org/10.1042/bst20253015
Detecting branched ubiquitin chain in cells.

ALT Detecting branched ubiquitin chain in cells.

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jobRxiv
@jobRxiv29 Oct 2024
Postdoc in Biochemistry and Cell Biology of SUMOylation and Nucleosome @MSuskiewicz Postdoctoral Position in Biochemistry and Cell Biology of SUMOylation and Nucleosome jobrxiv.org/job/centre-de-bi… #biochemistry #chromatin_biology #nucleosome #structural_... jobrxiv.org/job/centre-de-bi…

Postdoc in Biochemistry and Cell Biology of SUMOylation and Nucleosome

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobrxiv.org
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Our team in Orléans (France) is looking for a new postdoc, to work closely with a research associate, Ibtissam Talhaoui, on a project focused on potential SUMO E3 ligases targeting the nucleosome. The details here: emploi.cnrs.fr/Offres/CDD/UP…
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Busy at work. *sigh* I need a holiday. #EMBOubiquitin2024 #hardtimes #difficultworklife #cavtat #dundee #ubiquitin #scientist @dpriesm @RaRodea16 @gallant_kai
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Rachel O Dea@RaRodea1629 Aug 2024
Delighted to say I have been awarded a MSCA/UKRI funded postdoctoral fellowship to investigate UFMylation at specific sites with @YKulathu . Looking forward to having a new favourite UBL. @MSCActions @UKRI_News @mrcppu
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We are hiring! Two structural biology/biochemistry postdoc positions are available in our lab - come and join a lively Team in the thriving city of Oxford! Deadline 4th October 2024. Further details are here: my.corehr.com/pls/uoxrecruit…
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Martin Smith@martinrsmith25 Jul 2024
UK expensive visas - latest evidence: - Cancer Research UK is expecting to spend £700k on visa costs each year - the equivalent cost of 17 new CRUK PhD students - Cambridge cancer institute being outcompeted for specialists by institutes in Germany, due to costs
Cancer Research UK Policy
@CRUK_Policy25 Jul 2024
Today we are publishing evidence from our Institutes to show the impact of changes to the UK immigration system on cancer research. We call on the new UK Government to reduce costs and review the system so it works for research - to meet their ambitions for health and growth.

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Today we are publishing evidence from our Institutes to show the impact of changes to the UK immigration system on cancer research. We call on the new UK Government to reduce costs and review the system so it works for research - to meet their ambitions for health and growth.

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Hofmann_Lab@LabHofmann25 Jul 2024
After a long time in the making, our study on bacterial clippases is finally available as a preprint biorxiv.org/content/10.1101/… These are really fascinating enzymes, for which there will be a ton of applications in studying the #ubiquitin system

A family of bacterial Josephin-like deubiquitinases with an unusual cleavage mode

Many intracellular bacteria secrete deubiquitinase (DUB) effectors into eukaryotic host cells to keep the bacterial surface or the enclosing vesicle membrane free of ubiquitin marks. Here, we...

biorxiv.org
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Malte Gersch@MalteGersch8 Jul 2024
For all ubiquitin, deubiquitinase and chemical biology aficionados: Here's a preprint from the lab introducing 2 new active DUBs in humans & a unique type of DUB activity one would miss with the widely used panels of free ubiquitin chains. t.ly/GnRVv Thread👇(1/10)
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Yogesh Kulathu@YKulathu8 Jul 2024
Branched #ubiquitin has important roles in cell signaling but are very challenging to study due to complexity & lack of tools. We tackle this challenge in our latest study @NatureSMB developing a toolkit enabling discovery of molecular players and pathways rdcu.be/dM5nn
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How do you stay creative? Medicine laureate Elizabeth Blackburn tells us how she copes and recommends that we all try out a "Swedish fika". Watch the full conversation here: bit.ly/3osp5UZ #CareerAdvice #NobelPrize
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Mahima Swamy@MahimaSwamy9 Jun 2024
Pls RT: We are recruiting a postdoc to study potential new therapeutic targets for #Coeliac disease, at the interface of clinical and basic research- for 3 years starting Sept 2024 #proteomics #Tcells #newjob @UoDLifeSciences @mrcppu t.ly/UuNJ_
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Adrian Liston@LabListon31 May 2024
*whispers* could also be useful for early career scientists wondering how to prepare for an interview🤫
Adrian Liston@LabListon31 May 2024
Are you a PI running job interviews? Want some insights into what questions to ask to find the right candidate? #ImmunologyFutures crowd-sourced the problem, read now at @ImmunolCellBiol! onlinelibrary.wiley.com/doi/…

Immunology & Cell Biology | ASI Journal | Wiley Online Library

Asking the right questions during a job interview helps you find the best person for your team. Here we crowd-sourced the #ImmunologyFutures community for their go-to job interview questions, to...

onlinelibrary.wiley.com
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MRC PPU@mrcppu30 May 2024
Join us! Postdoctoral Research Assistant position available in Sapkota lab ppu.mrc.ac.uk/careers/recrui… @gpsapkota @sapkota_mrcppu
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