Daily news and insights on research, investments and technologies that extend life and improve the quality of that extended life. #Longevity

London
Joined December 2018
Zealand Pharma and Generate Biomedicines will design multispecific proteins for metabolic disease, in a deal with nearly $1.2b in milestones. vist.ly/5pmu2 #longevity #ZealandPharma #GenerateBiomedicines #metabolicdisease #biotech
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Berlin keynote details Eos SENOLYTIX’s pre-clinical results with mitochondrial-targeted geropeptide on healthspan and lifespan. vist.ly/5pmq2 #longevity #geroscience #EosSENOLYTIX #healthspan #lifespan
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What if how well we function matters as much as what’s been diagnosed? Dr John Beard explains why intrinsic capacity could change how we think about aging and care. #longevity #geroscience #intrinsiccapacity
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As pharma shops for de-risked science, venture money is moving later and concentrating in fewer, bigger bets – our report tracks the shift. vist.ly/5pi6t #longevity #geroscience #pharma #venturecapital #biotech
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Avaí Bio and Austrianova began work with Ospedale San Raffaele on protecting lab-grown insulin cells from the immune system. vist.ly/5phkd #longevity #geroscience #AvaíBio #Austrianova #insulin
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Nature Biotechnology paper offers a better way to judge models that predict gene effects. Shift plans to use it to hunt for aging targets. vist.ly/5ph3v #longevity #geroscience #NatureBiotechnology #geneeffects #aging
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Insilico Medicine nominates ISM9546, an oral VAV1 degrader designed with generative AI, as a preclinical candidate for autoimmune disease. vist.ly/5pghr #longevity #geroscience #InsilicoMedicine #ISM9546 #autoimmunedisease
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KAUST and Oxford researchers used a transistor-based sensor to read three forms of alpha-synuclein, reaching 90.9% accuracy in a small study. vist.ly/5pgbw #longevity #geroscience #KAUST #Oxford #alphasynuclein
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Rona Therapeutics grants Roche worldwide rights to an ALK7-silencing candidate, with up to $1.06b in further milestones on the table. vist.ly/5pg62 #longevity #RonaTherapeutics #Roche #ALK7 #biotech
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Intrinsic capacity isn’t simply fitness, independence or being disease-free. It spans cognition, locomotion, psychological and sensory capacity, and vitality, but there’s no universally accepted composite score yet. #longevity #geroscience #intrinsiccapacity
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An up to $28.3 million ARPA-H award aims to stretch Bexorg’s human brain platform from 24 hours to two weeks. vist.ly/5pcav #longevity #geroscience #ARPAH #Bexorg #brainresearch
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German biotech MODAG won for pairing a CE-marked diagnostic with a drug candidate that targets the same protein. vist.ly/5pbv5 #longevity #geroscience #MODAG #biotech #diagnostics
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Adjusting for how advanced patients’ disease was at the start lifts the Phase 2 result. The method was added after the trial began. vist.ly/5pbbj #longevity #geroscience #Phase2 #clinicaltrial #clinicalresearch
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Cala Health’s kIQ Plus now offers three stimulation modes and a calibration before each use, and it’s available across the US. vist.ly/5pb5h #longevity #CalaHealth #kIQPlus #stimulation #digitalhealth
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Buck Institute’s Eric Verdin joins clinic leaders to tackle the ‘luxury diagnostic’ trap and the push for standardized care. vist.ly/5pax4 #longevity #geroscience #BuckInstitute #EricVerdin #standardizedcare
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BodySpec’s new storefront targets muscle loss from GLP-1 weight loss drugs, with scans said to take about 12 minutes. vist.ly/5p8bg #longevity #bodyspec #muscleloss #glp1 #weightloss
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VectorY is growing PIONEER-ALS from 12 to 36 participants to test VTx-002, an antibody therapy aimed at the protein TDP-43. vist.ly/5p7v2 #longevity #geroscience #vectory #pioneerals #vtx002
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A quick digital memory test and a lab assay for brain disease are teaming up to flag neurodegeneration earlier. vist.ly/5p7h3 #longevity #geroscience #memory #braindisease #neurodegeneration
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A Censuswide survey commissioned by PortionIQ finds confidence is lower among longer-term users, though it’s a snapshot from one brand. vist.ly/5p6x7 #longevity #censuswide #portioniq #survey #confidence
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Forget the diagnosis count. The researcher who helped the WHO reframe aging says function, not disease, is the better yardstick. vist.ly/5p6hf #longevity #geroscience #aging #function #disease
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