Ryan White (@LordDNA) header
Ryan White (@LordDNA) profile picture

Ryan White

@LordDNA

👨🏻‍🔬 scientist 🧬 mechanic 🩸 enthusiast ⛷ junkie ☕️ addict. NYC based. 🏳️‍🌈

 New York, NY
Joined March 2011
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  • Following229
  • Followers141
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Photo by Ryan White (@LordDNA)Photo by Ryan White (@LordDNA)Photo by Ryan White (@LordDNA)Photo by Ryan White (@LordDNA)Photo by Ryan White (@LordDNA)Photo by Ryan White (@LordDNA)Photo by Ryan White (@LordDNA)Photo by Ryan White (@LordDNA)Photo by Ryan White (@LordDNA)Photo by Ryan White (@LordDNA)
What does pseudouridine (ψ) actually do to protein production? It’s been studied for years — but its impact on translation has remained surprisingly unclear. We were excited to tackle this directly in our latest NAR paper: tinyurl.com/psitranslation
Image from Sara Rouhanifard (@SRouhanifard)
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Years in the making: a detailed aging gene signature in mice and rats. >30 tissues, high Ns, multi-time points throughout the lifespan. >5000 samples in total. The data is accessible, so you check to see if your favorite gene is age-regulated. science.org/doi/10.1126/scia…
Multitissue, multi–time point transcriptomic atlas of aging in mice and rats

Multitissue, multi–time point transcriptomic atlas of aging in mice and rats

Gene expression changes in multiple tissues throughout the life of mice and rats, suggesting mechanisms for age-related diseases.

science.org
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Latest paper from our group: A Cellular and Transcriptomic Atlas of the Aged Mouse Hematopoietic System onlinelibrary.wiley.com/doi/…
A Cellular and Transcriptomic Atlas of the Aged Mouse Hematopoietic System

A Cellular and Transcriptomic Atlas of the Aged Mouse Hematopoietic System

Transcriptomic and cellular atlas of peripheral blood mononuclear cells (PBMCs) and stem and progenitor cells of the hematopoietic compartment (HSPCs) of aged C57Bl/6J mice. Analysis shows global...

onlinelibrary.wiley.com
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ERC-funded positions now open❗️❕❗️ Join the @GiuntaLab to understand human DNA evolution through the study of satellite repeats 🧬🧫🔬 APPLY here: euraxess.ec.europa.eu/jobs/2… Pls RT 🔄🗨️🙏
Image from Simona Giunta (@Simona_Giunta)
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Celebrating the incredible accomplishment of David being elected into the National Academy of Sciences! Congrats @davidjglassMD !!!
Image from Ryan White (@LordDNA)
Image from Ryan White (@LordDNA)
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The David Sinclair (@davidasinclair) $720,000,000 Resveratrol Train Wreck Video shoutouts: - Prof. Matt Kaeberlein (@mkaeberlein) - Prof. Brian Kennedy (@BKennedy_aging) - Dr. Peter Attia (@PeterAttiaMD) - Prof. Richard Miller - Prof. Jeffery Flier (@jflier)
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Yes it will happen 🤩! EMBO DDR meeting in Sounio is not open yet for registration but see below a teaser. Save the date! 👇
Image from Gaëlle Legube lab Chromatin Repair (@LabLegube)
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Excited to share this work exploring the profile of senolytic CAR T cells in physiological aging. Great collaboration with Inés Fernández-Maestre, that started @MSKCC and bore fruit @amor_lab @CSHL nature.com/articles/s43587-0…
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Very saddened to hear of Judy’s passing. I had the incredible opportunity to collaborate with Judy during my PhD. Judy was nothing short of an extraordinary scientist that shaped the field of aging & senescence to be what it is today. A true pioneer and champion in science.
Pankaj kapahi (@kapahi_pankaj) profile picturePankaj kapahi@kapahi_pankaj20 Jan 2024
I'm deeply saddened to share that we have lost a remarkable friend, a wonderful mentor and esteemed colleague, Judith Campisi. Judith's impact on those around her was profound and lasting. Her legacy will continue to inspire us all. Rest in peace, Judy. You will be greatly missed
Image from Pankaj kapahi (@kapahi_pankaj)
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A reminder that the abundance of 'house keeping' proteins varies significantly across cells and tissues. GAPDH (glyceraldehyde-3-phosphate dehydrogenase) is often slandered a 'house keeping' protein, and its abundance varies significantly across human tissues.
Image from Prof. Nikolai Slavov (@slavov_n)
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Writing a manuscript (or two 😉) from pure scratch after a few years… needless to say I’ve taken quite a few walks around the lab and campus to ummm… think (procrastinate). Anyways, stay tuned 📊📈💻
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Check out our latest review | LINE-1 retrotransposition and its deregulation in cancers: implications for therapeutic opportunities by @CarlosMendezPhD. Our thanks to @GenesDev. genesdev.cshlp.org/content/e…
Image from Kathleen Helen Burns (@KathleenHBurns)
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The lab decorated their pumpkins again this year! Some spooky, some cute, so many talented painters. Do I spy a repeat GDF11 👻?! Even spookier!
Image from Ryan White (@LordDNA)
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🐭🧬Our paper on locus-specific mouse L1 activity and regulation, led by the indomitable @Patricia_Grds is out @genomeresearch!🧬🐭 This study evolved from a simple question: what defines the mutagenic potential of a new L1 copy in vivo? genome.cshlp.org/cgi/content… A thread: 1/n
Image from Sandy Richardson (@RichardsonL1Lab)
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Ryan White retweeted
Xin Gu (@XinGu0317) profile picture
Xin Gu@XinGu031724 Aug 2023
Over the moon about my postdoc work ⁦@ScienceMagazine⁩ ! Ever wonder about how mammalian cells selectively degrade unwanted nuclear proteins without involving ubiquitination? Check out our paper on a non-canonical protein degradation mechanism! science.org/doi/10.1126/scie…
The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation

The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation

Midnolin associates with the proteasome to promote degradation of nuclear proteins through a ubiquitination-independent mechanism.

science.org
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Maybe the buildings should cut down on their flat whites and avocado toast.
Michael Li 李之樸 (@mcpli) profile pictureMichael Li 李之樸@mcpli17 Jul 2023
Manhattan office vacancies the cover story for the next issue of New York magazine
Image from Michael Li 李之樸 (@mcpli)
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Age-related gene expression signatures from limb skeletal muscles and the diaphragm in mice and rats reveal common and species-specific changes @TShavlakad83101, @davidjglassMD et al. skeletalmusclejournal.biomed…
Image from Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM (@agingdoc1)
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Grad student @keahi_dani studies the role of DNA repair in preventing medulloblastoma, the most common pediatric brain cancer. Her focus is on how developing brain cells are vulnerable to DNA damage and the pathways that protect them from becoming cancerous. #AAPIHeritageMonth
Image from Rockefeller University (@RockefellerUniv)
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