Homonormado 🏳️🌈 Muy hater.
Locus coeruleus
Joined September 2010
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Metilfenidato se salió del grupo . retweeted
LCIS involving collagenous spherulosis
Possible pitfall: Calling it DCIS
Dr. Wen. Modern Breast Pathology: Practical Updates from the International Society of Breast Pathology (ISBP) #USCAP #pathology #PathX
Metilfenidato se salió del grupo . retweeted
WHO 2026 Clarification on Immature Teratomas
Any amount of immature neuroepithelial tissue in a teratoma → diagnose as immature teratoma
Before calling it immature, rule out mimics:
- Cerebellar tissue (pic 1)
- Retinal tissue (pics 2 & 3; pic 3 was previously misdiagnosed as immature teratoma)
- Ependymal tissue (pic 4)
Dr. McCluggage. 2026 Annual Meeting of the International Society of Gynecological Pathologists
#ISGyP #Pathology #PathX
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WHO 2026 Terminology for Mucinous Neoplasms arising in Ovarian Teratomas:
Most show upper GI phenotype → use standard ovarian mucinous terminology (benign, borderline, or carcinoma) arising in/associated with teratoma
Small subset with lower GI (appendiceal-type) phenotype → call them low-grade mucinous neoplasm (appendiceal type) arising in teratoma (analogous to LAMN), or high-grade/appendiceal-type adenocarcinoma
Dr. McCluggage. 2026 Annual Meeting of the International Society of Gynecological Pathologists
#GYNpath #PathTwitter #OvarianPathology #PathX #ISGyP
Metilfenidato se salió del grupo . retweeted
Breast core. Referred as invasive ductal carcinoma.
E-cadherin was reported positive.
A) Agree: invasive ductal carcinoma
B) Disagree: invasive lobular carcinoma
C) Can't tell from H&E alone
Answer tomorrow at noon.
#Pathology #BreastPathology
Metilfenidato se salió del grupo . retweeted
For stereotactic breast biopsy: 💉
Calcifications 🪨 should be in the biopsy
When in doubt 🤔 , polarize b/c calcium oxalate crystals are polarizable!
Calcium phosphate won’t but you should be able to see that on H&E 🔬
If you still can’t find it, x-ray 🩻 the block
Metilfenidato se salió del grupo . retweeted
👉 A 70-year-old male with liver cirrhosis undergoes upper GI endoscopy, which reveals a gastric polyp.
🔬 ANSWER: Portal Hypertension-Associated Gastric Polyp
The histological findings include:
• Foveolar hyperplasia with elongated and tortuous gastric glands.
• Prominent proliferation and ectasia of vascular channels within the lamina propria.
• Stromal oedema and vascular congestion.
• Fibromuscular proliferation.
The prominent vascular component, in association with foveolar hyperplasia, is an important histological clue.
💎 Pathological pearl:
- Portal hypertension-associated gastric polyps are an uncommon manifestation of portal hypertension and may mimic conventional gastric hyperplastic polyps.
- The distinction relies on recognising the prominent vascular changes and correlating with the clinical history.
💡An interesting example of how systemic vascular alterations can manifest as distinctive gastrointestinal histopathological changes!
#GIPathology #Histopathology #PortalHypertension #GastricPolyp #PathologyTeaching
Metilfenidato se salió del grupo . retweeted
Carcinoid tumors arising in the ovary can be primary, of germ cell origin, but it is important to exclude metastatic low-grade neuroendocrine tumor
This distinction may be aided by molecular testing for loss of heterozygosity (LOH)
Teratomas (and mucinous ovarian neoplasms derived from teratomas) usually show extensive loss of heterozygosity reflecting their germ cell derivation
LOH is likely to be used in the future to help distinguish between primary and metastatic carcinoid tumor of the ovary in those cases where there is uncertainty.
Dr. Gilks. Gynecologic Pathology Masterclass
#USCAP #pathology #pathX
Metilfenidato se salió del grupo . retweeted
Low-grade serous neoplasia (serous borderline tumor or low-grade serous carcinoma) can transform to high-grade carcinoma
This is more common at recurrence but can occur at initial diagnosis, as in this case
The high-grade component should not be called high-grade serous carcinoma. It differs clinically and molecularly from classic high-grade serous carcinoma. Using the same name can cause confusion and inappropriate treatment
Transformation is recognized by increased nuclear atypia and mitotic activity compared with the low-grade areas. It often appears during treatment, marked by a shift from slow to rapid progression
p53 immunostaining is not reliable, as TP53 mutations are present in only about 40% of these cases
Diagnosis remains somewhat subjective
Final diagnosis for this case: Serous borderline tumor with transformation to high-grade carcinoma
Dr. Gilks. Gynecologic Patholology Masterclass #PathX #USCAP #pathology
Metilfenidato se salió del grupo . retweeted
High-grade DCIS associated with metaplastic carcinoma.
Even if the entire tumor is keratin-negative, the presence of DCIS supports the diagnosis of metaplastic carcinoma (see pic)
When other features are lacking, sample extensively. Go back to the specimen and take more sections from the periphery—leaf-like architecture (phyllodes) and DCIS are often found there
Dr. Wen. Interactive microscopy, Practical Updates from the International Society of Breast Pathology (ISBP) #USCAP #PathX #pathology
Metilfenidato se salió del grupo . retweeted
What happened to mixed ovarian carcinomas?
Most cases called “mixed” were just one tumor type with morphologic mimicry (often high-grade serous carcinoma looking endometrioid or clear-cell)
They mostly disappeared from the WHO 4th edition (2014). They returned in the 2020 WHO, but true mixed carcinomas are rare (<1%). The main real ones are endometriosis-associated endometrioid + clear cell
Pic below: Classification rules for ovarian carcinomas since 2014 WHO
Dr. Gilks. Gynecologic Pathology Masterclass
#USCAP #pathology #pathX
Metilfenidato se salió del grupo . retweeted
Ovary: Changes to WHO classification (2026)
- Ovarian tumors are separated into epithelial and non-epithelial ovarian tumors (germ cell tumors, sex-cord stromal tumors)
- Fibrosarcoma: REMOVED
- Rete adenocarcinoma: REMOVED
- Wolffian tumors moved to broad ligament chapter
Dr. Nucci. Gynecologic Pathology Masterclass #USCAP #pathology #PathX
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Breast WHO 6th Edition Update: Neuroendocrine Tumors
• Large cell neuroendocrine carcinoma of the breast has been eliminated as a separate entity
• Tumor looks like a breast primary with moderate-to-strong (or diffuse weak but unequivocal) NE marker expression → IBC-NST with neuroendocrine differentiation. Clinical management is unchanged; treat and sign out as regular IBC-NST
• Tumor looks morphologically like a NET with strong, diffuse NE marker expression → Primary breast NET (exceptionally rare). Diagnose only after metastatic NET is ruled out
• Tumor looks morphologically like small cell carcinoma → Breast small cell carcinoma (rare). Diagnose only after metastasis (usually lung) is ruled out
Dr. Kimberly Allison, 2026 Diagnostic Pathology Update
#pathology #USCAP #PathX #BreastPath
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Breast - Micropapillary carcinoma can show a distinctive HER2 IHC pattern
- Basolateral or lateral, U-shaped membrane staining
- Score as equivocal (2+) when staining is moderate to intense but incomplete (in >10% of tumor cells) → reflex to FISH
- This pattern can be seen in some micropapillary cancers that are HER2 gene amplified (CAP Breast Biomarker Protocol, 2026).
Dr. Allison. 2026 Diagnostic Pathology Update #USCAP #pathology #PathX
Metilfenidato se salió del grupo . retweeted
For the first time, ADCs deliver a statistically positive truck test in sarcomas! 🛻
Hey @PTarantinoMD ! I guess we can say this passes the truck test?
glad to see #sarcoma at the plenaries both at @ASCO and @myESMO
Metilfenidato se salió del grupo . retweeted
Favorable types of breast carcinoma - Systemic adjuvant treatment
Minimal treatment
-Endocrine treatment only "considered" when < 3 cm
-Only consider chemotherapy if lymph nodes positive
Caution: Need strict criteria to diagnose these types. Tubular, Mucinous and Cribriform carcinoma: Should be pure (>90% as classified on the surgical resection not the core biopsy alone)
Dr. Allison. 2026 Diagnostic Pathology Update #USCAP #pathology #pathX
