Husband, father to three wonderful kids, gpa to two cats. Stanford cardiologist scientist. genetics of rare disease. UDN GREGoR MoTrPAC. @matt@genomic.social
United States
Joined October 2014
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Matthew Wheeler retweeted
Don't miss your chance to learn about #NIH_CFDE #data resources and a new platform for querying the Gene Expression Omnibus (GEO) with #gene sets! Tune in to this webinar on Fri 5/31 at 1PM ET. Learn more: bit.ly/3vX6iJK
ALT Alt text: NIH Common Fund logo is on the top left corner on a blue background and orange accents with a picture of Avi Ma’ayan and Giacomo Marino. Text reads: Common Fund Data Ecosystem. Public Webinar. Learn about the LINCS Data Coordinating Center (DCC), the CFDE Data Resource Center (DRC), and a new platform that allows you to query gene sets (RummaGEO). Learn more: https://bit.ly/3vX6iJK. Friday, May 31. 1:00 - 2:00PM ET. CFDE Knowledge Center (KC). Avi Ma’ayan, PhD. Speaker. Giacomo Marino. Speaker.
Now online from @me_lindholm and @DavidAm79279702 and colleagues of the #MoTrPAC consortium - explore the underlying data at motrpac-data.org and analysis R packages led by @nicolergay at github.com/MoTrPAC/MotrpacRa…
New! Online now: The mitochondrial multi-omic response to exercise training across rat tissues dlvr.it/T6KTp8
If you’re looking for the #MoTrPAC @Nature paper after exploring the data at motrpac-data.org here is the pdf link: rdcu.be/dGpGX
Explore the underlying data at motrpac-data.org
This week in Nature: Exercise effects - Mapping the molecular changes induced by endurance
Browse the full issue: nature.com/nature/volumes/62…
Matthew Wheeler retweeted
To explore this data, go to motrpac-data.org/. Here you can download data, look at how exercise regulates your favorite genes/proteins/metabolites across tissues or interactively compare training-induced tissue- and sex-specific enrichments in your tissues of interest. /n
Matthew Wheeler retweeted
The genetics of human performance go.nature.com/2VIjZKt #Review by @danseungkim, @MWheelerMD & @euanashley
@StanCVFellows @StanfordDeptMed @Stanford
Free to read here: rdcu.be/cxKrt #SharedIt
Moving day! #AcademicTwitter See you at genomic.social thanks for all the fish
So amazing to see this preprint out - incredible work by the entire #MoTrPAC team and especially co-leads @nicolergay @DavidAm79279702 @PierreMichelJ10! Thanks to @NIH_CommonFund for continuing support
We are thrilled to share the preprint for the Molecular Transducers of Physical Activity Consortium’s (aka MoTrPAC) first major multi-omic multi-tissue exercise study and data resource! biorxiv.org/cgi/content/shor…
Matthew Wheeler retweeted
All all data underlying MetaDome.app , including annotations of all human codons to @PfamDB-based evolutionary equivalent positions, are now available and ready to be plugged into your analysis pipeline.
Available here:
zenodo.org/record/6625251
Excited to see #mavacamten approval for patients with symptomatic obstructive hypertrophic cardiomyopathy! Spudich lab @stanford fundamental biophysics facilitating MyoKardia small molecule, trials @StanfordMed since 2015 - SAD, EXPLORER, VALOR, MAVA-LTE…more work to be done 1/4
Importantly Mavacamten is first in class, with other sarcomere modulators in trials…we hope to learn more through clinical roll-out and PMA studies. Thanks to collaborators at MYOK and BMS. Thanks to Masataka Kawana and our clinical research team over the past 7 years…3/4
Congrats to rising star @ADevareddyMD @StanfordMedRes for presenting our results analyzing progression of disease in the pre-#mavacamten era using serial CPET testing in #HCM patients @StanfordMed #ACC22 @euanashley @jwc14 @Ron_Witteles
Article Ideation by Artificial Intelligence vs Actual Individuals bmj.com/content/375/bmj-2021…
Matthew Wheeler retweeted
Our featured article: The genetics of human performance go.nature.com/2VIjZKt #Review by @danseungkim, @MWheelerMD & @euanashley
@StanCVFellows @StanfordDeptMed @Stanford
Free to read here: rdcu.be/cxKrt #SharedIt
Matthew Wheeler retweeted
And TOMORROW from 12-1pm Pacific Time, we will be welcoming pioneers in clinical cardiovascular genetics, Dr. Richard Bagnall, PhD and Professor Chris Semsarian, all the way from Australia! Register here: bit.ly/32iAEHA.
@rdbagnall @CSHeartResearch
Matthew Wheeler retweeted
Who has #LongCovid? A #BigData approach medrxiv.org/content/10.1101/… @ncats_nih_gov @data2health #EHR #TeamScience at unprecedented scale in #N3C!
Intellia, with first results, delivers a 'landmark' for CRISPR gene editing biopharmadive.com/news/intel… via @BioPharmaDive
But we will have to see if there are any longer term unintended off target (both tissue and gene) effects that this prelim report don’t address. Reminder for TTR patients out there there are efficacious treatments approved and available, though cost is a real concern