Twitter account for Mattias Mannervik lab at Stockholm University. Transcription and epigenetics in Drosophila.
Joined February 2021
- Tweets61
- Following50
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Have you ever wondered how chromatin states shape developmental trajectories? In our preprint, we address this question using single-cell nanoCUT&Tag, a method developed by Marek Bartosovic @marekbartosovic, biorxiv.org/content/10.64898…
We tested this idea by partially depleting H3K27me3 in the mesoderm, which led to reactivation of genes normally expressed in closely related cell populations.
ALT Epigenetic landscapes for the Krüppel gene locus in wild-type embryos and embryos with a mesoderm-specific knockdown of Polycomb catalytic subunit E(z), which deposits H3K27me3. After knockdown, the repressive "hill" diminishes along the muscle (M) trajectory, and Krüppel is ectopically expressed in muscles.
Led by Sergei Pirogov
@biologsp, with key contributions from Artem Ilin, Aleksander Purik, and collaborators.
Curious about epigenetics, gene regulation, and developmental biology?
Apply for the PhD position in Mannervik lab at Stockholm University!
We use single-cell genomics and genetic approaches to uncover how cells acquire their identities during development.
Explore the chromatin landscape with us!
Apply here: su.varbi.com/what:job/jobID:…
Mannervik Lab retweeted
Using PRO-seq and CUT&Tag, we found that CBP activates zygotic genes in two steps:
- It helps recruit RNA Pol II to promoters without requiring catalytic activity.
- Its catalytic acetyltransferase function then triggers pause release.
Mannervik Lab retweeted
Excited to share our new paper in @MolecularCell Mol Cell: "Catalytic-dependent and independent functions of the histone acetyltransferase CBP promote pioneer-factor-mediated zygotic genome activation" — the big part of my PhD! cell.com/molecular-cell/full…
Mannervik Lab retweeted
Horizon Europe research-and-innovation.ec.e…
SCENTINEL members are grateful to HE for supporting Drosophila Research and the transfer of expertise in single cell omics across Europe
Mannervik Lab retweeted
Welcome to SCENTINEL!
a Horizon Europe Twinning collaborative initiative between
@IMBB_FORTH (Delidakis lab, Lavigne lab, Genomics CF)
@IRBBarcelona (Bioinformatics and Functional Genomics CF)
@IJMonod (Konstantinides lab)
@IGBMC (Giangrande lab)
@Stockholm_Uni (Mannervik lab)
Mannervik Lab retweeted
📢 One of the @FEBS_Letters #PosterPrize awarded at the Transcription & Chromatin #EMBLTranscript conference in Heidelberg goes to🥁.... Sergei Pirogov!
Congratulations, Sergei! 👏👏👏
@MannervikLab @Stockholm_Uni @EMBLEvents
Mannervik Lab retweeted
✳️✳️✳️✳️✳️✳️Please RT !! ✳️✳️✳️✳️✳️✳️
Register NOW For our #DevBio Meeting ❤️🪰🐁🪱🐸
In May 28-31, 2024
in spectacular Bergen (Norway 🇳🇴☀️⛰️⛵️)
Look at our marvellous speakers line-up ⬇️
tinyurl.com/NDEVMSS24
📢 Registration is open!!
We are thrilled to announce registration for the 'Nordic Developmental Biology Societies & Michael Sars Symposium Joint Meeting' on May 28-31, 2024 is open!
Organized in collaboration with @swedbo & FSDB @UiB
✨REGISTER HERE ➡️ tinyurl.com/NDEVMSS24
Want to understand how gene expression programs form during development? Read our latest paper @GenomeBiology. We have profiled tissue-specific transcriptional and epigenomic landscapes forming as cells adopt distinct fates during Drosophila embryogenesis. rdcu.be/du0FU
To explore the dynamics of DV gene induction, we collaborated with the @sandberglab to infer gene burst kinetics transcriptome-wide from scRNA-seq data. We find DV genes are characterized by the capacity for large bursts of transcription, but with tightly controlled frequencies.
A big thanks to Rickard Sandberg and Christoph Ziegenhain @chris_zie for the nice collaboration on bursting and to Johan Reimegård @johan_rei for all bioinformatic help. It’s been a true pleasure to collaborate on this exciting project!