life scientist: molecular biologist, immunologist, cell ecologist, macrophage behaviorist, phage breeder and wild microbiome archivist;
University of Oxford, UK
Joined March 2016
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biorxiv.org/content/10.1101/…
We propose #T1D is primarily caused by immune responses against microbial-enzyme transketolase which contains key insulin-epitope. Our findings link microbial metabolism of polysaccharides, dysbiosis and antigen-specific immune responses to insulin.
Marcin L Pekalski retweeted
Microplastics are everywhere.
This timely editorial in @NatureMedicine calls for an urgent deeper understanding of the effects of these particles on human health:
nature.com/articles/s41591-0…
Marcin L Pekalski retweeted
When it comes to #thymus protection against autoimmunity, producing normal thymic regulatory T cells is more important than deleting self-reactive T cells, @UZH_en researchers conclude from studies in mice.
Check out the 2021 research: scim.ag/64L #WeekendReads
Marcin L Pekalski retweeted
Smoking changes adaptive immunity with persistent effects. 🚬 nature.com/articles/s41586-0…
Marcin L Pekalski retweeted
Get it while it's hot! The newest @NatureComms publication on thymic epithelial cells by @FabianJKlein from the Holländer lab at @IdrmOxford @UniofOxford is now online:
nature.com/articles/s41467-0…
Marcin L Pekalski retweeted
#CuttingEdge from @MelicharLab and John H. White @mcgillu | #Autoimmune regulator #Aire is a coactivator of the #VitaminDReceptor
#ReadTheJI #immunology 👉 ow.ly/uLFj50P5smX
Marcin L Pekalski retweeted
New research suggests antimicrobial used to promote livestock growth breeds bacteria more resistant to our natural defences.
These findings add to the current body of evidence on the negative impact of antibiotics beyond the gut:
ow.ly/TIal50OH93B
Marcin L Pekalski retweeted
⚡️Residents of Kherson region, save your pets from drowning - the Ministry of Internal Affairs of Ukraine
"If you evacuate, take care of pets: unchain them, let them out of their cages or, if possible, take them with you. Give the furry ones a chance to be saved," the message says.
👉 Follow @Flash_news_ua
Marcin L Pekalski retweeted
Do you work in biomedical #research? Do you also question your #antibodies? Dodgy antibodies waste time & $$$ + drive the reproducibility crisis. Let's talk about it!
We've validated >50❗️Tau antibodies: rb.gy/jf247
Here's what we learnt & why it matters
A 🧵 1/n
Marcin L Pekalski retweeted
In Australia, the southern greater glider population’s habitat could be destroyed by logging.
"To protect this species, we must prevent further logging of Australia’s native forests," argues a new #LetterToScience. scim.ag/zl
Marcin L Pekalski retweeted
By 2050, an estimated 152 million people will affected by dementia globally. @uk_biobank ’s repeat imaging project could provide crucial information that may assist with diagnosis and treatment of #Alzheimers and related conditions bit.ly/3RBHxII
Marcin L Pekalski retweeted
We've been robbed
The wildlife we have today is merely a wisp of it should be
Marcin L Pekalski retweeted
Wax worm saliva can oxidise and depolymerise polyethylene, one of the most produced and sturdy polyolefin-derived plastics @NatureComms #plasticpollution nature.com/articles/s41467-0…
Marcin L Pekalski retweeted
The tongue is a unique barrier organ constantly exposed to environmental pathogens. Researchers have mapped the immune cell network of the tongue during development, health, and disease. elifesciences.org/articles/7…
ALT 3D reconstruction of mouth tongue tissue stained in blue, green, red and white
Marcin L Pekalski retweeted
In the Zagros mountains of Iran, perfectly blended into the gypsum and limestone rocks is a snakes entire body
but the tip of its tail which resembles a spider, luring insectivorous birds within striking range. This is the spider-tailed horned viper 1/🧵
Marcin L Pekalski retweeted
Check out this incredible avalanche footage from the Tian Shan mountains in Kyrgyzstan. Luckily, everyone survived. Account: cutt.ly/fLkOldS
Marcin L Pekalski retweeted
A new study in mice suggests that a majority of IgA in the gut is selected to recognize and react to distinct gut bacterial species instead of demonstrating polyspecificity. @IcahnMountSinai @jeremiahfaith1
fcld.ly/k5fsau8
Very fascinating ecology of IL-2.
New research from @LabListon investigates the #cytokine network of #IL2. Using a new genetic tool, the authors show that response to IL2 depends on the cellular source. This explains old mysteries of clinical adverse events and provides new targets bit.ly/3MMoM1X
Interesting! Extinction of microbiomes changes fine-tuned ecology of the immune responses to commensals. This is particularly important during infant weaning when regulatory T cells to self epitopes are amplified by commensals mimics. See example for #T1D medrxiv.org/content/10.1101/…
Excited to announce this work is out today in @ScienceMagazine- “Robust Variation in Infant Gut Microbiome Assembly Across a Spectrum of Lifestyles.” We analyzed feces from infants across the globe to understand how lifestyle affects the early microbiome science.org/doi/10.1126/scie…
