Mark Murphy (@MarkinHPI) header
Mark Murphy (@MarkinHPI) profile picture

Mark Murphy

@MarkinHPI

Biochemist/Microbiologist; Outcomes of host interaction with pathogens; Consequences of innate immune dysfunction in airways diseases ORCiD: 0000-0001-5624-1338

 RCSI, Beaumont Hospital Dublin
linkedin.com/in/mark-murphy-a45764b7
Joined January 2011
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Photo by Mark Murphy (@MarkinHPI)Photo by Mark Murphy (@MarkinHPI)Photo by Mark Murphy (@MarkinHPI)Photo by Mark Murphy (@MarkinHPI)Photo by Mark Murphy (@MarkinHPI)Photo by Mark Murphy (@MarkinHPI)Photo by Mark Murphy (@MarkinHPI)Photo by Mark Murphy (@MarkinHPI)Photo by Mark Murphy (@MarkinHPI)Photo by Mark Murphy (@MarkinHPI)
Remember to submit during a #CallforPapers like this #ArticleinPress, Citrullination, a novel post-translational modification of elastin, is involved in #COPD Pathogenesis (Mark Murphy et al. @RCSI_Irl): ow.ly/ow4G50Teifc
Image from AJP-Lung Cellular and Molecular Physiology (@AJPLung)
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On the cover of @MedCellPress - our Phase 2 RCT of alpha-1 antitrypsin for #COVID19. Cool cover illustration! @AlphaFriend @Alpha1_Ireland @RCSI_Irl @stjamesdublin @Beaumont_Dublin @Beaumont_ICU @NUIGalwayMed
Med by Cell Press (@MedCellPress) profile pictureMed by Cell Press
@MedCellPress12 Apr 2022
New issue! Bringing you a trial of the serine protease inhibitor alpha-1 antitrypsin as an anti-inflammatory therapeutic for patients with ARDS secondary to COVID-19, more research on Omicron, and a Commentary on AI in medicine.
Image from Med by Cell Press (@MedCellPress)
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Delighted to see our #COVID19 clinical trial paper feature on the cover of the most recent issue of @MedCellPress link to full text: cell.com/med/fulltext/S2666-… @RCSI_Irl @RCSI_Research @RCSI_RespLab
Image from Natalie McEvoy (@Natalie_McEvoy)
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ONLINE NOW: McElvaney et al present the results of a randomized trial of alpha-1 antitrypsin for patients with acute respiratory distress syndrome secondary to COVID-19. Circulating IL-6 and other pro-inflammatory markers were decreased at one week in the treatment group.

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Are you a researcher or academic? Got 5 minutes? @ICoRSA_News wants to know a bit about your experience of research career progression and precarity. Check out their Global Survey on Research Career Progression: surveymonkey.com/r/GFD2R3P
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Mark Murphy retweeted
Cell (@CellCellPress) profile picture
Cell@CellCellPress28 Dec 2021
Now online! Complement activation induces excessive T cell cytotoxicity in severe COVID-19 dlvr.it/SG8dfp
Complement activation induces excessive T cell cytotoxicity in severe COVID-19

Complement activation induces excessive T cell cytotoxicity in severe COVID-19

Generation of the C3a complement protein fragment by SARS-CoV-2 infection drives differentiation of a CD16-expressing T cell population that associates with severe COVID-19 disease outcomes.

cell.com
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We are hiring a postdoctoral researcher on our SFI-Funded AdaptaLox project, looking at the links between low oxygen & bacterial adaptation in #CysticFibrosis. Details ucd.ie/workatucd/jobs/ ref: 013893 Come & work with us! @UCD_Conway @UCD_SBBS @UCDResearch #JobFairy please RT
O’Brien science centre, UCD with clear blue sky in the background

ALT O’Brien science centre, UCD with clear blue sky in the background

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RTs really appreciated, great postdoc opportunity to work at the cutting edge of human respiratory immunology. Closing date September 30th
Image from Annie Curtis - Clock Lab RCSI (@curtisclocklab)
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At Vertex, we’re investigating potential treatments for alpha-1 antitrypsin deficiency. We’re excited to join this week’s #ILC2021 hosted by the European Association for the Study of the Liver alongside experts in the field. Learn more about our #AATD program. @EASLNews
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Less than two weeks to go to apply. Interested in a postdoc combining circadian biology, metabolism and respiratory disease, look no further :) Unique opportunity to work between my lab at that of the McElvaney group. RTs most welcome. my.corehr.com/pls/rcsirecrui…
Image from Annie Curtis - Clock Lab RCSI (@curtisclocklab)
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I put together a blog post on why child poverty is a significant problem in Ireland and why we need to set a target for its elimination. It's here on the @PsychologistsI site psychangeireland.wixsite.com…
Consistent Child Poverty Is a Problem — Let's Set a Target for its Elimination

Consistent Child Poverty Is a Problem — Let's Set a Target for its Elimination

A key tool for the elimination of child poverty is the setting of poverty reduction targets as part of a comprehensive strategy.

psychangeireland.wixsite.com
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We have a fully funded PhD project available to study neutrophilic inflammation in chronic lung disease. A great opportunity for the right candidate - our lab is friendly and fun. Come and work with @MereteLong @KeirHolly @Shoemelia on a great project! findaphd.com/phds/project/ch…
Characterisation of neutrophil reprogramming in chronic lung inflammation at University of Dundee...

Characterisation of neutrophil reprogramming in chronic lung inflammation at University of Dundee...

PhD Project - Characterisation of neutrophil reprogramming in chronic lung inflammation at University of Dundee, listed on FindAPhD.com

findaphd.com
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Characterization of the Inflammatory Response to Severe COVID-19 Illness 🔓 Open Access 🔗 ow.ly/OVVz50BsA6H
Image from ATS Blue Journal (@ATSBlueEditor)
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Mark Murphy retweeted
ATS Red Journal (@AJRCMB) profile picture
ATS Red Journal@AJRCMB20 Feb 2020
Tissue-Resident Alveolar Macrophages Do Not Rely on Glycolysis for LPS-induced Inflammation ow.ly/pSgG50ymAgT
Image from ATS Red Journal (@AJRCMB)
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Postdoc opportunity to work on neutrophils in Berlin mpiib-berlin.mpg.de/1975867/…
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Mark Murphy retweeted
Addgene (@Addgene) profile picture
Addgene@Addgene1 Nov 2019
Check out this CRISPRi toolkit for silencing gene expression in #Burkholderia from Silvia Cardona's lab @cardona_lab. They also putatively identified 67 genera of Proteobacteria that could be modified with this toolkit. A great tool for #microbiologists! hubs.ly/H0lz54T0
Image from Addgene (@Addgene)
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Right, the Ireland and Brexit thread. Why the backstop is not annexation, might be undemocratic but that could be negotiated by a mature UK Government, and is required because of history, identity and normal border procedures 1/
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Year after year: when the mist would start To lift off fields and inlets, when morning light Would open like the grain of life being split, Day in, day out, I’d come alive again
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Our @SciReports paper on immune response of bovine cells to S. aureus lineages, co-first-authored with @MarkinHPI is finally out! So excited to see the first part of my PhD published! #published #theups nature.com/articles/s41598-0…

The in vitro host cell immune response to bovine-adapted Staphylococcus aureus varies according to...

Scientific Reports - The in vitro host cell immune response to bovine-adapted Staphylococcus aureus varies according to bacterial lineage

nature.com
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Staph aureus lineages likely use different strategies when infecting bovine cells, highlighting a diversified evolution and the shortcoming of studying only a single strain (a project we worked on while I was at Teagasc): disq.us/t/3dqe80f
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