Postdoc in the Arnold group at Caltech working on chemoenzymatic synthesis. Former member of @ProfDaveLeigh group. 🇮🇪
Pasadena, CA
Joined October 2020
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Martin Power retweeted
What if AI could invent enzymes that nature hasn’t seen? 👩🔬🧑🔬
Introducing 🪩 DISCO: Diffusion for Sequence-structure CO-design
14 rounds of directed evolution and over a year of wet lab work. That's what it took to engineer an enzyme for selective C(sp³)–H insertion, one of the most challenging transformations in organic chemistry.
DISCO surpasses this with a single plate. No pre-specified catalytic residues, no template, no theozyme, no inverse folding, just joint diffusion over protein sequence and structure.
📝 Blog: disco-design.github.io/
📄 Paper: arxiv.org/abs/2604.05181
💻 Code: github.com/DISCO-design/DISC…
Martin Power retweeted
A decade-long passion project led by John Billingsley and made possible by uninterrupted collaboration with the great team at @GargLab. Propellane alkaloid discovery, biosynthesis and total synthesis. @UclaCBE @uclachem @eXoZymes
pubs.acs.org/doi/10.1021/acs…
Martin Power retweeted
🚨 New paper in Angewandte Chemie Novit! 🚨
Metal-free active template synthesis of catenanes — no strong binding or added templates needed!🧪
Huge thanks to Jiankang, Patrick, @enzoolivieri4, and Prof. @ProfDaveLeigh for the supervision!
👉 onlinelibrary.wiley.com/doi/…
Martin Power retweeted
#Enzymatic Stereodivergent Synthesis of Azaspiro[2.y]alkanes by Jennifer L. Kennemur, Yueming Long, Catherine J. Ko, Anuvab Das, and @francesarnold at @CaltechCCE in @J_A_C_S pubs.acs.org/doi/10.1021/jac…
Martin Power retweeted
Fully funded PhD opportunity in the design, synthesis and characterisation of artificial molecular machines - 2 years at the University of Manchester; 1-2 years at Peking University. Open only to non-Chinese nationals. If interested, please email me asap. findaphd.com/phds/project/uo…
Martin Power retweeted
15 PhD positions open
Motorized nanomachines: fundamentals, innovations, applications
cordis.europa.eu/project/id/…
Academic labs (Feringa, Lehn, Diez, Simmel, Credi, Duwez, Giuseppone) and companies (Soprema, Syensqo)
Details for applications available soon through EURAXESS website
Martin Power retweeted
PhD positions (SNSF) available at the University of Basel (Switzerland🇨🇭)! Join a new research group working on innovative catalytic pathways to produce endergonic/endothermic molecules🔥.
For more details: endergo.net/joinus.html & [email protected]
Martin Power retweeted
A Catalysis-Driven Dual Molecular Motor | Journal of the American Chemical Society @OfficialUoM pubs.acs.org/doi/10.1021/jac…
Martin Power retweeted
Check out how we made a minuscule motor rotate 24 times in one direction on its own! Huge thanks to all involved, especially @ProfDaveLeigh for making this work possible @ACSPublications @HuakuiLiu @AxelTroncossi @StefanBorsley @benjamino_acid @AlexBetts95 pubs.acs.org/doi/10.1021/jac…
Out now in Nature (nature.com/articles/s41586-0…)! Very happy to have been a part of this journey. We have integrated a catalysis-driven molecular motor into a polymer gel network to better understand the molecular-level transduction of chemical energy to mechanical force. (1/5)
The direction of motor rotation and therefore polymer entanglement can be changed by switching the chirality of the chemical fuel, enabling a powered expansion and re-contraction of the gel. (4/5)
A big thank you to our excellent first author Peng-Lai, @StefanBorsley, @ProfDaveLeigh, and our collaborators Alessandro and @GiusepponeLab in Strasbourg for making this happen. (5/5)
Very happy to be starting my postdoc at the Arnold group at Caltech. Time for a new biocatalysis-themed adventure.
Martin Power retweeted
Budding molecular magicians are invited to apply for a 4-year PhD studentship on catalysis-driven molecular machinery (e.g. onlinelibrary.wiley.com/doi/…; nature.com/articles/s41586-0…; etc) available in my group, autumn 2025 start: tinyurl.com/kdw6mtcr. Position open until filled😃
Martin Power retweeted
Just in time for Halloween💀☠️ skeletal editing of rotaxanes! @MaximeG43877226, Jess & Dan use @LevinChem’s N-deletion reagent to remove template site of dibenzylammonium rotaxanes enabling synthesis of otherwise inaccessible structures.Out now in @J_A_C_S pubs.acs.org/doi/10.1021/jac…
Martin Power retweeted
RT appreciated:
My lab is recruiting several Ph.D.s and Postdocs excited to build synthetic cells that undergo Darwinian evolution.
The backgrounds that we need for include biochemistry, synthetic biology, and systems chemistry.
Details: boekhovenlab.com/openings/
Martin Power retweeted
Don't miss this #OpenAccess review by Romain Jamagne, Martin J. Power, Zhi-Hui Zhang, Germán Zango, Benjamin Gibber and @ProfDaveLeigh
"Active template synthesis"
Read the full review here 👇
pubs.rsc.org/en/content/arti…
