@Mauri_group

Mauri lab based @UCL. Our research interests include B cells, regulatory B cells and their roles in autoimmune disease and cancer. #lupus #arthritis #cancer

 London, England
Joined March 2016
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Thrilled to share our new preprint! 🎉 We uncover a novel subset of double negative (DN1) Bregs expanded in RCC, located within immature tertiary lymphoid structures, that suppress cytotoxic T cell activation. Led by @DrZaraBaig & Izzy, with support from all our collaborators.
bioRxiv Immunology@biorxiv_immuno13 Jul 2025
Tumor-infiltrating CD27-IgD- regulatory B cells suppress cytotoxic CD8+T cell responses in renal cell carcinoma biorxiv.org/content/10.1101/… #biorxiv_immuno

Tumor-infiltrating CD27-IgD- regulatory B cells suppress cytotoxic CD8+T cell responses in renal...

B cells play a pivotal role in shaping the tumor microenvironment (TME) and tertiary lymphoid structures (TLS), but the functions of specific B cell subsets in cancer pathogenesis remain unclear....

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Organoid co-culture and organ-on-chip systems are transforming how we study immune–epithelial interactions, enabling more precise, patient-relevant models of disease 🧬 🔗 doi.org/10.1093/cei/uxae004 #Immunology #Organoids #Microfluidics #PrecisionMedicine

Revolutionizing immune research with organoid-based co-culture and chip systems

Potential use and translational applications of patient-derived organoids are very diverse. Such models have revolutionized research in immunological disea

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📢 This open‑access study identifies PSMB8 as a biomarker predicting proton pump inhibitor response in paediatric eosinophilic esophagitis, supporting more personalized treatment decisions. 🔗 vist.ly/5ixam
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This open‑access study shows the β‑blocker nebivolol prevents T‑cell exhaustion and boosts cytotoxicity against breast cancer cells via β₂‑adrenergic receptor–dependent signalling, highlighting a potential new immunomodulatory strategy. vist.ly/5h4ta

Nebivolol prevents exhausted T cells and enhances cytotoxicity against MCF-7 breast cancer cells in...

Prolonged TCR/CD3 and CD28 stimulation drives sustained NFATc1 signaling and TOX expression, resulting in increased inhibitory receptor expression and redu

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Join us in celebrating 60 years of pioneering clinical and translational immunology research! Explore our special collection showcasing the most-cited and widely-read articles that shaped our legacy: vist.ly/5hjvm #CEIat60
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🧬 How does ageing with frailty reshape immune responses? This open‑access study links altered neutrophil signalling to impaired chemotaxis and increased ROS/NET production, highlighting key features of inflammageing. 👉 vist.ly/5ihau #ImmuneAgeing26

Altered neutrophil signalling linked to impaired chemotaxis and increased ROS and NET production in...

In this study we have combined RNAseq with functional experiments to describe the phenotype of neutrophils from people with frailty. We found that frailty

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A great day at #LIG26, exploring how the microbiome, diet, pollution and stress affect immunity. Lots of fascinating research being shared today 🙂 If you're here, free to come and talk to our Journals Manager, Laura Franklin, about publishing your research in the BSI journals!
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🔬 New research suggests that stronger IgA and IgG antibody responses may help protect against active TB. Elevated salivary IgA also highlights the potential importance of mucosal immunity. doi.org/10.1093/cei/uxaf001
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IFNγ from activated CD4⁺ T cells is a key driver of B‑cell differentiation and autoantibody production in IMQ‑induced lupus mice. IFNγ deficiency dramatically reduced disease features, a promising immune pathway for future SLE therapies. doi.org/10.1093/cei/uxaf079

Pathogenic role of IFNγ from activated CD4+ T cells in lupus model mice induced by topical treatm...

CD4⁺ T cell–derived IFNγ has been suggested to contribute to SLE, but its role in B cell pathology remains unclear. Using the IMQ-induced lupus mouse model

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What does living past 105 look like immunologically? Increased Vδ1 TEMRA, CD8+ T and NK cells suggest a resilient immune system shaped by lifelong adaptation. 🧬 doi.org/10.1093/cei/uxad132
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In this review, Mansi Patel and colleagues explore how long non-coding RNAs influence neuroimmune interaction in oral squamous cell carcinoma. 📖 doi.org/10.1093/cei/uxag007 #Immunology #CancerResearch #Neuroimmunology

LncRNAs at the frontline of neuroimmune crosstalk in oral cancer

This review examines the current role of long non-coding RNAs (lncRNAs) in the neuroimmune crosstalk in oral squamous cell carcinoma and specifically their

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Early splenectomy delays inflammation and reduces joint damage in a mouse model of autoimmune arthritis, highlighting a surprising protective role when done at early stages. 🧬 doi.org/10.1093/cei/uxae013 #Immunology #Autoimmunity #Arthritis

Splenectomy at early stage of autoimmune arthritis delayed inflammatory response and reduced joint...

We propose that splenectomy in early stages of autoimmune arthritis could be beneficial because it prevents bone and cartilage destruction in the joints. T

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📣 Excited about engaging the public in #immunology? Apply for the BSI Communication & Engagement Grant! Up to £1,000 for projects that inspire, educate and build trust in science. Deadline: 1 October 2026! Apply here: bit.ly/3Y9j8gm
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In Sjögren’s syndrome, salivary gland epithelial cells act not just as targets but as drivers of autoimmune inflammation. Their altered signalling and antigen‑presenting features can shape and sustain immune dysregulation. 🔗 doi.org/10.1093/cei/uxaf078

The ‘target tissues’ as orchestrators of autoimmune responses: the paradigm of Sjögren’s syndrome

Crosstalk between salivary gland epithelial cells (SGECs) and immune populations in Sjögren’s disease.

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🧬 Could extracellular microvesicles help track rheumatoid arthritis activity? Anti-TNFα therapy reduced EMVs carrying disease-associated protein modifications, alongside improvements in disease activity, highlighting their potential as biomarkers. 🔬 🔗 doi.org/10.1093/cei/uxag044

Post-translational modifications in extracellular microvesicles from plasma of rheumatoid arthritis...

In RA patients anti-TNFa therapy significantly reduces the concentration of circulating EMVs.In RA patients anti TNFa therapy significantly reduces citrull

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Targeting T-cell integrins has become an important therapeutic strategy for autoimmune and inflammatory diseases. This review covers the biology of integrins and the latest advances in integrin-targeting treatments. 🔗 doi.org/10.1093/cei/uxad093
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Altered B-cell homeostasis and elevated IL10/TNFA expression in #CIDP suggest chronic humoral immune activation. Immune markers also correlated with nerve fiber loss and disability, highlighting potential biomarkers of disease activity. doi.org/10.1093/cei/uxad103 #Neurology
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Could the environment hold the key to better immune therapies? 🌍 #LIG26 Join us in London this September to explore how diet, the microbiome, pollution and stress influence immunity, and open new avenues for prevention and treatment. Register now: immunology.org/events/signal…
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🧬 New insight into rituximab resistance: CD40L and IL-4 shield B cells from NK cell-mediated killing via the HLA-E/NKG2A and HLA/KIR inhibitory pathways. Targeting these checkpoints could enhance B-cell depletion in autoimmune disease. 📖 doi.org/10.1093/cei/uxag001
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🧬 In a murine arthritis model, blockade of TIM-1 or TIM-3 reduced disease severity, inflammatory cytokines (IL-6, IL-17A, TNF-α), and joint damage, highlighting both receptors as promising therapeutic targets in rheumatoid arthritis. 📖 doi.org/10.1093/cei/uxae056
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Important CIDP research shows significant changes in circulating B‑cell subsets and elevated IL10/TNFA expression, correlating with disability scores and nerve fiber density. Valuable insights for understanding disease activity. 📄 doi.org/10.1093/cei/uxad103
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