Multicolor electron microscopy, time-resolved cryo-vitrification, single-molecule biology @Harvard MCB @MCB_Harvard and Applied Physics @hseas
Cambridge, MA
Joined July 2019
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Out today: Multicolor cathodoluminescence imaging of single lanthanide nanoparticles. You can shoot electrons at things and they will emit light that can be used for high-res imaging. But it's not easy! We show this using single lanthanide nanoparticles: nature.com/articles/s41467-0…
Max Prigozhin retweeted
A New Window into Protein Interactions at the Nanoscale @MaxPrigozhin @sohaib_ar @PNASNews @hseas @JeremyBConway @HarvardGSAS @RachelleGaudet @Harvard mcb.harvard.edu/department/n…
New pre-print! SMLM can detect intermolecular interactions, but how? We describe an algorithm that treats intermolecular interactions probabilistically to determine the absolute number of interacting molecules: biorxiv.org/content/10.1101/… Congrats Xingchi, Polly, Arvind and Sohaib!
We have an openning for a postdoctoral fellow interested in pursuing method development in cryo-vitrification (cryo-plunging and high-pressure freezing) for applications in studying nanoscale cellular organization using super-res imaging and cryo-ET. DM or e-mail me. Plz RT! 🔬🧊
Max Prigozhin retweeted
I’m super excited about the visit of my role model, Pietro! Not only have his contributions advanced our understanding of neuronal membrane biology, but he is also a wonderful mentor. His guidance has shaped the mentor I aspire to be for my trainees. 😊@PDClab @YaleCellBio
Pietro de Camilli to Present 2024 Konrad Bloch Lecture on April 1 @RachelleGaudet @VMurthyLab @PDClab @YaleMed @Harvard mcb.harvard.edu/department/n…
Inaugural Alma Dal Co @Alma_DalCo lecture delivered today by Uri Alon. This is the first time I saw a seminar speaker give a chalk talk. It actually worked pretty well. Would you try it?
Max Prigozhin retweeted
It cannot be done, they said.. It's too flexible, they said.. 😁
biorxiv.org/content/10.1101/… #NPC #teamtomo #integrativemodeling by @dgvjayS @neeleshsoni03 @JoshHutchings94 @ig_ech et al. Great collaboration w/ Qiang Guo, Brian Chait, Javi Fernandez-Mtnz, @RoutLab_RU @salilab_ucsf
Great talk today at @MCB_Harvard by Elçin Ünal from @berkeleyMCB about aging and rejuvenation of gametes in meiosis. The slide on the photo highlights the efforts of Elçin's former PhD student @JGoody1120, who was an UG student working with me at @ChemistryUIUC. Small world 🙂
Max Prigozhin retweeted
We updated our database of POSTDOC fellowships. We identified 316 different fellowships.
For each entry, we provide a link to the funder, amount, deadline, and eligibility criteria.
Download this free database here: research.jhu.edu/rdt/funding…
Max Prigozhin retweeted
New and improved way to generate difference maps, from my neighbors in the @HekstraLab ! Give it a try. :)
How a "Spot the Difference" Technique Illuminates the Wiggling of Proteins @HekstraLab @doeke_hekstra @JackGreisman @brooks_den29 @mklureza @Harvard @HarvardGSAS @PNASNews @UChicago mcb.harvard.edu/department/n…
Max Prigozhin retweeted
Interdisciplinary and Inter-Institutional Partnership Studying Neurodegenerative Diseases Wins Support from Chan Zuckerberg Initiative @JeeyunC @czi @cziscience @Harvard @synapsepark @RachelleGaudet mcb.harvard.edu/department/n…
Max Prigozhin retweeted
Thrilled to join the CZI neuroscience community together with @synapsepark ! Grateful for the support from @ChanZuckerberg for our team efforts to uncover the roles of brain lipid droplets!
We’re excited to support 64 interdisciplinary teams that are taking innovative approaches to study fundamental #neuroscience + neurodegenerative diseases. Read more about our second cycle of @ChanZuckerberg’s Neuroscience Collaborative Pairs Pilot Projects czi.co/42K4IqJ
Excited to give my talk about cathodophores for multicolor EM in 1 hr! Not sure who "Xiaowen Zhuang" is but they seem to be doing cool work... 🤷♂️
Very exciting to be at the BPS @BiophysicalSoc meeting is Philadelphia! The talks yesterday were wonderful. Looking forward to today!
Max Prigozhin retweeted
The authors “advocate for the value of learning and surprise, and for an irreverence for boundaries of all kind — between disciplines, science and technology”
This was the Bell Labs culture and became the guiding light for my own research!
nature.com/articles/s42254-0…
Looking forward to @BiophysicalSoc BPS2024 meeting in 1 month!
Check out who have been chosen as Symp Select Speakers for the upcoming @BiophysicalSoc meeting in Philadelphia!
biophysics.org/2024meeting/p…
Max Prigozhin retweeted
Happy holidays and a good resolution for 2024 🔬😀!
"It's not a goal that is the goal, it's actually the path towards the goal."
2014 chemistry laureate Stefan Hell shares his best career advice for young scientists and researchers.
#NobelPrize
Max Prigozhin retweeted
A #GPCR milestone from @m_madan_babu & @fmheydenreich, with Kobilka @stanford @Michel_Bouvier. Integrating pharmacological and structural data on beta2AR reveals the allosteric network that translates and decodes adrenaline binding into signaling response.
science.org/doi/10.1126/scie…
Max Prigozhin retweeted
Thrilled to see Mantis🦐🔬 💻, our new platform for high-throughput imaging and analysis of cell dynamics, in the wild. I am proud of and thankful to the team @czbiohub and @BoHuangLab 🙌.
Introducing Mantis, a two-in-one microscope designed at #CZBiohubSF that enables rapid high-dimensional imaging of molecular dynamics in the context of cell morphology. 🧵1/7
Preprint: ⬇️
biorxiv.org/content/10.1101/…
This is a pretty cool idea for signal amplification in fluorescence imaging: first fuse the target protein with a biotin ligase, then label with a fluorescent streptavidin:
Beyond BioID: Streptavidin outcompetes antibody fluorescence signals in protein localization and readily visualises targets evading immunofluorescence detection. biorxiv.org/cgi/content/shor… #bioRxiv