
The McDevitt lab studies bacterial pathogens, metals, transporters, and develops novel antibiotics. Based in @TheDohertyInst @UniMelb Lab head: @camcdevitt
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ALT The Hfe permease and Haemophilus influenzae manganese homeostasis. The Gram-negative bacterial pathogen Haemophilus influenzae use the manganese-recruiting protein HfeA to import the metal via the HfeBCD transporter into the bacterial cytoplasm. Here, contributes to protection against reactive oxidative species (ROS) stress as a cofactor in the manganese-superoxide dismutase (MnSOD). In a HfeA deficient strain, manganese cannot be transported by this pathway, resulting in loss of MnSOD activity and increased susceptibility to ROS stress.

ALT The Hfe permease and Haemophilus influenzae manganese homeostasis. The Gram-negative bacterial pathogen Haemophilus influenzae use the manganese-recruiting protein HfeA to import the metal via the HfeBCD transporter into the bacterial cytoplasm. Here, contributes to protection against reactive oxidative species (ROS) stress as a cofactor in the manganese-superoxide dismutase (MnSOD). In a HfeA deficient strain, manganese cannot be transported by this pathway, resulting in loss of MnSOD activity and increased susceptibility to ROS stress.


























