McGuire Lab (@McGuire_Lab) header
McGuire Lab (@McGuire_Lab) profile picture

McGuire Lab

@McGuire_Lab

We study the antibody response to natural infection with viral pathogens and use this information to design and test safe and effective vaccines.

Joined April 2018
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  • Following36
  • Followers428
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Photo by McGuire Lab (@McGuire_Lab)
Hello friends, our lab is looking for new team members. So if you are interested or know anyone who is please apply or share!!! careers-fhcrc.icims.com/jobs…
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Our new paper on EBV nanoparticle vaccines is now out in Cell Reports Medicine! cell.com/cell-reports-medici…
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Excited to share that our latest preprint is up on bioRxiv! biorxiv.org/content/10.1101/…
HSV-1 exploits host heterochromatin for egress

HSV-1 exploits host heterochromatin for egress

Herpes simplex virus replicates and forms progeny in the nucleus where it must overcome host chromatin to establish a successful infection. During lytic infection, newly formed viral capsids navigate...

biorxiv.org
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My Lab is #hiring We are looking for Research Technicians, Postdocs and a Staff Scientist to work on #vaccines for important human pathogens: #HIV-1, #EBV and #RSV at #FredHutch in #Seattle Apply here: research.fredhutch.org/mcgui…

Join our Lab

The McGuire Lab at Fred Hutch Cancer Center seeks enthusiastic, organized, and independent graduate students and post-doctoral research fellows who are interested in developing immunology, biochemi...

research.fredhutch.org
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Our new preprint is up where we show that a nanoparticle vaccine displaying the viral protein complex gH/gL protects humanized mice against lethal challenge with EBV. Great collaboration with the @KingLabIPD, @veeslerlab and others! biorxiv.org/content/10.1101/…
Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized...

Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized...

Epstein-Barr virus (EBV) is a cancer-associated pathogen responsible for 140,000 deaths per year. EBV is also the etiological agent of infectious mononucleosis and is associated with multiple...

biorxiv.org
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My Lab is #hiring We are looking for Research Technicians, Postdocs and a Staff Scientist to work on #vaccines for important human pathogens: #HIV-1, #EBV and #RSV at #FredHutch in #Seattle Apply here: research.fredhutch.org/mcgui…

Join our Lab

The McGuire Lab at Fred Hutch Cancer Center seeks enthusiastic, organized, and independent graduate students and post-doctoral research fellows who are interested in developing immunology, biochemi...

research.fredhutch.org
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McGuire Lab retweeted
Prlic Lab (@PrlicLab) profile picture
Prlic Lab@PrlicLab2 Feb 2022
Identical and nearly identical T cell receptors on CMV-specific donor and recipient-derived T cells (incl. CDR3!) in transplant patients. A great collaboration led by Jami Erickson with Phil Bradley and Michael Boeckh, all @fredhutch pnas.org/content/119/6/e2117…
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Check out our new pre-print: Structural definition of a pan-sarbecovirus neutralizing epitope on the spike S2 subunit biorxiv.org/content/10.1101/…
Structural definition of a pan-sarbecovirus neutralizing epitope on the spike S2 subunit

Structural definition of a pan-sarbecovirus neutralizing epitope on the spike S2 subunit

Three highly pathogenic betacoronaviruses have crossed the species barrier and established human-to-human transmission causing significant morbidity and mortality in the past 20 years. The most...

biorxiv.org
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Staff Scientist, McGuire Lab (#Seattle, Washington) #job We are looking Staff Scientist to assist with the development, validation, and testing of novel vaccine candidates aimed at preventing infection by viruses of global health importance. social.icims.com/viewjob/pt1…
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Huge congrats to our rockstar undergrad Irika who won the Dean's Medal for Natural Sciences from the UW College of Arts and Science!!! chem.washington.edu/news/202…
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I'm excited to share our study demonstrating a largely shared immune landscape between patients hospitalized with SARS-CoV-2 versus other respiratory viruses, Flu or RSV. medrxiv.org/content/10.1101/…
A differential regulatory T cell signature distinguishes the immune landscape of COVID-19 hospita...

A differential regulatory T cell signature distinguishes the immune landscape of COVID-19 hospita...

SARS-CoV-2 infection has caused a lasting global pandemic costing millions of lives and untold additional costs. Understanding the immune response to SARS-CoV-2 has been one of the main challenges in...

medrxiv.org
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Our study examining recall responses in recovered SARS-CoV-2+ donors elicited by mRNA vaccines, and their ability to neutralize B1.351 and SARS-CoV-2 with @StamatatosL and the McElrath Lab is now out in Science. science.sciencemag.org/conte…
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New pre-print is up describing some new cross-neutralizing SARS-CoV-2 antibodies from @StamatatosL @SutharLab @WardLab1 @HelenChuMD and others. biorxiv.org/content/10.1101/…
Isolation and Characterization of Cross-Neutralizing Coronavirus Antibodies from COVID-19+ Subjects

Isolation and Characterization of Cross-Neutralizing Coronavirus Antibodies from COVID-19+ Subjects

SARS-CoV-2 is one of three coronaviruses that have crossed the animal-to-human barrier in the past two decades. The development of a universal human coronavirus vaccine could prevent future pandemi...

biorxiv.org
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A new study with our friends from Montreal. A single BNT162b2 mRNA dose elicits antibodies with Fc-mediated effector functions and boost pre-existing humoral and T cell responses biorxiv.org/content/10.1101/…
A single BNT162b2 mRNA dose elicits antibodies with Fc-mediated effector functions and boost...

A single BNT162b2 mRNA dose elicits antibodies with Fc-mediated effector functions and boost...

The standard dosing of the Pfizer/BioNTech BNT162b2 mRNA vaccine validated in clinical trials includes two doses administered three weeks apart. While the decision by some public health authorities...

biorxiv.org
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Happy #InternationalWomensDay to all the fantastic women that I'm fortunate enough to work with!
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We are looking to hire a Post-Doctoral Research Fellow, to work on HIV-1 vaccines with dash of SARS-CoV-2 work ! #job social.icims.com/viewjob/pt1…
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We're looking for a Staff Scientist, to work on HIV-1 Vaccine Development . #job social.icims.com/viewjob/pt1…
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Our new preprint is out. We found that a single shot of the current COVID-19 vaccines boost the neutralizing antibody response in people who were previously infected, and that these antibodies have neutralizing activity against B.1.351 and SARS-1. medrxiv.org/content/10.1101/…
Antibodies elicited by SARS-CoV-2 infection and boosted by vaccination neutralize an emerging...

Antibodies elicited by SARS-CoV-2 infection and boosted by vaccination neutralize an emerging...

The emergence of SARS-CoV-2 variants raises concerns about their resistance to neutralizing antibodies elicited from previous infection, or from vaccination. Here we examined whether sera and...

medrxiv.org
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McGuire Lab retweeted
King Lab (@KingLabIPD) profile picture
King Lab
@KingLabIPD27 Jan 2021
It's a historic day for the lab: Our candidate nanoparticle #SARSCoV2 vaccine has been injected into humans — the first in-person test of our immunogen design platform. Thanks to SK Bioscience 🇰🇷 for leading this Phase 1 trial. cell.com/cell/fulltext/S0092…
Image from King Lab (@KingLabIPD)
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A team led by Drs. Marie Pancera, @McGuire_Lab and @StamatatosL have shown that a potent antibody interferes with a key feature on the surface of the #coronavirus’s distinctive spikes and induces critical pieces of those spikes to break off in the process. bit.ly/34CTw2R
Scientists map structure of potent antibody against coronavirus

Scientists map structure of potent antibody against coronavirus

Structural biologists at Fred Hutch have created 3D images that show how a potent antibody from a COVID-19 survivor interferes with a key feature on the surface of the coronavirus’s distinctive...

fredhutch.org
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