@MelanderLab

Antibiotic adjuvants, biofilms and all things bacterial resistance | student run

 University of Notre Dame
sites.nd.edu/melanderlab/research/
Joined February 2020
  • Tweets45
  • Following122
  • Followers107
9Media
Melander Lab retweeted
OBC@OrgBiomolChem28 Apr 2023
Alexander Horswill @Horswill_Lab, Christian Melander @MelanderLab & co @CUAMCImmu_micro @NDscience report a structure activity relationship study of 3,4′-dimethoxyflavone for Staphylococcus aureus ArlRS inhibition in our latest issue Read the paper here🔽 pubs.rsc.org/en/content/arti…

A structure activity relationship study of 3,4′-dimethoxyflavone for ArlRS inhibition in Staphylo...

Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are difficult to treat due to their resistance to many β-lactam antibiotics, and th

pubs.rsc.org
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Congratulations to Annie and Ansley! Overcoming intrinsic resistance in gram-negative bacteria using small ... sciencedirect.com/science/ar…
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Congrats Haoting and everyone who contributed! 6-Bromoindirubin-3′-oxime derivatives are highly active colistin adjuvants against Klebsiella pneumoniae - now published in RSC Medicinal Chemistry pubs.rsc.org/en/content/arti…

6-Bromoindirubin-3′-oxime derivatives are highly active colistin adjuvants against Klebsiella...

Multidrug resistant (MDR) bacterial infections have become increasingly common, leading clinicians to rely on last-resort antibiotics such as colistin. How

pubs.rsc.org
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Great job Ansley! Highlighting the 2020–2021 ACS Division of Medicinal Chemistry Award Winners pubs.acs.org/doi/10.1021/acs…

Highlighting the 2020–2021 ACS Division of Medicinal Chemistry Award Winners

The ACS Division of Medicinal Chemistry (MEDI) is delighted to announce the winners of the 2020–2021 division awards (Figure 1). These awards acknowledge t

pubs.acs.org
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Development of small molecules that work cooperatively with ciprofloxa... sciencedirect.com/science/ar… Congratulations Katie and everyone who contributed!!
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Synthesis, Stereochemical Confirmation, and Derivatization of a Clerodane Diterpene That Sensitizes Methicillin‐Resistant Staphylococcus aureus to β‐Lactam Antibiotics onlinelibrary.wiley.com/doi/… Congratulations Michael and everyone who contributed!! @QuaveEthnobot

Synthesis, Stereochemical Confirmation, and Derivatization of 12(S),16ϵ‐Dihydroxycleroda‐3,13‐die...

The synthesis of a diterpene natural product that potentiates the activity of β-lactam antibiotics against methicillin-resistant Staphylococcus aureus, and its stereochemical confirmation via X-ray...

onlinelibrary.wiley.com
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We are so happy to have our rising fourth year, @ansleynemeth, back from her 5 week internship in Boston! She was working with Dr. Eddie Geisinger at Northeastern University. She was primarily working on Tn-seq with some of the compounds she synthesized.
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Congratulations @ansleynemeth! Looking forward to recognizing the great work of our fellowship awardees!
Melander Lab@MelanderLab19 Apr 2021
Congratulations to our student @ansleynemeth for receiving the @AcsMedi predoctoral fellowship! Thanks to ACS MEDI Division and @genentech for sponsoring this award. We are excited for Ansley for this opportunity!
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Congratulations to our student @ansleynemeth for receiving the @AcsMedi predoctoral fellowship! Thanks to ACS MEDI Division and @genentech for sponsoring this award. We are excited for Ansley for this opportunity!
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Melander Lab 2021 coming at you live! #NewProfilePic
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Congratulations to Dr. Karlie Cox for successfully defending her thesis!
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A beautiful column being run by one of our second years! We hope she gets a pure product!
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Melander Lab retweeted
Bill Wuest@wmwuest27 Jan 2021
Congrats to @AnaCheng06 of the @Wuestlab for making the most of the quarantine & writing a book! Thanks to @ACSPublications for inviting us to write the inFocus book Antibiotics intended to be a 5-hr course for senior UGs/1st yr grads. @laneygradschool pubs.acs.org/doi/10.1021/acs…
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COVID patients and A. baumannii. Wish I could say I am surprised. But I am not. Increase in Hospital-Acquired Carbapenem-Resistant ... cdc.gov/mmwr/volumes/69/wr/m… via @CDCgov

Increase in Hospital-Acquired Carbapenem-Resistant ...

This report describes a cluster of 34 carbapenem-resistant Acinetobacter baumannii cases in a New Jersey hospital that peaked during a surge in COVID-19 hospitalizations.

cdc.gov
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Latest paper from the lab. Congrats Alex, Sam, Pat and Orry! Thanks to @ErnstLabUMB A scaffold hopping strategy to generate new aryl-2-amino pyrimidine MRSA biofilm inhibitors - now published in RSC Medicinal Chemistry pubs.rsc.org/en/content/arti…

A scaffold hopping strategy to generate new aryl-2-amino pyrimidine MRSA biofilm inhibitors†

Infections that stem from bacterial biofilms are difficult to eradicate. Within a biofilm state, bacteria are upwards of 1000-fold more resistant to conven

pubs.rsc.org
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Melander Lab retweeted
CAIN@cain_amr18 Nov 2020
"Antibiotic Resistance: A Matter of Time." Kick off World Antimicrobial Awareness Week 2020 with this powerful video from @FT. ft.com/video/7712f728-76e1-4…

Antibiotic resistance: a matter of time

In the future even cuts can have fatal consequences, with drug resistant infections killing 10m people a year. Is this just a projection? The FT travels through time with artist Nina Dunn to see how...

ft.com
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Two papers from the lab included in this collection!
ChemMedChem@ChemMedChem5 Nov 2020
To recognize the WHO's World Antimicrobials Awareness Week (18-24.Nov #WAAW2020), our Hot Topic this month is #Antimicrobials, free to read for the rest of the year: bit.ly/cmc-2020-Antimicrobia… #drugdiscovery #medchem
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To all of my #antibiotic discovery peeps interested in #naturalproducts -- I'd love to brainstorm ways to leverage this work to fill the #antibiotic pipeline with more #plantbased scaffolds! #chemicalbiology @MelanderLab @whiteleylab @DaZtrain @gerryiidr @eric_brown_bbs + more🌺
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New paper from #QuaveLab!! I'm so proud of this one! Our team worked tirelessly on this for >1 year to undertake the 1st major assessment of antibiotic compounds from plants! Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery pubs.acs.org/doi/10.1021/acs…

Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery

Abstract. The crisis of antibiotic resistance necessitates creative and innovative approaches, from chemical identification and analysis to the assessment

pubs.acs.org
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Call for papers on Antibacterial Drug Discovery. Click here for more information: ow.ly/rA8M50CbIEE
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