@Mezarque

Cofounder of @dittobio, @ycombinator (W26) | prev: @berkeleyMCB @hscrb

 Ohlone Land (Berkeley, CA)
dennisasun.com
Joined January 2012
  • Tweets1.3K
  • Following464
  • Followers1.5K
236Media
Dennis Sun retweeted
Vaibhav
@vaibagraJun 10
We’re launching @trybaseframe to take you from AI fatigued to AI native. You already have the AI tools. What you don't have is the time to figure out what to actually do with them, which features are useful to you, and how to use them. BaseFrame does that for you. Its desktop app finds the repetitive work eating your week that you could automate today with the AI tools you already have. Download the app and start unlocking hours today. Link below:
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The genomics revolution told us which genes cause disease. What if small molecules could target the genetic message? CRISPR-level precision, in a pill. Endura Insights #1: why the genomics revolution is only half finished. enduratx.com/blog/the-genomi…
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Dennis Sun retweeted
Adair@AdairLBorgesMar 4
Finally got around to writing up some of our progress at @dittobio ! Check out our inaugural blog post to learn how my favorite parasites (aka viruses 😎) can improve target selection and discover blockbuster drug mechanisms for autoimmune disease: dittobio.com/blog/2025-03-02…

Mapping parasite molecules to treat autoimmune disease | Ditto Bio

How we use parasite biology and our MoleculeMapper platform to improve target selection for autoimmune disease — including a viral molecule that invented the same mechanism as a blockbuster drug.

dittobio.com
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Dennis Sun retweeted
Adair@AdairLBorgesFeb 13
I met @zoink aka the @figma CEO at a @ycombinator event. Yes I told him all about ticks🩸
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The world's best immunologists live inside you 👀🦠🪱 🚀 Watch our launch video to learn more! Thanks to everyone who's believed in @dittobio, especially @agupta @ycombinator !
Y Combinator
@ycombinatorFeb 9
.@dittobio discovers drugs for autoimmune diseases by harnessing parasite biology. Viruses, ticks, and worms have experimented over millions of years to create proteins that control the human immune system. Ditto Bio is using AI to identify these natural, drug-like proteins and engineer them into next-generation autoimmune therapies. Congrats on the launch @AdairLBorges, @Mezarque, and @emilycpierce! ycombinator.com/launches/PNb…
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Dennis Sun retweeted
Fondo.com
@FondocomFeb 9
🚀 @dittobio launched! Evolutionary Therapies for Autoimmune Disease “Ditto Bio discovers new drugs by harnessing parasite biology.” 🌐 fondo.ai/3ZrLsNN Congrats @AdairLBorges @Mezarque @emilycpierce!!

Ditto Bio Launches: Evolutionary Therapies for Autoimmune Disease | Fondo

Ditto Bio Launches: Evolutionary Therapies for Autoimmune Disease

fondo.com
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Dennis Sun retweeted
Adair@AdairLBorgesFeb 9
POV: You convince your friends to quit their jobs and turn parasite proteins into drugs 💊 Thanks @ycombinator for betting on our team! 🪱🦠👾
Y Combinator
@ycombinatorFeb 9
.@dittobio discovers drugs for autoimmune diseases by harnessing parasite biology. Viruses, ticks, and worms have experimented over millions of years to create proteins that control the human immune system. Ditto Bio is using AI to identify these natural, drug-like proteins and engineer them into next-generation autoimmune therapies. Congrats on the launch @AdairLBorges, @Mezarque, and @emilycpierce! ycombinator.com/launches/PNb…
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Last year, I cofounded @dittobio with two exceptional scientists and friends @AdairLBorges @Mezarque. We turn parasite molecules into drugs for autoimmune disease 💊🪱 Excited to announce we are now backed by @ycombinator! Huge thanks to @agupta for betting on us 🙏 🔗below
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Dennis Sun retweeted
Adair@AdairLBorgesFeb 7
Inaugural post! (after a long hiatus) Last May I quit my job to build @dittobio with @Mezarque and @emilycpierce ! We turn parasite molecules into drugs for autoimmune disease, and are part of the @ycombinator W26 batch. Thanks for betting on us @agupta
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Happy Darwin Day! Today we’re thinking about how to use evolution to accelerate biomedical research. We think the answer is to expand the repertoire of organismal models. Search for the best ones using our new portal Zoogle: zoogle.arcadiascience.com/ab… 🧵
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Srinivasan has posted responses to our manuscript documenting data duplication in his papers. They are filled with insults, and all instances of identical data are dismissed as "typographical errors." You can find his responses and our thoughts here: github.com/pachterlab/LP_202… 🧵

LP_2024/response_to_rebuttal.pdf at main · pachterlab/LP_2024

Contribute to pachterlab/LP_2024 development by creating an account on GitHub.

github.com
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Join the discussion of our latest review at @askalphaxiv. Check out the great comment (by @Mezarque / @ArcadiaScience) — and our response — about the extension of these computational strategies to non-traditional #ModelOrganisms.
Arjun Krishnan@compbiologist29 Aug 2024
Preprint 🚨 A review state-of-the-art computational strategies for cross-species knowledge transfer in biomedicine 💻👩‍🦰🐭🐟🪰🪱🧬🫁⚕️ Led by an excellent team at @KrishnanLab: @yhbioinfo, @ChrisAMancuso, & @kaylainbio in collab w/ @FishEvoDevoGeno 🧵 arxiv.org/abs/2408.08503

Computational strategies for cross-species knowledge transfer

Research organisms provide invaluable insights into human biology and diseases, serving as essential tools for functional experiments, disease modeling, and drug testing. However, evolutionary...

arxiv.org
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If you’re a fan of DIY lab equipment, you’ll love the phenotype-o-mat, a customizable DIY 96-well plate imager from @ArcadiaScience that you can now build for only $400 🧵 1/7 protocols.io/view/building-a…
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At @ArcadiaScience we also share our negative results. Dive into our latest work where we employed trait mapping and evolutionary analysis in search of the function of a structurally divergent actin isoform in fungi. Discover more in our thread 🧵 [1/8] research.arcadiascience.com/…
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Can we identify more human-relevant and research-friendly models by unifying various genetic approaches? Join us at #TAGC24 to hear about our approach to integrating genetics and comparative methods to predict drivers of biological innovation! tagc2024.arcadiascience.com
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How might structural differences within the actin family lead to insights about its proteins’ functions? I’m excited to share how we @ArcadiaScience evaluated the #ProteinCartography pipeline and generated new hypotheses about the actin family! 🧵[1/4] research.arcadiascience.com/…
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🚨 An updated version (v0.4.2) of the #ProteinCartography pipeline (our tool for protein comparisons across species) is now available: github.com/Arcadia-Science/P…

Release v0.4.2 · Arcadia-Science/ProteinCartography

ProteinCartography v0.4.2 Overview This release introduces minor changes that improve the performance of the pipeline. These changes are not breaking changes and do not modify the nature of the fil...

github.com
Dennis Sun@Mezarque29 Sep 2023
Replying to @Mezarque
The pipeline wraps results into interactive HTML files, which you can use to explore the protein-to-protein differences in taxonomic origin, length, structure quality, and more. 🌐 3/9
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In our new pub, we investigate disease-associated repeat expansions (dREs). Expansion of DNA repeats can cause neurodegeneration, as in Huntington’s disease. We looked for dREs across the tree of life, and found them in surprising, and cute, places!🧵1/7 arcadia-research.pubpub.org/…
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If you’re attending #CellBio2023, don’t forget to send your favorite proteins (submit on ascb2023.arcadiascience.com)! Then, come see me and @arcadiascience at booth #434 to check out an interactive structure-based map generated by ProteinCartographyand to chat about our other work!

Protected Deployment – Vercel

vercel.com
Brae M Bigge@BiggeBrae17 Nov 2023
Excited for ASCB #CellBio2023? @ArcadiaScience and the Functional Annotation team are! We’ll be bringing along ProteinCartography and giving you a chance to interact with a comparative structure-based map of your favorite protein! bit.ly/protein-cartography 🧪 [1/3]
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We’re heading to #cellbio2023! Check out ascb2023.arcadiascience.com to see the posters we’re presenting and what else we’ll be up to. But keep reading — we want to hear from you! 👇 1/3
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