
Postdoctoral researcher at @JohnsHopkinsSPH ; Neuroscientist ; Computational Biology. Person who stutters; Opinions are my own
Baltimore, MD
Joined September 2009
- Tweets5.6K
- Following1.5K
- Followers1.3K
- Likes18.6K
Pinned Tweet
Incredibly proud to share our newest work where we developed a multiscale spatial transcriptomic atlas of the human amygdala using three complementary technologies! 1/12 🧵 biorxiv.org/content/10.64898…
Michael Totty retweeted
Discovery often comes from putting familiar pieces in unexpected ways: but bio space is too vast to do that effectively?
🤖 1000s of AI agents helped connect our whole-brain Perturb-seq atlas w literature. w @OpenAI @joyjiao12: more coming! See preprint biorxiv.org/content/10.64898…
GPT-Rosalind surfaced a new lead for drug discovery: could restoring cholesterol transport protect neurons from degeneration?
DCTN1 is a gene linked to Perry syndrome, a rare neurodegenerative disorder. In mouse-brain data, disrupting it increased expression of genes involved in making cholesterol. GPT-Rosalind suggested a possible explanation: cholesterol may not be reaching where neurons need it.
That gives scientists a specific mechanism to test and, if confirmed, a direction for developing new treatments for neurodegenerative disorders.
With @perturbai_tx and @scrippsresearch, a team of thousands of GPT-Rosalind agents worked in parallel, connecting gene-expression results from millions of mouse brain cells with scientific literature in just 32 minutes. We’re now expanding this collaboration to identify new drug targets.
openai.com/index/scaling-ai-…
Michael Totty retweeted
Congratulations to our first #NobelPrize laureate of 2026 🎉
Early this morning Karl Deisseroth found out he was awarded this year's Nobel Prize in Physiology or Medicine.
He seems very happy with the news!
It's a bit of a buzz kill seeing a $500k cancer research donation happen on College Gameday and knowing it's probably going to fund a single 'omic experiment.
Michael Totty retweeted
My department is hiring! Come join a vibrant and thriving neuroscience group. New faculty are exceptionally well supported and we offer a very collaborative/collegial environment. employment.utah.edu/salt-lak…
We also developed web-based apps for exploring each of these datasets freely on your browser! I'm a big fan, so please check them out! You can find them along with the analysis and links to raw data files on the landing page for our github repo. 11/12 github.com/LieberInstitute/s…
Michael Totty retweeted
CIGMA is out in Nature — A linear mixed model to unbiasedly characterize cell-type-specific eQTLs. Work advised by @andywdahl and a lot of help from @xinpei_w
nature.com/articles/s41586-0…











