@MikaelScience

Scientist in @TheBlanchardLab. I like ribosomes.

Joined May 2020
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  • Following150
  • Followers47
Excited to share our Annual Reviews in Biophysics article on Single-Molecule Imaging of Integral Membrane Protein Dynamics and Function. Many thanks to all authors for their diligence putting this summary overview together! pubmed.ncbi.nlm.nih.gov/3901…
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Out today from the Blanchard lab! An important paper showing that the accuracy of smFRET measurements depends on excitation strength, and how to correct for these issues or bypass them with self-healing dyes. nature.com/articles/s41592-0…
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» Ribosome-binding antibiotics increase bacterial longevity and growth efficiency | PNAS pnas.org/doi/abs/10.1073/pna…

Ribosome-binding antibiotics increase bacterial longevity and growth efficiency | PNAS

Antibiotics, by definition, reduce bacterial growth rates in optimal culture conditions; however, the real-world environments bacteria inhabit see ...

pnas.org
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High resolution Molecular dynamics (MD) of mRNA translation on ribosome
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Vasili Hauryliuk@hauryliuk9 Aug 2023
It is out in @PNASNews. A massive bioinformatics undertaking by @gem__atkinson lab + an insane amount of experiments from my team and numerous collaborators. The first new phage defence system from Lund! @HenrikStrahl @arneelof @KarinErnits @FacultyLund pnas.org/doi/10.1073/pnas.23…

The structural basis of hyperpromiscuity in a core combinatorial network of type II toxin–antitoxin...

Toxin-antitoxin (TA) systems are a large group of small genetic modules found in prokaryotes and their mobile genetic elements. Type II TAs are enc...

pnas.org
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Happy to share that Mathew Gagnon and my lab's joint story of translation inhibition by aminoglycoside Amikacin is now published in @NatureComms 🥳🥳🥳. Superhappy for this collaboration. Fast-kinetics biochemistry and structure together make a very powerful tool afterall 😃
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Our study shows that ribosomal genes—widely used to infer the origin of species—also hold a record of the optimal growth conditions for a given species, making it easier to infer the optimal environment for uncultured or extinct organisms (1/3): academic.oup.com/nar/article…
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check out our Spotlight Article @TrendsGenetics 🔥 hot 🔥 off the press! teamed up with @OlivierDuss (@EMBLHeidelberg) & @RainerNikolay (@MPI_MolGen) to cover the recent mRNA decoding ribosome smFRET🤝cryoEM story from @TheBlanchardLab open access 👇 authors.elsevier.com/a/1hJjv…
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Olivier Duss@OlivierDuss26 Jun 2023
In our new Spotlight in @TrendsGenetics we are discussing the recent @Nature paper from @TheBlanchardLab about eukaryotic mRNA decoding combining smFRET and cryoEM! Was fun to collaborate with & @MatthewKraushar & @RainerNikolay @MPI_MolGen on this! sciencedirect.com/science/ar…
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We suffered two problems on our Krios/Arctica instruments related to a pressure gauge called PPal. Here a picture of the faulty PPal from the Arctica. But then...what is a PPal and how it measures pressure? These two questions kept me busy for a while, a thread to follow 👇
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Very soon and thanks to one an only @delarosatrevin an integrated solution for CryoEM facility management and on-the-fly processing with Cryolo/ctfffind/Relion ! And free!!! 👇🏽 Look at these gorgeous ribosome from @TheBlanchardLab !
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Ignatova Lab@IgnatovaLab31 May 2023
Happy to anounce our paper published today ⁦@Nature⁩ - a tour-de-force in tRNA biology. We developed suppressor tRNAs with high efficieny in correcting PTCs. For a disease protein we crossed a disease threshold of correction. #cftr #uhh nature.com/articles/s41586-0…

Engineered tRNAs suppress nonsense mutations in cells and in vivo

Nature - Suppressor tRNAs adapted to the amino acid that they carry enable readthrough of premature termination codons introduced by nonsense mutations and show potential for the treatment of...

nature.com
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alexmag@AlexmagCryo15 Apr 2023
Proud to be involved in this work. Please have a look. High res.80S ribosome, many states, interesting story. @TheBlanchardLab @AlexmagCryo @KundhavaiS nature.com/articles/s41586-0…

mRNA decoding in human is kinetically and structurally distinct from bacteria

Nature - The reaction coordinate of aminoacyl-tRNA movement is altered on the human ribosome and the process is an order of magnitude slower compared with bacteria due to eukaryote-specific...

nature.com
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News Medical@NewsMedical7 Apr 2023
Is mRNA decoding in humans structurally and kinetically distinct from bacteria? news-medical.net/news/202304… @Nature @StJudeResearch #mRNA #bacteria #molecularbiology #research #bacteria #microbiology #cells #news
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Mechanism of messenger-RNA decoding in humans illuminated nature.com/articles/d41586-0…

Mechanism of messenger-RNA decoding in humans illuminated

Nature - Key differences identified in the structure and function of human ribosomes compared with those of bacteria.

nature.com
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See also Research Briefing here: nature.com/articles/d41586-0… Congrats @TheBlanchardLab @MikaelScience @ERundlet @KundhavaiS and all authors!
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Now #OA @Nature: combining #cryoEM and #smFRET to examine decoding by human #ribosome, @TheBlanchardLab reveals important differences from bacterial ribosome and mechanisms of action of several translation inhibitors. nature.com/articles/s41586-0…
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Human ribosomes decode messenger RNA 10 times slower than bacterial ribosomes—but do so more accurately. Explore how St. Jude scientists made this discovery. bit.ly/3zxa9v8 @TheBlanchardLab @nature #cryoEM
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DNA to RNA real-time speed. Gene Transcription at real-time speed. Transcription is the first step in gene expression.
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Slava Bobrov
@slava__bobrov4 Nov 2022
An MRI of what it looks like when you rub your eyes: #biology by D. Gatinel
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