Offensive Security | Global Entrepreneur
Joined November 2010
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Mike Gropp retweeted
Americans are being threatened by foreign countries with arrest and imprisonment for exercising their First Amendment rights online.
The federal GRANITE Act, H.R. 10174/S. 5478, would fix this and deter foreign censorship. Call your representatives!
Mike Gropp retweeted
Right. Dario was already claiming that GPT2 was too dangerous to open source back in 2019.
I made fun of them then.
Everyone should make fun of them now.
Mike Gropp retweeted
Heading across the river tomorrow for the Harvard Systems Biology Seminar at noon. I'll definitely discuss this paper and some nifty unpublished things. hope to see folks there!
@harvardmed @HMS_SynBioHIVE @HMS_SysBio @baym @NoahOlsman
Could the folding of synthetic gene circuits in 3D shape how genes are expressed? Today @ScienceMagazine we report on the role of gene syntax in shaping feedback between transcriptional activity and genome folding for advanced circuit design🧵 (1/n)
Mike Gropp retweeted
I reread this every year.
I cry like a baby every year.
Todd Beamer died a father, husband, and hero.
Todd: Hello… Operator… listen to me. I can’t speak very loud. This is an emergency. I’m a passenger on a United flight to San Francisco. Our plane has been hijacked.
Lisa: I understand. Can they see you?
Todd: No. There are three that we know of. They have knives — razor knives, like box cutters. Someone announced from the cockpit there was a bomb. It sounded fake.
Lisa: Your name?Todd: Todd Beamer. United Flight 93.Todd: They killed one passenger in first class. They forced most of us back. Fourteen of us here. Five flight attendants. The guy with the bomb ordered us to sit on the floor.
Lisa: Are you okay?
Todd: We’re going down… wait. No. We’re leveling off. We changed directions. We’re flying east again.
Todd: A guy named Jeremy called his wife. She told him two planes hit the World Trade Center. Lisa, is that true?
Lisa: I have to tell you the truth. It’s very bad. Both towers are gone. A third plane hit the Pentagon. Our country is under attack. I’m afraid your plane may be part of their plan.
Todd: Oh God. Lisa, will you do something for me? Call my wife and my kids. Promise me you’ll call.
Lisa: I promise.
Todd: Our home number is… You have the same name as my wife. Lisa. We’ve been married ten years. She’s pregnant with our third child. Tell her I love her. I’ll always love her. We have two boys — David, he’s 3, and Andrew, he’s 1. Tell them their daddy loves them and he is so proud of them. The baby is due January 12th. I saw an ultrasound. We still don’t know if it’s a girl or a boy.
Lisa: I’ll tell them. I promise, Todd.(Lisa patches in the FBI.)
Agent: Todd, your plane is on a course for Washington. Best guess is the White House or the Capitol.
Todd: I understand. I’ll be back.
Todd: Everyone knows this isn’t a normal hijacking. We have decided we will not be pawns in their plot.
Lisa: What are you going to do?
Todd: Four of us are going to rush the one with the bomb. Then the cockpit. A stewardess is getting boiling water. We’ll take them out.
Todd: Would you pray with me?They pray the Lord’s Prayer. Then: Yea, though I walk through the valley of the shadow of death, I will fear no evil, for thou art with me.
Todd: God help me. Jesus help me.Are you guys ready? Let’s Roll.
Mike Gropp retweeted
The biotech era debuted in the 1980s, and this is the type of lab the NIH thought a single R01 could support.
Using the NIH entry-level postdoctoral stipend as a consistent benchmark, a single R01 with $250,000 in annual direct costs could theoretically pay for about 15.6 postdoc-years in 1987, when the stipend was $15,996 per year.
How about today? At the FY2026 stipend of $63,480 per year, that same $250,000 would pay for only about 3.9 postdoc-years.
This means that while a single R01 could theoretically support the equivalent of about 3 entry-level postdocs over 5 years in 1987, it could support fewer than one (one for four years) today—a roughly 75% loss in personnel purchasing power.
And, of course, this assumes that every dollar goes directly to postdoc stipends. It does not include fringe benefits, PI salary, graduate students, technicians, supplies, equipment, animals, core-facility fees, travel, publication charges, or any of the other costs required to run a modern laboratory.
Same nominal R01. Roughly one-quarter of the scientific labor.
The Simpsons debuted in 1987 and this is the type of house the shows creators thought a single-income family could afford.
According to an episode in Season 1, Homer made 25k a year(60k in 2026 dollars).
In 1987 that house would cost about 100k(which was the national average) with a mortgage of roughly $700/month(assuming 20% down and interest rates consistent with that time)
How about today? The same house would cost 450k with a mortgage of roughly $2,500/month.
This means that while Homer was spending ~30% of his income on his mortgage in 1987 he would need to spend closer to 50% of his income on his mortgage today.
And of course, this doesn't include other areas of inflation such as food, gas or etc.
Mike Gropp retweeted
Programmable Coins (my article for This Week In Chia's Chia Toronto 2026 special edition) open.substack.com/pub/fireac…
Mike Gropp retweeted
The Galloway Lab is at the American Society of Gene & Cell Therapy Annual Meeting. Come check out our new work in building genetic controllers, optimizing lenti design, and titrating cell-fate regulators to optimize scalable production of neurons. Hope to see you at the meeting! #ASGCT2026.
Details below 👇
Tuesday May 12th Poster session at 5:00PM-6:30PM
Kasey Love @kaseyslove
"Engineering high-titer lentiviral vectors for robust expression of RNA-based gene circuits"
Abstract ID: 1067
Derin Gumustop and Paulina Naydenkov
"Single-transcript, microRNA-based incoherent feedforward loop delivers precise transgene expression in primary cells"
Abstract ID: 1067
Thursday May 14th Poster session at 5:00PM-6:30PM
Brittany Lende-Dorn
"Chemogenetic tuning reveals optimal MAPK signaling for cell-fate programming"
Abstract ID: 3467
Mike Gropp retweeted
Built a thing I’ve wanted forever… a way to let my kids access YouTube content I like without getting exposed to the algo and becoming zombies 😵
My @openclaw friends are the dev team this is barefoot housewife has always dreamed of 🙏😂❤️
YouTube stream curated by us, no slop
Mike Gropp retweeted
Simply evil.
They would like to destroy the economy, let in infinite criminals, erode your right to vote and to private property, rather than not be in power.
This is not empathy, this is pure sabotage and destruction of American principles for selfish gain of power.
Mike Gropp retweeted
Exciting news: I’ve decided to move into Billie Eilish’s $6 million Malibu beachfront mansion because no human being is illegal on stolen land.
Thank you Billie for your generosity.
Mike Gropp retweeted
Incredible.
This is the DNA Repair System. Look how many parts work together to make the system function.
Without DNA Repair, mutations in DNA would completely destroy its functionality very quickly - it would degrade rapidly into non-functional junk. Which means, the DNA Repair System would have to have been around since the very beginning of Life; DNA and the Repair Systems would have to arise together, at the same time, or DNA could not survive - and neither could Life.
But how complex is the DNA Repair System?
It requires 6-7 major systems, working in coordination together. Combined, those systems contain a total of about 130-200+ total unique proteins that make up the systems to do the job.
Two things make this system most likely designed:
1. DNA cannot survive without DNA Repair. The entire system must be in place at the very start of Life, or Life never starts. But creating the systems requires the information in DNA - they both must arise together, simultaneously.
2. The specified, irreducible complexity of the system. DNA Repair requires a minimal amount of specifically engineered protein systems to function. Just look at how many separate systems are involved in that process!
How can anyone see something like this and believe it arose by an accident of natural processes?
Life is so clearly intelligently Created.
Mike Gropp retweeted
Israel can't get into your phone that's running @GrapheneOS 👇
"Leaked documentation from Cellebrite, the Israeli forensics company serving 7,000 law enforcement customers worldwide, reveals that every major Android manufacturer's devices can be exploited in both locked and unlocked states. Every Samsung, every OnePlus, every Motorola. The one exception, explicitly marked as inaccessible in their internal documentation, is GrapheneOS running on Pixel hardware with patches from late 2022 onward. A whistleblower who joined a private Cellebrite training session in October 2024 reported that every locked Pixel 9 running GrapheneOS was listed as beyond their capabilities."
"The device in your pocket is not yours. You paid for it, certainly. You carry it everywhere, sleep beside it, and entrust it with your most private communications. But in every meaningful sense, it belongs to someone else. It reports your location to Google every 4.5 minutes. It transmits approximately one megabyte of telemetry every twelve hours while sitting idle on your nightstand. It does this even when you navigate endless settings menus and explicitly opt out. The opt-out is theater. The surveillance is the product."
Mike Gropp retweeted
Lock in!!
This and other courses are part of the Library Access.
pyjamacafe.com/library/#c
Save 70%. Use code HAPPY2026 at the checkout!
Mike Gropp retweeted
As a response to socialism, Miami will replace NYC as the finance capital and Austin will replace SF as the tech capital.
Mike Gropp retweeted
Delighted to end the year with some highlights including a new PhD!
Congrats, Dr Christopher Johnstone! Amazing work! Cheers to your resilience and brilliance!
Chris's work on supercoiling has been foundational for the design and execution of our synbio work! Stay tuned for updates on that!
Chris is one of the three Founders that joined in late 2019. With Adam, Nat, and now Chris defended, thus ends the Founders Era of the Galloway lab! They build a tremendous foundation which gave us the ability to run very fast and far in the last year, more on that soon. Excelsior!
Mike Gropp retweeted
Game-changers stop time. They are timeless.
Congratulations @DjokerNole for having in your hands a so deserved first ever Globe Sports Award.