@MiloFasken

Associate Scientist, Biology Dept, Emory University | #RNA fan | #Molecular #Biologist | #Yeast #Geneticist | #Runner | Opinions are my own.🧬🔬🏴󠁧󠁢󠁥󠁮󠁧󠁿

 Atlanta, Georgia
scholar.google.com/citations?user=TFXjsV8AAAAJ&hl=en&oi=ao
Joined July 2008
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117Media
In-cell structures visualize human pre-ribosome assembly in the nucleolus | Science science.org/doi/10.1126/scie…

In-cell structures visualize human pre-ribosome assembly in the nucleolus

In eukaryotes, ribosome biogenesis initiates within the nucleolus, a hallmark multilayered compartment of the nucleus. Structures of pre-ribosomes have been characterized ex situ, but their assembly...

science.org
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Nice work! 😊
Hauke Hillen@hauke_hillenSep 13
Happy to share our new preprint on the structure of the human mitochondrial RNA degradosome, a central player in organellar RNA metabolism! Work led by graduate student @paulafprado in our lab. biorxiv.org/content/10.64898… 🧵 1/9
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Escaping our own biases: AI, scientific reasoning, and discovery in molecular biology: Molecular Cell cell.com/molecular-cell/full…
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Generative design of bacteriophages with genome language models | Science science.org/doi/10.1126/scie…

Generative design of bacteriophages with genome language models

Many important biological functions arise not from single genes but from complex interactions encoded by entire genomes. We report the first generative design of complete bacteriophage genomes using...

science.org
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Milo B. Fasken, Ph.D. (he/him) retweeted
Yongsheng Shi@YongshengShiJul 16
What a cool paper! A spliceosome-independent eukaryote generated by complete intron removal: Cell cell.com/cell/fulltext/S0092…

A spliceosome-independent eukaryote generated by complete intron removal

Elimination of all spliceosomal introns reveals a spliceosome-independent eukaryote.

cell.com
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Molecular Cell@MolecularCellJul 9
Online Now: A conserved mechanism of membrane fusion in nuclear pore complex assembly dlvr.it/TTR7Z2
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Shiv Grewal@grewalshJul 8
Introns have a hidden regulatory role! 🧬🎉 Delighted to share our latest paper showing that inefficiently spliced introns and spliceosomal proteins direct RNA methylation, engaging RNAi to silence retrotransposons and regulate gene expression nature.com/articles/s41467-0…
🤖 Made with AI
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Congrats, England! 🏴󠁧󠁢󠁥󠁮󠁧󠁿😊
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Nice work! #RNAExosome #RNA link.springer.com/article/10…

Cellular assembly and functional resilience of the mammalian RNA exosome

The EMBO Journal - Most eukaryotic proteins assemble into multisubunit complexes that coordinate essential cellular functions, yet the principles governing their assembly and proteostatic control...

link.springer.com
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#RNase? 😊#RNA
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Great 1st Day at #RNADecay26 Cheers to organizers: Elena Conti Hannah Mischo Allen Buskirk Gene-Wei Li Great talks from Lori Passmore, Aaron Goldstrohm, Anita Corbett, Sutapa Chakrabarti, Ambro van Hoof, and Chris Lima, amongst others. 😊
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Time for some #RNA decay! 😊🇩🇪 rnadecay.org

RNA Decay 2026

It is our great pleasure to invite you to the 2026 Mechanisms of RNA Decay meeting. Building on a long and enriching tradition, formerly as a FASEB conference, our goal is to bring together an...

rnadecay.org
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Milo B. Fasken, Ph.D. (he/him) retweeted
nature
@NatureJun 19
Nature research paper: Molecular basis of polyadenylated RNA fate determination in the nucleus go.nature.com/4vqgvYI
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Matthew Taliaferro@JMTaliJun 11
New paper! How do RNAs "know" where to go inside a cell? We dug into the sequence elements that route RNAs to the right place. It turns out that, in mammals, they're surprisingly massive (>200 nt), multipartite, and wonderfully complicated. 🧵
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Matthias Mann Lab@labs_mannJun 11
Interactome mapping has been stuck at a few hundred baits over months. HIP-MS changes the regime: ~10,000 pulldowns/week at 500 samples/day, fully automated. A new era for interactomics — and a precursor to high-throughput proteomics writ large. doi.org/10.64898/2026.06.03.…
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Christine Mayr@Mayr_ChristineJun 8
Finally out in @Cellcellpress! Proteins with long intrinsically disordered regions (IDRs) are prone to misfolding during protein synthesis. This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones. cell.com/cell/fulltext/S0092…
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RNA 2026 was a blast! 😊 Congrats to organizers - Julie Claycomb, Eric Lécuyer, Anita Corbett, Rotem Karni,, Tsutomu (Tom) Suzuki, and Mihaela Zavolan! Congrats to Kristian Baker, Fátima Gebauer, and The RNA Society! Great to meet people and see inspiring #RNA science! #RNA26
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Come chat about RNA exosome assembly! Poster 429! #RNA26
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Matthias Mann Lab@labs_mannMay 28
1/5 Cell identity is written in the proteome, not in the DNA, and not always in the RNA. Out on bioRxiv today: The first cell type-resolved, MS-based proteomic atlas of the human body. biorxiv.org/content/10.64898…

A cell type-resolved proteomic atlas of the human body

Proteins define what cells do, yet their systematic quantification across human cell types has remained out of reach. Using Deep Visual Proteomics on tissue from a healthy female donor, we built an...

biorxiv.org
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Congrats, David Tollervey! 2025 RNA Society Lifetime Achievement in Science Award Winner: Dr. David Tollervey Wonderful talk on rRNA processing, the RNA exosome, stress, budding yeast, and…..the “Unknome” #RNA26
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