@Moazed_Lab

We're the Moazed lab @ HMS/HHMI. Posts managed by current lab members and Dr. Danesh Moazed.

 Boston, MA
moazed.hms.harvard.edu/
Joined June 2021
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  • Following491
  • Followers807
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All 268 AlphaFold predictions associated with our study are publicly available on #ModelArchive: modelarchive.org/doi/10.5452…. These predictions range from unbiased screening (histones or FACT subunits against core replisome subunits) to hypothesis-driven subcomplex predictions.
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Happy to share with the world that the main body of my PhD thesis (and my rotation project) on the mechanism for replisome-mediated parental histone inheritance is published in @CellCellPress today🥰! cell.com/cell/fulltext/S0092…
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TASOR loss not only disrupts H3K9me3 at L1s but increases the half-life of L1 RNA, indicating that increased L1 RNA upon TASOR loss may be partially attributed to decreased degradation, akin to the RITS complex @Moazed_Lab . Complementing findings by @Margottin11 @torbenheick
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Congratulations and farewell to @dadmehr_y as he embarks on an exciting journey towards an M.D. at UCLA! We wish you all the success and fulfillment as you pursue your dreams in medicine.
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Congratulations to Dr. Wade Harper, Dr. Spyros Artavanis-Tsakonas and Dr. Danesh Moazed for their election to the National Academy of Sciences. This is a well deserved recognition for their research excellence and contributions to science. @HarvardCellBio
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Excited to share our recent work on the establishment and epigenetic inheritance of mammalian heterochromatin and the role of DHX9 R-loop resolvase in safeguarding heterochromatin stability. #EpigeneticInheritance, #Heterochromatin, #Rloops #GeneSilencing. biorxiv.org/content/10.1101/…

Requirements for establishment and epigenetic stability of mammalian heterochromatin

Heterochromatic domains of DNA account for a large fraction of mammalian genomes and play critical roles in silencing transposons and genes, but the mechanisms that establish and maintain these...

biorxiv.org
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We are very happy to share our recent work on the requirements for establishment and epigenetic stability of mammalian heterochromatin. biorxiv.org/content/10.1101/… @antatarakis @sainiharleen @DaneshMoazed #epigenetics #H3K9me #heterochromatin

Requirements for establishment and epigenetic stability of mammalian heterochromatin

Heterochromatic domains of DNA account for a large fraction of mammalian genomes and play critical roles in silencing transposons and genes, but the mechanisms that establish and maintain these...

biorxiv.org
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We are very happy to share our pre-print on the Three Rules for Epigenetic Inheritance of Human Polycomb Silencing! What are these three rules? Read more to find out…. biorxiv.org/content/10.1101/… #epigenetics #polycomb #heterochromatin

Three rules for epigenetic inheritance of human Polycomb silencing

Heritable expression of developmental genes is mediated by autoregulating transcription factor networks (TFNs) and Polycomb repressive chromatin silencing complexes (PRCs). Whether the mammalian...

biorxiv.org
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Catching up with the Moazed Lab! We have great news to share with you all! We are happy to introduce the newest members of the Moazed lab: Wenzhi Feng (Sr. Scientist), Redi Metali (Grad Student) and Yizhe Zhang (Post-Doc). We are happy to have you!
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Congratulations to Harleen Saini (Post-Doc) for being awarded the Helen Hay Whitney Foundation Fellowship. Well deserved! Congratulations to Tiasha Shafiq (Grad Student) for successfully defending her thesis! We wish you the best in your future endeavors!
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Congratulations to Haining Zhou for starting his own lab at the Institute of Biophysics of the Chinese Academy of Sciences. We are looking forward to your lab’s discoveries!
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Opening for a new lab manager and senior scientist in the Moazed lab! Great opportunity to join our heterochromatin/epigenetics group. Apply here for lab manager: bit.ly/3qnG5OM Apply here for senior scientist: bit.ly/31UNv2S
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We are thrilled to see the very talented @dorkarole as one of the @DamonRunyon fellows this year! Congratulations, Karole!! From all of us in the Moazed lab!
Damon Runyon Cancer Research Foundation@DamonRunyon10 Aug 2021
Delighted to announce our newest class of Damon Runyon Fellows! We're honored to award seventeen remarkable postdoctoral scientists with independent funding to kickstart their research careers: bit.ly/3yBfHmr
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Would you like to maintain your knowledge of what's new in epigenetics? Then check out our most recent paper on 'A Composite DNA Element that Functions as a Maintainer Required for Epigenetic Inheritance of Heterochromatin' cell.com/molecular-cell/full…

A composite DNA element that functions as a maintainer required for epigenetic inheritance of...

Wang et al. reveal the mechanism of DNA sequence-dependent epigenetic inheritance by showing that a 130-bp composite DNA element with binding sites for three site-specific DNA binding factors acts as...

cell.com
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Welcome to the lab @R_SotomayorMena ! We are all super excited to have you on board
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Replying to @Moazed_Lab
Welcome, neighbors! Great to have you on Twitter #HMS
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Hey #sciencetwitter ... the Moazed lab is here! Follow us for all things chromatin #AcademicTwitter
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