∀ugust retweeted
Small molecule drug of the day: Talazoparib (-parib: PARP inhibitors) The privileged scaffold is a Tricyclic Pyridophthalazinone Core (1) This rigid core mimics nicotinamide and allows the molecule to effectively fit into and block the catalytic domain of PARP enzymes -1
Small molecule drug of the day: Talazoparib (-parib: PARP inhibitors) FDA approves #talazoparib with enzalutamide for metastatic androgen pathway modulation-naïve or -sensitive (mAPMN/S) prostate cancer with HRR gene mutations. xitter.cf/phsiao4/status/2114803… part 1
I had a wonderful conference with several bioengineers and computational biologists tonight. We discussed weighted directed graphs with respect to gene regulatory networks among other things.
I’ve been on such a roll lately! I just got accepted into another research position, where I’ll be working on graph-theoretic methods and such in bioengineering.
Apparently, one of the immunology labs here is working with a live virus that’s deadlier than SARS-CoV-2.
There’s something almost unsettling about the fact that your body possesses an elaborate molecular system involved in distinguishing self from potentially dangerous alterations of self, and that the entire process emerges from protein structures obeying ordinary laws of physics.
∀ugust retweeted
Aging microenvironment induces CD8+ T cell exhaustion by suppressing hepatic β-hydroxybutyrylate synthesis dlvr.it/TVrhd2

















