@Monobactam

Townsend Lab (@CATLab20) Postdoc. Department of Chemistry. Johns Hopkins University. Better living through chemical biology.

Joined January 2020
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Really excited about #MyFirstChemSci! We take the monobactam biosynthetic story to the next level and explore the innate substrate tolerance of this #NRPS to generate new compounds by mutasynthesis. A wonderful team effort! pubs.rsc.org/en/content/arti…

Synthesis of functionalized 2,3-diaminopropionates and their potential for directed monobactam...

The N-sulfonated monobactams harbor considerable potential to combat emerging bacterial infections that are problematic to treat due to their metallo-β-lac

pubs.rsc.org
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Very happy to see this now fully online! Amazing work by Dr. Lukas Kahlert to reimagine a well validated assay for a new purpose, with the serendipitous discovery of an unexpected mechanism as well!
ChemBioChem@ChemBioChem28 Jan 2023
Colorimetric Determination of Adenylation Domain Activity in Nonribosomal Peptide Synthetases by Using Chrome Azurol S (Townsend) @monobactam @CATLab20 @JohnsHopkins #openaccess onlinelibrary.wiley.com/doi/…
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Very proud to announce that I am #PhDone! Grateful to so many people who were part of my journey and made this day so special. To my advisor @CATLab20 thank you for all of your support, mentorship, and the opportunity to grow into the scientist I am today.
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On the road to Proctor! Excited for a week of #NaturalProducts #GRS #GRC
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What a way to start a week! Just accepted @rsc_chembio. From my midnight eureka moment to make these probes all the way to this final chapter in the TokK/ThnK story! Huge thanks to @ericasinner and @CATLab20 for a great team effort and a beautiful result! pubs.rsc.org/en/Content/Arti…

Stereochemical course of cobalamin-dependent radical SAM methylation by TokK and ThnK†

Complex carbapenems are important clinical antibiotics for difficult-to-treat infections. An essential step in the biosyntheses of these natural products i

pubs.rsc.org
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To hear more about our journey to finally solving this stereochemical ambiguity in complex carbapenem biosynthesis, catch me at this summers' Natural Products and Bioactive Compounds #GRC
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Michael Lichstrahl retweeted
DC Spurs@DCSpurs30 Mar 2022
🚨 GIVEAWAY! 🚨 What’s all this talk about cherry blossom jerseys? We found some of our limited edition DC Spurs kits while doing some spring cleaning and are giving them away! To enter: follow us here @DCSpurs and RT this post. Good luck! 🌸 #COYS
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Of all the things that have been hard to source in these last two years, I never expected the most abundant element in the universe to be one of them. @airgas is citing a Force Majeure on Hydrogen and can't supply it. Anybody on #chemtwitter know what's going on?
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Willing my E. coli to reach OD before a meeting this afternoon. Bacteria respond well to positive reinforcement
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For the vast majority of my life, it was a truly miserable experience being a DC sports fan. And tonight just reminds me that it can always be worse. Poor Buffalo...
Don't think I've ever been more entertained watching the NFL. What a weekend.
Saturdays really are the perfect time to catch up on compound characterization. All the time in the world to let those 13C NMRs run...
The new @thewombats album was totally worth the wait! Love this evolution in their sound. People Don't Change People, Time Does is incredible. #FYNTW
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So long Colorado, it's been an adventure!
This Colorado place is kinda cool I guess.
My girlfriends grandmother owns a horse and I will not be convinced otherwise. #Berniedoodle #horsedog
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Few things are more Baltimore quirky than the Miracle on 34th St!
Happy Chanukah!
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Ran a Jones' oxidation for the first time today. Usually I try to avoid any and all chromium, but I have to admit this is a great reaction. Even still, are there more eco- and safety friendly alternatives to go from -OH to -COOH? @RealTimeChem #Chemtwitter
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The Townsend lab is feeling the Halloween vibe!
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